Protein Alignment PDZ-GEF and BUD5

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: NP_009967.2
• Gene: BUD5 / 850405
• SGDID: S000000634
• Length: 642
• Species: Saccharomyces cerevisiae
• Alignment Length: 464
• Identity: 93/464 - (20%)
• Similarity: 171/464 - (36%)
• Gaps: 137/464 - (29%)

  Fly   724 RLQVNYLNAHI-------HRPS---AASTL-------TTNSTQSHLLPDYPDHVLKVYKADQTCK 771
            |:|: |||..:       .:||   :|:.|       |.|:....||..||......:|.....:
Yeast   227 RIQL-YLNKMLPHNSHKWQKPSPFDSANLLLNFRDWTTDNALLQELLLSYPTINKNKHKNHSVPR 290

  Fly   772 YVLIY-------KETTAHEVV-------------------------------MLTLQEFGIHDPS 798
            .:.|:       .|||..:::                               .|.:...|:.|..
Yeast   291 LIQIWVESYWQDSETTLKDILNFWYSHLAEYYEYQELFADIVQLFINKKRTRQLKIHYIGLTDKE 355

  Fly   799 SNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLN-DSTEPLVPDEL--ALEL---- 856
                           :::.:.|...:||          :|:.. |.|.  ..|||  |.:|
Yeast   356 ---------------IEENKPPLDYENL----------FLQYEIDKTN--ANDELCGATDLSDLL 393

  Fly   857 -------VRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEY----------VDELFELRSRYG 904
                   :.|.....|:::.:.||..|||.:.:.:..||:.|:          :|.:|.|.::..
Yeast   394 FQWKQGELLEVEAFALNVSPWSLAKTLTLLESSLYLDIETIEFTRHFKHNDTTIDSVFTLSNQLS 458

  Fly   905 VPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGA 969
            ..:|....:..:...:|                     :::|..|...||.||:.:|::.|.:.:
Yeast   459 SYVLETTLQQTHTISYW---------------------LQVALSCLYLRNLNSLASIITSLQNHS 502

  Fly   970 VSRLRQTWEKLP--SKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFI 1032
            :.||     .||  .|...||..|:.::.|:.|.:.||:.:.....:|.|.:||..::.:|:|||
Yeast   503 IERL-----SLPIDVKSDHLFQRLKVVVHPNNNYNVYRRTIKHIFHSQLPCVPFTSLLIRDITFI 562

  Fly  1033 HLGNDT-RVDG-LINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQS 1095
            ..|||| ..|| .:|.:|...:.|.|....::....|:.:.......:|...|:..::.:.....
Yeast   563 RDGNDTFTKDGNNVNMQKFNQITKIVAFAQYLQQKQYEDIHCSNTTARSLLGAMIKVHTLYNDNK 627

  Fly  1096 NAAAGTVIA 1104
            :.|....||
Yeast   628 DRAYQVSIA 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237
		RA_PDZ-GEF1	759..841	CDD:340483	12/119 (10%)
		RasGEF	871..1050	CDD:459872	49/192 (26%)
BUD5	NP_009967.2	RasGEFN	230..339	CDD:214571	18/109 (17%)
		RasGEF	409..640	CDD:214539	58/254 (23%)