Protein Alignment PDZ-GEF and ralgds

DIOPT Version :9

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: XP_005167239.1
• Gene: ralgds / 799483
• ZFINID: ZDB-GENE-081105-110
• Length: 837
• Species: Danio rerio
• Alignment Length: 677
• Identity: 149/677 - (22%)
• Similarity: 237/677 - (35%)
• Gaps: 229/677 - (33%)

  Fly   739 AASTLTTNSTQSH--------LLPDYPDHVLKVYKADQTCK------------------------ 771
            |..|:|....|.|        .|....|..|.:|   :|||
Zfish    79 AIYTITLRKVQLHQTASKGQRWLGVETDSALSLY---ETCKGRTIKAGTLEKLVEYMVSAFKGKD 140

  Fly   772 --YVLIYKET-----TAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQR------------ 817
              ||.|:..|     |..:|:.|.|..:. ..|:|..:  :||..|...:|..
Zfish   141 YTYVTIFLCTYRAFATTKQVLDLLLNRYA-KLPASGKT--KVSAEDHTELKNTVSSILGAWLDQY 202

  Fly   818 -----RLPDQ--LQNLAERISFAARYYLKLNDSTEPL---------------------------- 847
                 ..||.  ||:|..        ||:||.|...|
Zfish   203 SEDFWSPPDHECLQSLIS--------YLQLNFSGSDLERRALNLLEHFQHRQQCEVEIEGDLCSC 259

  Fly   848 ---VPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPML- 908
               .|:|.:|| ...|..||:..:...:|.|||:.|...|:::.....:..::..|.:.|...|
Zfish   260 PFATPEESSLE-DEFSPSHFMSFSPSIVAEQLTVMDAELFKRVVPYHCLGGIWSQRDKKGKEHLA 323

  Fly   909 -------SKFAELVNREMFWVVSEICAEHNIVR---RMKIVKQFIKIARHCKECRNFNSMFAIVS 963
                   |:|..:.|     .|...|.::..:|   |.|.::.:|::||.|:..::|:|:.||:|
Zfish   324 PTIRATVSQFNSVTN-----CVIATCLDNRSLRPFQRAKRIEHWIEVARKCRILKSFSSLKAILS 383

  Fly   964 GLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPI---------- 1018
            .|...|:.|||:.|:.:..:..|.|.:|.::.....|.|..|:|:..|..::..|
Zfish   384 ALQSNAIHRLRRAWDDVSRESYRTFQELSEIFSDDNNYSLSRELLIKEGTSKSAIVEINHKGAQR 448

  Fly  1019 --------------IPFYPIVKKDLTFIHLGNDTRVD-GLINFEKLRM---LAKEVRLLTHMCSS 1065
                          ||:......||..:.......:: |||||||.|.   :..:::||...|:.
Zfish   449 RHQQQRDMGVVQGTIPYLGTFLTDLVMLDTAMKDHLEVGLINFEKRRKEFEVIAQIKLLQLTCNY 513

  Fly  1066 PYDLLSILELKGQSPSNALFSLNQM---------------SASQS---NAAAGTVIAANAGQATI 1112
             |:                ||.||.               |.|.|   ...:.::...|.|  .:
Zfish   514 -YN----------------FSRNQRFIDWFKRVEKLTETESYSMSCDIEPPSESLCKKNGG--IM 559

  Fly  1113 KRRKKS---TAAPNPKKMFEE---AQMVRRVKAYLNSLKILS--------DEDLLHKFSLECEPA 1163
            ||..:.   ::|.:..|.||:   :|.....|...:||.:.|        ||.|    ||...|.
Zfish   560 KRMSEESGYSSAASHSKSFEQPRLSQFKDCFKDGADSLSLTSAGSSGSDADESL----SLLNSPE 620

  Fly  1164 HGS--TYSGSISHGNTS----------------------HRSGGGGSISGGAGGSSGGGGGGSSS 1204
            .||  |.:.::.|.:||                      ..||.|..:..|...|:......|||
Zfish   621 SGSQRTSTPTVKHSSTSETGELPSDSSTKLWESPTPSSLEASGSGLCLESGCSSSTSSSSSSSSS 685

  Fly  1205 LNA--GDQLSIYSHTSSSSAPNSSLSL 1229
            ::|  |...:.:..:.|..:..|||||
Zfish   686 VSAFTGRTFNFHKRSVSGISDYSSLSL 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	27/133 (20%)
		RasGEF	871..1050	CDD:279011	52/214 (24%)
		Rhomboid_SP	1252..>1357	CDD:289371
ralgds	XP_005167239.1	RasGEFN	116..240	CDD:214571	26/134 (19%)
		RasGEF	278..543	CDD:238087	65/286 (23%)
		RalGDS_RA	721..806	CDD:176351

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810