DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDZ-GEF and 1700123K08Rik

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_083969.1	Gene:	1700123K08Rik / 76658	MGIID:	1923908	Length:	295	Species:	Mus musculus

Alignment Length:	240	Identity:	49/240 - (20%)
Similarity:	79/240 - (32%)	Gaps:	59/240 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 TPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELR--DRV 349
            |...:|..|::..:...|.:|||        .|..:.:.|.|..||.....|.:::.:|.  .:.
Mouse   101 TTWEVLDLLMKTYASFQPDFVED--------QQTKRAIFSFLFGWFQKFPQDFYESPDLAVLSQF 157

  Fly   350 TRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRD 414
            |..|.|.|.:...|.:| .|....||..||:                 |.|..........|.|.
Mouse   158 TEYVRLNVPSPDIDTQA-REPPSMLEDQEAI-----------------ALKLEEDPLGQDASGRQ 204

  Fly   415 EPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVG-LKRGDQIHEVNGQSLDHVTSKR 478
            |.|..|                           |.|.|:..| .|.|:....|....||....|.
Mouse   205 ETLALR---------------------------PASMAEPQGDEKPGENTELVKRAVLDPFEPKA 242

  Fly   479 ALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGS 523
            .:| |..:.|.::...::.  :..:..|::.....|...|.::|:
Mouse   243 TIE-LPPSLHQALPTSADT--YSPVDVAIDEAADEAADVSPASGT 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571	26/114 (23%)
		PDZ_signaling	404..494	CDD:238492	18/90 (20%)
		DegQ	<422..494	CDD:223343	13/72 (18%)
		PDZ_GEF_RA	757..841	CDD:176380
		RasGEF	871..1050	CDD:279011
		Rhomboid_SP	1252..>1357	CDD:289371
1700123K08Rik	NP_083969.1	REM	89..176	CDD:100121	20/83 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900