DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and Rapgef2

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_011238578.1 Gene:Rapgef2 / 76089 MGIID:2659071 Length:1657 Species:Mus musculus


Alignment Length:1720 Identity:615/1720 - (35%)
Similarity:848/1720 - (49%) Gaps:449/1720 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 INRPEL----HQKCNR------------------------GSHSSDTSSAYSGSDTMASNY-ASS 64
            :.:|.|    |.:|.:                        .|||..:.::.|||.:::..| |:.
Mouse   164 VGKPPLPRGYHTECTKSQLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATE 228

  Fly    65 LEAEEIDLSGLVESVVDS----DEEDLAESMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQG 125
            .||.::|||||.|:.|||    ||||:..:.|.|..||.|||||||||.:|:::|:|.||||...
Mouse   229 SEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQ 293

  Fly   126 LKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGD 190
            |.||.|:|::|||.||:|||||||::|||:|::||||||||||::||:||:.:.:|..|.|.||:
Mouse   294 LPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGN 358

  Fly   191 SFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIG 255
            |||:.|||||.|.:||||||.||||||||.|.||.||.:|.|:|.::.|:| |.:|||.|.|.:.
Mouse   359 SFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEE-GEIVMVKEHRELD 422

  Fly   256 GAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQN 320
            ..||                  ::||:||:||.|||...||||:|:.|||::||||||:|.|:.:
Mouse   423 RTGT------------------RKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSS 469

  Fly   321 PQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKK 385
            |.||..|||.||:        ...|||:|||||||||||||.|||.|..|..|||.||..|||:|
Mouse   470 PMEVGKKLLEWFN--------DPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREK 526

  Fly   386 LLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGS 450
            :...||||:|||||||:.|..|||:.||:.||.|.::||.|          ...||::..|:..|
Mouse   527 MGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSE----------KGFGIFVDSVDSCS 581

  Fly   451 KAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAG 515
            ||.:.||||||||.|||||:.:::...:|:|||...|||||:||:||..|||::..|...     
Mouse   582 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE----- 641

  Fly   516 SGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDC 580
                       |...:|......||.|                ||      |.|..|:.:|    
Mouse   642 -----------KRNGAPHLPKIGDIKK----------------AS------RYSIPDLAVD---- 669

  Fly   581 APPQTPPVSGSGNMASNFMQQL--LQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALA 643
                              ::|:  |:.||    |||..|       |.||      :.:|:|.|.
Mouse   670 ------------------VEQVIGLEKVN----KKSKAN-------TVGG------RNKLKKILD 699

  Fly   644 KMNL-------LNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQ 701
            |..:       .|....|.|.:||   ::...::|....:...|.|.||                
Mouse   700 KTRISILPQKPYNDIGIGQSQDDS---IVGLRQTKHIPAALPVSGTLSS---------------- 745

  Fly   702 SNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKA 766
            |||||                       |.:| ||....||          .||.||.||:|:||
Mouse   746 SNPDL-----------------------LQSH-HRILDFST----------TPDLPDQVLRVFKA 776

  Fly   767 DQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERIS 831
            ||..:|::|.|:|||.|||:..::||.:......:|||||||...|::|||||||||..||:||.
Mouse   777 DQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQ 841

  Fly   832 FAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDEL 896
            .:.|||||.|..||.|..||.|.||:|||.:..|.|:..|:|.||::::|..||.||.|||:|:|
Mouse   842 LSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDL 906

  Fly   897 FELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAI 961
            |:|:|:.....|.||.|::|:|.|||.|||..|.|.::||||:|.|||||.||:||:||||||||
Mouse   907 FKLKSKTSCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAI 971

  Fly   962 VSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVK 1026
            :|||....|:|||.||||||:||::||.|||||.||||||:|||.::|.:.| |.|:||.:|::|
Mouse   972 ISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNL-QPPVIPLFPVIK 1035

  Fly  1027 KDLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMS 1091
            |||||:|.|||::||||:|||||||:|||:|.:..|.|...|...:...: :....:|.||:|.|
Mouse  1036 KDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTR-KKKWRSLGSLSQGS 1099

  Fly  1092 ASQSNAAAGTV--IAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLH 1154
            |:      .||  :|...|.   |:|.:.::..|.||::|:|||.|:||.||::|::..||:.|.
Mouse  1100 AN------ATVLDVAQTGGH---KKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQ 1155

  Fly  1155 KFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISGGAGGSSGGGGGGSSSL--NAGDQLSIYSHT 1217
            ..||:||||                                      :|:|  |.||:..:.|.|
Mouse  1156 TLSLQCEPA--------------------------------------TSTLPKNPGDKKPVKSET 1182

  Fly  1218 SSSSAPNSSLSLRKRHPSSP--------TLSTTSSTSSTSDHQRRQM--HNNGPKFGTASPQAVK 1272
             |..||.:. ..:|..|..|        .:|......:.|.:..|:.  ..:.|.||..||||:|
Mouse  1183 -SPVAPRAG-PQQKVQPQQPLAQPQPPHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALK 1245

  Fly  1273 KMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATS-----AVAN 1332
            |:|||||...:.       ||.......|     .:|:...|:|.     |||.:|     |:|.
Mouse  1246 KILSLSEEGSLE-------RHRKQAEDTI-----SNASSQLSSPP-----TSPQSSPRKGYALAL 1293

  Fly  1333 VQCTPSPSPCSHRRLASGGNIIPSR-------AIHE------------------RSHSDTPAPPP 1372
            .....:.|...|..::|..:|:.:.       ::|:                  |....|...|.
Mouse  1294 SGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPD 1358

  Fly  1373 PLPSVDLSLES-SSVTTFRDLPLRKSVTS------------------------GSISSCDSG--- 1409
                 ..||.| :.|:..|.|....:|.|                        ||.:||.||   
Mouse  1359 -----QYSLGSYAPVSESRGLYAAATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHD 1418

  Fly  1410 ----YVHQQQ-------HYHLQY---------------------------QQQQQQNSSQHEPSP 1436
                ..||:.       |.|..|                           :|.|.:.|.:...|.
Mouse  1419 NIQTIQHQRSWETLPFGHTHFDYSGDAASIWASGGHMDQMMFSDHSTKYNRQNQSRESLEQAQSR 1483

  Fly  1437 PVYTAADCRLLQQISNNAVT------RNLNSPCQSTNTPPST-----PTPPPNQ----PTATIQL 1486
            ..:.::.....:....:..|      :::::..:|::..|.|     |.|.|..    |:.|..|
Mouse  1484 ASWASSTGYWGEDSEGDTGTIKRRGGKDVSAEAESSSMVPVTTEEAKPVPMPAHIAVTPSTTKGL 1548

  Fly  1487 SA---------PPTAAAYM------------H-ARS--QHQQLQQQQQSLAMPPPPPPPYNVPPL 1527
            .|         |||...|:            | ||.  .:....|:.:.:|.|...|.|...|| 
Mouse  1549 IARKEGRYREPPPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARPTEAPAPGQTPP- 1612

  Fly  1528 GSIYSHHQGTAGSRHLNHMHGKTTGPQERW 1557
                    ..|.||         .|.:.:|
Mouse  1613 --------AAAASR---------PGSKPQW 1625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 70/108 (65%)
RasGEFN 279..400 CDD:214571 71/120 (59%)
PDZ_signaling 404..494 CDD:238492 40/89 (45%)
DegQ <422..494 CDD:223343 31/71 (44%)
PDZ_GEF_RA 757..841 CDD:176380 46/83 (55%)
RasGEF 871..1050 CDD:279011 109/178 (61%)
Rhomboid_SP 1252..>1357 CDD:289371 31/111 (28%)
Rapgef2XP_011238578.1 CAP_ED 37..143 CDD:237999
cNMP 297..412 CDD:197516 72/115 (63%)
RasGEFN 428..541 CDD:214571 71/120 (59%)
PDZ_signaling 545..625 CDD:238492 40/89 (45%)
degP_htrA_DO <565..689 CDD:273938 58/204 (28%)
RA_PDZ-GEF1 769..851 CDD:340483 44/81 (54%)
RasGEF 874..1099 CDD:238087 125/226 (55%)
PHA03379 <1522..>1643 CDD:223066 28/122 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 239 1.000 Domainoid score I2265
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 875 1.000 Inparanoid score I406
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002053
OrthoInspector 1 1.000 - - otm43930
orthoMCL 1 0.900 - - OOG6_104221
Panther 1 1.100 - - O PTHR23113
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 1 1.000 - - X1353
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.940

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