DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDZ-GEF and Rasgef1c

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_001334391.1	Gene:	Rasgef1c / 74563	MGIID:	1921813	Length:	469	Species:	Mus musculus

Alignment Length:	327	Identity:	89/327 - (27%)
Similarity:	145/327 - (44%)	Gaps:	70/327 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   747 STQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDG 811
            ||..||    .|.|.::...|:|       ..:..|:::....|:.             .|:|.|
Mouse   132 STIGHL----TDVVGRISPCDET-------YGSRVHQLLQTLHQKL-------------ASLGQG 172

  Fly   812 GMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQL 876
                    |:.|....:.||:          .|:|  |..:..||:...:      :.|.||.||
Mouse   173 --------PESLVGADKPISY----------RTKP--PASIHRELLGVCS------DPYTLAQQL 211

  Fly   877 TLQDFANFRQIESTEYV------DELFELRSRYG--VPMLSKFAELVNREMFWVVSEICAEHNIV 933
            |..:....|.|...|:|      |.|...:.|:.  ...:..:.:..||..:.|.:|||......
Mouse   212 THVELERLRHIGPEEFVQAFVNKDPLAGTKPRFSDKTNNVEAYVKWFNRLCYLVATEICMPAKKK 276

  Fly   934 RRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPS 998
            :|.::::.||.:||.|....||||:.||:||:....||||::||.|:  |..:.| .|:..|||:
Mouse   277 QRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAKFF-ILEHQMDPT 338

  Fly   999 RNMSKYR--------QLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV-DGLINFEKLRMLAK 1054
            .|...||        :.::|....:..:|||:.::.||:.|::.|...|: :|.:||||...|||
Mouse   339 GNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAK 403

  Fly  1055 EV 1056
            :|
Mouse   404 QV 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	13/83 (16%)
		RasGEF	871..1050	CDD:279011	62/195 (32%)
		Rhomboid_SP	1252..>1357	CDD:289371
Rasgef1c	NP_001334391.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910