DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and Rasgef1a

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_001349032.1	Gene:	Rasgef1a / 70727	MGIID:	1917977	Length:	498	Species:	Mus musculus

Alignment Length:	468	Identity:	102/468 - (21%)
Similarity:	181/468 - (38%)	Gaps:	119/468 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   714 GSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQS---HLLPD---YPDHVL--------KVY 764
            |...||...|...:.:.:..         ||:.|.::   ||:|.   |||...        :|:
Mouse    33 GERGGGASSGSKDLIFQDGR---------LTSGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVF 88

  Fly   765 --------KADQTC---------------------KYVLIYKETT-------AHEVVMLTLQEFG 793
                    :..|.|                     |.|.:.||.|       ..|.||..|:..
Mouse    89 MPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFSTKIVQLLKEWTEAFPYDFQDEKVMAELKAI- 152

  Fly   794 IHDPSSNFSLCEVSV------GDGGMVKQRRLPDQLQNLAERISFAARYYL-KLNDSTEPLVPDE 851
                :...:.|:..:      .:.|.|| :.:...:|:|.  :|.|||..| :|.:.....|.|:
Mouse   153 ----AHRVTQCDEYLMQPRPSQENGTVK-KAIAQMIQSLL--LSLAARSQLQELREKLRSPVVDK 210

  Fly   852 ----LALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTE------YVDELFELRSRYGVP 906
                .|.....:.::..:..:...||.|||..:......|...:      ::|.|...|.|..:.
Mouse   211 GPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRGDMT 275

  Fly   907 ---MLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHG 968
               .|..:....|.....|.:|:|.......|.::::.||.:||.|....|||||.||:||:...
Mouse   276 KTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLS 340

  Fly   969 AVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLV--------SAELLAQHPIIPFYPIV 1025
            .|:||::||.|:.:   ..|:.|:..||||.|...||..:        :|....:..:||.:.:.
Mouse   341 PVARLKKTWSKVKT---AKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNLF 402

  Fly  1026 KKDLTFIH-LGNDTRVDGLINFEKLRMLAKEV-----------------RLLTHMCSSPY---DL 1069
            .||:.|:| :..:...:|.|||:|...:::::                 ::.:::.::|.   :.
Mouse   403 VKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLTAPIYSEEA 467

  Fly  1070 LSILELKGQSPSN 1082
            |.|...:.:.|.|
Mouse   468 LFIASFESEGPEN 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	25/134 (19%)
		RasGEF	871..1050	CDD:279011	57/196 (29%)
		Rhomboid_SP	1252..>1357	CDD:289371
Rasgef1a	NP_001349032.1	REM	57..163	CDD:100121	20/110 (18%)
Rasgef1a	NP_001349032.1	RasGEF	235..427	CDD:306970	56/194 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910