DRSC/TRiP Functional Genomics Resources

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Protein Alignment PDZ-GEF and SOS2

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_008870.2 Gene:SOS2 / 6655 HGNCID:11188 Length:1332 Species:Homo sapiens


Alignment Length:1452 Identity:270/1452 - (18%)
Similarity:449/1452 - (30%) Gaps:547/1452 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   293 QQLVEENSMTDPTYVEDFLLTHRIF-----------IQNPQEVTSKLLHWFDLEQVDAHKTQELR 346
            :|.:.|.:|....:.|.||...::|           |.:..|:|.|||...:       .|.|:.
Human   211 RQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIE-------DTVEMT 268

  Fly   347 DRVTRVVLLWVNNHFTDFEAD-----YEMM-------EFLEVFEALLERK--------------- 384
            |..:...|  ..:.|.|...:     ||.:       ||.|.|..|:.|.               
Human   269 DESSPHPL--AGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKE 331

  Fly   385 ---------------------KLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELR 428
                                 :||.||:    ||:.:...|.|          ||..|.....|:
Human   332 AVRYVLPRLMLVPVYHCWHYFELLKQLK----ACSEEQEDREC----------LNQAITALMNLQ 382

  Fly   429 GVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQI-----HEVNGQSLDHVTSKRALEILTGTTH 488
            |       :...||        |......:.||.:     |::..:   |:..|:..||      
Human   383 G-------SMDRIY--------KQYSPRRRPGDPVCPFYSHQLRSK---HLAIKKMNEI------ 423

  Fly   489 LSISVKSNLLGF--KEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTT 551
                 :.|:.|:  |:|.|                              |.|:.. :.|      
Human   424 -----QKNIDGWEGKDIGQ------------------------------CCNEFI-MEG------ 446

  Fly   552 DELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSG-NMASNFMQQLLQSVNNSSAKKSG 615
             .|:.:.|.:..|:.....: |:..:|:....:.|..|.:. .:...|:.:.:|.          
Human   447 -PLTRIGAKHERHIFLFDGL-MISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQI---------- 499

  Fly   616 GNSNSDQQDT---KGGFMTLAPKRRLQKALAKMNLLNKQN---------HGSSLNDSSDTLL--- 665
                .|::||   |..| .|..|.......|..:...|.|         :.|:|:...|::|   
Human   500 ----CDKEDTCEHKHAF-ELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKE 559

  Fly   666 -NDPKSKL------------SAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDA 717
             |:...:|            |..:........|.:|..:..||.:.:                  
Human   560 ENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVK------------------ 606

  Fly   718 GGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAH 782
                    .:..|..|::..                |::....|..|::  .||         ..
Human   607 --------LIERLTYHMYAD----------------PNFVRTFLTTYRS--FCK---------PQ 636

  Fly   783 EVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLP----------DQLQNLAERISFAARYY 837
            |::.|.::.|.|.:|       |.:..|...:::...|          :.:|.:..||....|::
Human   637 ELLSLLIERFEIPEP-------EPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHW 694

  Fly   838 -----------LKLNDSTEPLVPD----------ELALELVRES----------NVHF------- 864
                       |:|.:..|..:..          |...:::|..          |:.|       
Human   695 VEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPI 759

  Fly   865 ---------------LHLNAYELAIQLTLQDFANFRQIESTEYVDELF-----ELRSRYGVPMLS 909
                           :.|:..|:|.||||.:...:|:::.:|.|..::     |:.|    |.|.
Human   760 EWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINS----PNLL 820

  Fly   910 KFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLR 974
            |..........|....|....|...|:.::.:.|:|.:..::..|||.:..|||.:...:|.||.
Human   821 KMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLD 885

  Fly   975 QTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGND-- 1037
            .|:|.|..:.:::.::..:|...  :..||  ||..:.: ..|.:||:.|...::.....||:  
Human   886 HTFEALQERKRKILDEAVELSQD--HFKKY--LVKLKSI-NPPCVPFFGIYLTNILKTEEGNNDF 945

  Fly  1038 --TRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAG 1100
              .:...||||.|.|.:|:....:....:.||.|                               
Human   946 LKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCL------------------------------- 979

  Fly  1101 TVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDE---DLLHKFSLECEP 1162
                              ...|:.::.||.          ||.:...|::   |.|...|||.||
Human   980 ------------------RIEPDMRRFFEN----------LNPMGSASEKEFTDYLFNKSLEIEP 1016

  Fly  1163 AH---------GSTYSGSISHGNTSHRSGGGGSISGGAGGSSGGGGGGSSSLNAGD--------- 1209
            .:         .||:         |.:|.|....:|..|.:||...|..:.|....         
Human  1017 RNCKQPPRFPRKSTF---------SLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIA 1072

  Fly  1210 QLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKM 1274
            :..:.|..|:.::||:        ||:|.:|.:|..|...|........:...|........|..
Human  1073 ETELESTVSAPTSPNT--------PSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSF 1129

  Fly  1275 LSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSP 1339
            .|...|......:|.:|          |||.........::.|.|.:.:.....|:...|   .|
Human  1130 FSSCGSLHKLSEEPLIP----------PPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQ---PP 1181

  Fly  1340 SPCSHRRLASGGNIIPSRAIHERSHSDTPAPP-PPLPSVDLSLESSSVTTFRDLPLRKSVTSGSI 1403
            .|....|:.     :|:.|.....||..|.|| .|||.           |...:|||        
Human  1182 PPKVKPRVP-----VPTGAFDGPLHSPPPPPPRDPLPD-----------TPPPVPLR-------- 1222

  Fly  1404 SSCDSGYVHQQQH-----YHLQYQQQQQQNSSQHEPSPPVYTAADCRLLQQISNNAVTRNLNSPC 1463
                     ..:|     ::||             |.|..:...|...|:.||...     ||| 
Human  1223 ---------PPEHFINCPFNLQ-------------PPPLGHLHRDSDWLRDISTCP-----NSP- 1259

  Fly  1464 QSTNTPPSTPTPPPNQPTATIQLSAPPTAAAYMHARSQHQQLQQQQQSLAMPPPPPPPYNVPPLG 1528
               :||||||:  |..|.....||:                   .|.:||.||.||    |||..
Human  1260 ---STPPSTPS--PRVPRRCYVLSS-------------------SQNNLAHPPAPP----VPPRQ 1296

  Fly  1529 SIYSHHQGTAGSRHLNHMHGKT 1550
            :         .|.||..:..||
Human  1297 N---------SSPHLPKLPPKT 1309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999
RasGEFN 279..400 CDD:214571 33/165 (20%)
PDZ_signaling 404..494 CDD:238492 17/94 (18%)
DegQ <422..494 CDD:223343 12/76 (16%)
PDZ_GEF_RA 757..841 CDD:176380 17/104 (16%)
RasGEF 871..1050 CDD:279011 48/187 (26%)
Rhomboid_SP 1252..>1357 CDD:289371 17/104 (16%)
SOS2NP_008870.2 Histone 63..169 CDD:329110
RhoGEF 199..386 CDD:238091 40/204 (20%)
PH_SOS 437..543 CDD:269963 23/159 (14%)
RasGEFN 595..739 CDD:214571 27/203 (13%)
RasGEF 774..1013 CDD:238087 63/306 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1018..1061 11/51 (22%)
NupH_GANP <1023..>1142 CDD:318883 26/135 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1076..1096 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1142..1332 63/270 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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