DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and SOS1

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_005624.2 Gene:SOS1 / 6654 HGNCID:11187 Length:1333 Species:Homo sapiens


Alignment Length:1674 Identity:300/1674 - (17%)
Similarity:530/1674 - (31%) Gaps:580/1674 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 TMASNYASSLEAEEIDLSGL----------VESVVDSDEEDLAESMDSLTVRDAVRDCLEK---- 106
            |:.||..:....||:.|..|          ...|.:..::.....:|...:.|| :..:||    
Human    37 TLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA-QSAIEKRKRR 100

  Fly   107 DPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLIN 171
            :|.....|.:..||:...|.|....:         ||.:.||::.....::.          |:.
Human   101 NPLSLPVEKIHPLLKEVLGYKIDHQV---------SVYIVAVLEYISADILK----------LVG 146

  Fly   172 GAV-EIEHANGSREELQMGDSFGILPTMDK----LYHRGVMRTKCDDCQFVCITQTD-------- 223
            ..| .|.|...::::::      :....||    ::|:.|     :|...:.:|..:        
Human   147 NYVRNIRHYEITKQDIK------VAMCADKVLMDMFHQDV-----EDINILSLTDEEPSTSGEQT 200

  Fly   224 YYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASA---SLNMK-RGHV-- 282
            ||.:........|::..|...::.|.....:..:...||....:......   .|::| .||:  
Human   201 YYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIED 265

  Fly   283 ----VIRGTPERLL----QQLVEENSMTDP--TYVEDFLLT--HRIFIQNPQEVTSKLLHWFDLE 335
                ...|:|..|:    :.|.||.:. ||  :|..|.|..  |..|:....:..:.|.    |:
Human   266 TVEMTDEGSPHPLVGSCFEDLAEELAF-DPYESYARDILRPGFHDRFLSQLSKPGAALY----LQ 325

  Fly   336 QVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAK 400
            .:.....:.::..:.|::|..|          |..:.:.|:.:.|.|:.:.......|..|..|.
Human   326 SIGEGFKEAVQYVLPRLLLAPV----------YHCLHYFELLKQLEEKSEDQEDKECLKQAITAL 380

  Fly   401 ARMRS-----CTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRG 460
            ..::|     |:.:.:.|                   ....:|...|...:    |.:.:.:|:.
Human   381 LNVQSGMEKICSKSLAKR-------------------RLSESACRFYSQQM----KGKQLAIKKM 422

  Fly   461 DQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGF--KEIMQALEHGGGTAGSGSISAGS 523
            ::|                              :.|:.|:  |:|.|                  
Human   423 NEI------------------------------QKNIDGWEGKDIGQ------------------ 439

  Fly   524 GSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPV 588
                        |.|:.. :.|       .|:.|.|.:..|:.....: |:..:.:...|:.|  
Human   440 ------------CCNEFI-MEG-------TLTRVGAKHERHIFLFDGL-MICCKSNHGQPRLP-- 481

  Fly   589 SGSGNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNH 653
                                       |.||::.:..:..||     |::|              
Human   482 ---------------------------GASNAEYRLKEKFFM-----RKVQ-------------- 500

  Fly   654 GSSLNDSSDT---------LLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQS--QSNPDLT 707
               :||..||         :|.|..|.:  .|:.|:..:::.....:|   ..|:|  :...|:|
Human   501 ---INDKDDTNEYKHAFEIILKDENSVI--FSAKSAEEKNNWMAALIS---LQYRSTLERMLDVT 557

  Fly   708 SLNYDGGSDAGGNGGGRLQVNYLNAHIHR-----------------PSAASTLTTNSTQSHLL-- 753
            .|..:...          |:...:|.::|                 |.|...:....|...|:  
Human   558 MLQEEKEE----------QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIER 612

  Fly   754 --------PDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVG 809
                    |::....|..|::  .||         ..|::.|.::.|.|.:|. :......:..|
Human   613 LTYHMYADPNFVRTFLTTYRS--FCK---------PQELLSLIIERFEIPEPEPTEADRIAIENG 666

  Fly   810 DGGMVKQ--RRLPDQLQNLAERISFAARYYL------------------------------KLND 842
            |..:..:  |...:.:|.:..|:....|:::                              |..:
Human   667 DQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVE 731

  Fly   843 STEPLV--------------------PDELALELVRESNVH---FLHLNAYELAIQLTLQDFANF 884
            |...::                    |..:...:.|..::.   .|.|:..|:|.||||.:...:
Human   732 SITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLY 796

  Fly   885 RQIESTEYVDELF-----ELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIK 944
            |.::.:|.|..::     |:.|    |.|.|..........|....|....|:..|:.:|.:.|:
Human   797 RAVQPSELVGSVWTKEDKEINS----PNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIE 857

  Fly   945 IARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDP--SRNMSKYRQL 1007
            |.:..:|..|||.:..:||.:....|.||..|:|::||:.:::..:..:|.:.  .:.::|.|.:
Human   858 ILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSI 922

  Fly  1008 VSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV----DGLINFEKLRMLAKEVRLLTHMCSSPYD 1068
                   ..|.:||:.|...::.....||...:    ..||||.|.|.:|:....:....:.||.
Human   923 -------NPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYC 980

  Fly  1069 LLSILELKGQSPSNALF-SLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAP-NPKKMFEEA 1131
                  |:.:|.....| :||.|..|........:.           .|.....| |||      
Human   981 ------LRVESDIKRFFENLNPMGNSMEKEFTDYLF-----------NKSLEIEPRNPK------ 1022

  Fly  1132 QMVRRVKAYLNSLKILS-------DEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISG 1189
            .:.|..|.|...||...       ...:.|...|:.||...| || .|....|.           
Human  1023 PLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKIS-YS-RIPESETE----------- 1074

  Fly  1190 GAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTS-STSDHQR 1253
                                        |::|||||..:.....|:|...|||...| ..|||..
Human  1075 ----------------------------STASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSS 1111

  Fly  1254 RQMHNN-----------GPKFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHM 1307
            ....:|           ||:..:.|      .:||::.:...|..|           .:||....
Human  1112 PFHSSNDTVFIQVTLPHGPRSASVS------SISLTKGTDEVPVPP-----------PVPPRRRP 1159

  Fly  1308 HAAHGFSTPSPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTPAPPP 1372
            .:|...|:||.  :::....|..|    .|...|.|..       ..|..:|.:|:....|...|
Human  1160 ESAPAESSPSK--IMSKHLDSPPA----IPPRQPTSKA-------YSPRYSISDRTSISDPPESP 1211

  Fly  1373 PLPSVDLSLESSSVTTFRDLPLRKSVTSGSISSCDSGYVHQQQHYHLQYQQQQQQNSSQHEPSPP 1437
            ||                 ||.|:.|.:..:.|                      :|..|...||
Human  1212 PL-----------------LPPREPVRTPDVFS----------------------SSPLHLQPPP 1237

  Fly  1438 VYTAADCRLLQQISNNAVTRNLNSPCQSTNTPPSTPTPPPNQPTATIQLSAPP-TAAAYMHARSQ 1501
            :...:|       ..||...  |||...|..||.||:|...:.    .|.:|| |....:|    
Human  1238 LGKKSD-------HGNAFFP--NSPSPFTPPPPQTPSPHGTRR----HLPSPPLTQEVDLH---- 1285

  Fly  1502 HQQLQQQQQSLAMPPPPPPPYNVPPLGSIYSHHQGTAGSRHLNHMHGKT 1550
                     |:|.||.||              .|.|  |:|:..:..||
Human  1286 ---------SIAGPPVPP--------------RQST--SQHIPKLPPKT 1309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 16/121 (13%)
RasGEFN 279..400 CDD:214571 26/134 (19%)
PDZ_signaling 404..494 CDD:238492 8/94 (9%)
DegQ <422..494 CDD:223343 5/71 (7%)
PDZ_GEF_RA 757..841 CDD:176380 16/116 (14%)
RasGEF 871..1050 CDD:279011 48/189 (25%)
Rhomboid_SP 1252..>1357 CDD:289371 20/115 (17%)
SOS1NP_005624.2 Histone 63..169 CDD:333859 20/131 (15%)
RhoGEF 204..389 CDD:214619 35/199 (18%)
PH_SOS 439..545 CDD:269963 28/200 (14%)
RasGEFN 597..741 CDD:214571 20/154 (13%)
RasGEF 776..1015 CDD:238087 62/266 (23%)
PTZ00449 <1018..1319 CDD:185628 97/450 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1103 28/130 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1333 63/292 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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