DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDZ-GEF and Gm6408

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_001230033.1	Gene:	Gm6408 / 623198	MGIID:	3779591	Length:	320	Species:	Mus musculus

Alignment Length:	324	Identity:	62/324 - (19%)
Similarity:	108/324 - (33%)	Gaps:	103/324 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 TPERLLQQL------VEENS--------MTDPTY-----VEDFLLTHRIFI--------QNPQEV 324
            :||.::|.:      |:.|.        ...|:|     |.|.|:|...|.        :..:.:
Mouse    66 SPEYVVQMIHYIPAAVQHNDHVCIRIFLAMYPSYASTWKVLDLLMTTYAFFLPDRIKDQETKRAI 130

  Fly   325 TSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQ 389
            ...|.|||.....|.:::.:|  .|.|..:.:|.::....:.|.:..|.|.|    ||.::.:..
Mouse   131 FRFLFHWFKKFPKDFYESPDL--AVVRQFIDYVRHNVPSADEDTQARELLSV----LEEQEAIGL 189

  Fly   390 LRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQD 454
            ......|.|.:...:..    |.|.|.|..|                           |.|:.:.
Mouse   190 NPEEDFATAPEPSEQDA----SGRQETLAPR---------------------------PASETEP 223

  Fly   455 VGLKRGDQIHE-VNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGS 518
            .|.|:..:..| |.|..||....|..:| |..:.|                ||:....||.....
Mouse   224 QGDKQPREDPELVKGAVLDPSEPKATIE-LPPSLH----------------QAVPTSDGTLSPVD 271

  Fly   519 ISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNR---AHMVRLSSVDMLLDQPD 579
            ::|..             |..:|     :|...|..:.||.:.:   ::.|:|.:.|.::..|:
Mouse   272 VTADE-------------ATGVA-----ADEAADVAADVSPARQLFVSYTVQLGTPDFVIPLPE 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571	29/139 (21%)
		PDZ_signaling	404..494	CDD:238492	18/90 (20%)
		DegQ	<422..494	CDD:223343	13/72 (18%)
		PDZ_GEF_RA	757..841	CDD:176380
		RasGEF	871..1050	CDD:279011
		Rhomboid_SP	1252..>1357	CDD:289371
Gm6408	NP_001230033.1	REM	89..183	CDD:100121	21/99 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900