DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and Rapgef3

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_038935756.1 Gene:Rapgef3 / 59326 RGDID:621869 Length:1003 Species:Rattus norvegicus


Alignment Length:1122 Identity:267/1122 - (23%)
Similarity:412/1122 - (36%) Gaps:390/1122 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 EEDLAESMDSLTVR--DAVRD-CLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMV 145
            ||:|.|:|..|:.|  ||:.. .|.|.|.:|::|:::::.|....:||..:::.:|:|.|.:|::
  Rat   229 EEELVEAMALLSQRGPDALLTVALRKSPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLL 293

  Fly   146 FAVVDKAGTVVMSDGEELDSWSVLINGAVE-IEHANGSREELQMGDSFGILPTMDKLYHRGVMRT 209
            |....|||||:.|.|::..||.::..|:|. :.|..|....|..||.||.|..::.......:..
  Rat   294 FEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIIL 358

  Fly   210 KCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASAS 274
            :.::|.|:.:.:.|:.||....|..|.|.| |:|.||:|.| |:..|||.....:.|        
  Rat   359 RENNCHFLRVDKQDFNRIIKDVEAKTMRLE-EHGKVVLVLE-RTSQGAGPSRPPTPG-------- 413

  Fly   275 LNMKRGHVVIRGTPERLLQQLVE----ENSMTDP--TYVEDFLLTHRIFIQNPQEVTSKLLHWFD 333
               :..:.|:.||||::|:.|:|    ::|..||  |::.||||||.:|:...| :.:.|||.|.
  Rat   414 ---RNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPCTQ-LFAALLHHFH 474

  Fly   334 LEQVDAHKTQE---------LRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQ 389
            :|..:.....|         .|.::.|:|..||..:.....:|.....||:....|:.|...||.
  Rat   475 VEPSEPAGGSEQERSTYICNKRQQILRLVSRWVALYSPMLRSDPVATSFLQKLSDLVSRDTRLSN 539

  Fly   390 LRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKA-- 452
            |                 |.....:...:.|:..|         .||         |.|.:||  
  Rat   540 L-----------------LREQYPERRRHHRLENG---------CGN---------VSPQTKAPP 569

  Fly   453 -----------------QDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGF 500
                             ||.||       :|....|.||  :::.|     |......::..:.|
  Rat   570 HTPELVMCCMFPSVTSPQDAGL-------DVRDLLLLHV--EQSCE-----TEAPEKARNAPVWF 620

  Fly   501 KEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICAND--IAKLHGRSDSTTDELSSVSASNRA 563
            ....:.|     .:.:|:|..|.      :.|..||..|  :..||          ..|:||.|.
  Rat   621 PNHEEPL-----PSSAGAIRVGD------KVPYDICRPDHSVLTLH----------LPVTASVRE 664

  Fly   564 HMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGG 628
            .|..|:..|                                                  ..||| 
  Rat   665 VMAALAHED--------------------------------------------------HWTKG- 678

  Fly   629 FMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSG 693
                       :.|.|:|                                             |.
  Rat   679 -----------QVLVKVN---------------------------------------------SA 687

  Fly   694 GGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPD 758
            |          |:..|                          :|.|....|:......:....|.
  Rat   688 G----------DVVGL--------------------------QPDARGVATSLGLNERIFVVDPQ 716

  Fly   759 HVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQL 823
            .|                .|.|.|                                     |:||
  Rat   717 EV----------------HELTPH-------------------------------------PEQL 728

  Fly   824 QNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQD---FANFR 885
                                 .|.:.....|:||          :|.:||.|||..|   |....
  Rat   729 ---------------------GPTLGSSEMLDLV----------SAKDLAGQLTEHDWNLFNRIH 762

  Fly   886 QIESTEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCK 950
            |:|...||.....||. .....|.:|....|...:||.:|:|.......|.:::::|||:|.|.|
  Rat   763 QVELIHYVLGPQHLRD-VTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLK 826

  Fly   951 ECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQ 1015
            |.:|.||.||::.||.:.|:|||..|||:||.|.::|::.|:.|:|||.|...|| |...:|  .
  Rat   827 EQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYR-LALTKL--S 888

  Fly  1016 HPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSP 1080
            .|:|||.|::.||:||||.||.|.|:.||||||:||:|:.||:| |.|.|          ...:|
  Rat   889 PPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAVRML-HHCRS----------HSTAP 942

  Fly  1081 SNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLK 1145
            .:.|.|  ::|....::.|..:       :|...:..||.:|            ....||:..||
  Rat   943 LSPLRS--RVSHIHEDSQASRI-------STCSEQSLSTRSP------------ASTWAYVQQLK 986

  Fly  1146 ILSDEDLLHKFSLECEP 1162
            ::.::..|.:.|.|.||
  Rat   987 VIDNQRELSRLSRELEP 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 32/109 (29%)
RasGEFN 279..400 CDD:214571 39/135 (29%)
PDZ_signaling 404..494 CDD:238492 19/108 (18%)
DegQ <422..494 CDD:223343 17/90 (19%)
PDZ_GEF_RA 757..841 CDD:176380 8/83 (10%)
RasGEF 871..1050 CDD:279011 77/181 (43%)
Rhomboid_SP 1252..>1357 CDD:289371
Rapgef3XP_038935756.1 DEP_Epac 131..254 CDD:239884 10/24 (42%)
CAP_ED 278..387 CDD:237999 31/108 (29%)
RasGEF_N 418..527 CDD:395493 34/109 (31%)
RasGEF 738..1003 CDD:214539 106/310 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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