DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and RASGRF2

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_008840.1 Gene:RASGRF2 / 5924 HGNCID:9876 Length:1237 Species:Homo sapiens


Alignment Length:1366 Identity:249/1366 - (18%)
Similarity:451/1366 - (33%) Gaps:426/1366 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 PPTSIAGTG-------------VVVGSSTTINRPELHQKCN---------RGSHSSDTSSAYSGS 54
            ||.:.||.|             |:.|..   .:..|..:|.         ...|.:..:......
Human    79 PPRAGAGQGGVRDALDKQYYFTVLFGHE---GQKPLELRCEEEQDGKEWMEAIHQASYADILIER 140

  Fly    55 DTMASNY---ASSLEAEEIDLSGLVESVVDSDEEDLAESMDSLTVRDAVRDCLEK-DPAERSEED 115
            :.:...|   ...:|.|:|..:.|...:.|.|.|  .|.:.|..:  |:....|: .|.:.::||
Human   141 EVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTE--IERLKSEII--ALNKTKERMRPYQSNQED 201

  Fly   116 -------VEVLLEFTQGLKAFTNITLAVRRALCS----------VMVFAVVDKAGTVVMSDGEEL 163
                   ::.:..|.:|..........|:..:||          .:||       |:|.::.|.:
Human   202 EDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVF-------TMVEAESEYV 259

  Fly   164 DSWSVLINGAVEIEH--ANGSREELQMGDSFGI------LPTMDKLYHRGVMRTKCDDCQFVCIT 220
            ....:|:||.:....  |:..:..:...|...|      :..:.:::|:|:   |.....:..:.
Human   260 HQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGL---KARIANWPTLI 321

  Fly   221 QTDYYRI----QHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGH 281
            ..|.:.|    .:..:|..|.|:    :.:.|.                       |:....|..
Human   322 LADLFDILLPMLNIYQEFVRNHQ----YSLQVL-----------------------ANCKQNRDF 359

  Fly   282 VVIRGTPERLLQQLVEENSMTDPTYVEDFL------------LTHRIFIQNPQE-VTSKLLHWF- 332
                   ::||:| .|.|...:...:|.||            ..|.:....|.| |..|.|.:. 
Human   360 -------DKLLKQ-YEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAK 416

  Fly   333 ----DLEQV---DAHKTQELRDR--VTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLS 388
                :|.:|   :...|:.:|..  :.|:::...:......:........::|  ..:||.| ||
Human   417 SKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQV--PSVERGK-LS 478

  Fly   389 QLRLLHIACAAKARMRSCTL--------TRSSR--------------------DEP--------- 416
            ::||..:: ..|...|.|.|        ||||.                    :||         
Human   479 KVRLGSLS-LKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKG 542

  Fly   417 -------LNFRIV----GGYELRGVAIATGNAAVGIYISHV-----------------EPGSKA- 452
                   |:|:||    .......|.:|........::|.:                 |..||. 
Human   543 SGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVT 607

  Fly   453 ------QDVGLKRGD-------QIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIM 504
                  .|..|.:.|       .::......:.:.:.:|.||.||....|||...:..|....|.
Human   608 VPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIF 672

  Fly   505 QALEHGGGTAGSGSISAGSGS------FKSV-----------------------RSPRRIC---- 536
            .          :.::..|..|      |.|:                       :|| |:|    
Human   673 T----------TAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSP-RLCRKFS 726

  Fly   537 -------ANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTP---PVSGS 591
                   :...:.:..|..|.|..|:|          ::.::|:..........|:|   |...:
Human   727 SPPPLAVSRTSSPVRARKLSLTSPLNS----------KIGALDLTTSSSPTTTTQSPAASPPPHT 781

  Fly   592 GNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSS 656
            |.:..:..:.|      ||.::|.|....:..:.:....... ||.:|||:              
Human   782 GQIPLDLSRGL------SSPEQSPGTVEENVDNPRVDLCNKL-KRSIQKAV-------------- 825

  Fly   657 LNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNG 721
                   |.:.|..:....||.::.| :.::.|         :|.|.|........||..|.   
Human   826 -------LESAPADRAGVESSPAADT-TELSPC---------RSPSTPRHLRYRQPGGQTAD--- 870

  Fly   722 GGRLQVNYLNAHIH-RPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEV- 784
                     |||.. .|::|..:.|.:......|.:.:       .::||....|.:.|..:.| 
Human   871 ---------NAHCSVSPASAFAIATAAAGHGSPPGFNN-------TERTCDKEFIIRRTATNRVL 919

  Fly   785 ------VMLTLQEFGIHD--PSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAAR--YYLK 839
                  |....|:|.:::  ..:..:|.|..:.|..::.|.|  ....|:...:|...:  .:||
Human   920 NVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQER--KAAANILRALSQDDQDDIHLK 982

  Fly   840 LNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDE-LFELRSRY 903
            |.|..:  :.|.:..|.       |..|:|.|||.|:||.|...||.|...|::.: ..:|....
Human   983 LEDIIQ--MTDCMKAEC-------FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNE 1038

  Fly   904 GVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHG 968
            ..|.:.|.::..|.....|.|:|....::..|...:::::.:|..|:...|:|.:..|.|.|...
Human  1039 RTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRS 1103

  Fly   969 AVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIH 1033
            |:.||::||.|:..:.:.|.:.||..:.........|:.:..   ...|.:|:..:...||.||.
Human  1104 AIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKN---CNPPAVPYLGMYLTDLAFIE 1165

  Fly  1034 LG--NDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSN 1096
            .|  |.|. :||:||.|:||::..:|.:.....:.|.:       ...|                
Human  1166 EGTPNFTE-EGLVNFSKMRMISHIIREIRQFQQTSYRI-------DHQP---------------- 1206

  Fly  1097 AAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECE 1161
                                                   :|..||....::.|||.|::.||:.|
Human  1207 ---------------------------------------KVAQYLLDKDLIIDEDTLYELSLKIE 1232

  Fly  1162 P 1162
            |
Human  1233 P 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 20/130 (15%)
RasGEFN 279..400 CDD:214571 28/143 (20%)
PDZ_signaling 404..494 CDD:238492 30/168 (18%)
DegQ <422..494 CDD:223343 18/106 (17%)
PDZ_GEF_RA 757..841 CDD:176380 17/94 (18%)
RasGEF 871..1050 CDD:279011 50/181 (28%)
Rhomboid_SP 1252..>1357 CDD:289371
RASGRF2NP_008840.1 PH_RasGRF1_2 19..158 CDD:270081 12/81 (15%)
RhoGEF 247..428 CDD:214619 38/225 (17%)
PH 480..588 CDD:214574 19/108 (18%)
RasGEF_N 638..>686 CDD:306971 12/57 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..809 19/115 (17%)
Regulates proteasomal degradation. /evidence=ECO:0000250 744..752 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..873 12/65 (18%)
RasGEFN <901..972 CDD:214571 14/72 (19%)
RasGEF 998..1234 CDD:214539 69/302 (23%)
Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250 1099..1128 9/28 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.