Sequence 1: | NP_609012.2 | Gene: | PDZ-GEF / 33881 | FlyBaseID: | FBgn0265778 | Length: | 1573 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_008840.1 | Gene: | RASGRF2 / 5924 | HGNCID: | 9876 | Length: | 1237 | Species: | Homo sapiens |
Alignment Length: | 1366 | Identity: | 249/1366 - (18%) |
---|---|---|---|
Similarity: | 451/1366 - (33%) | Gaps: | 426/1366 - (31%) |
- Green bases have known domain annotations that are detailed below.
Fly 12 PPTSIAGTG-------------VVVGSSTTINRPELHQKCN---------RGSHSSDTSSAYSGS 54
Fly 55 DTMASNY---ASSLEAEEIDLSGLVESVVDSDEEDLAESMDSLTVRDAVRDCLEK-DPAERSEED 115
Fly 116 -------VEVLLEFTQGLKAFTNITLAVRRALCS----------VMVFAVVDKAGTVVMSDGEEL 163
Fly 164 DSWSVLINGAVEIEH--ANGSREELQMGDSFGI------LPTMDKLYHRGVMRTKCDDCQFVCIT 220
Fly 221 QTDYYRI----QHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGH 281
Fly 282 VVIRGTPERLLQQLVEENSMTDPTYVEDFL------------LTHRIFIQNPQE-VTSKLLHWF- 332
Fly 333 ----DLEQV---DAHKTQELRDR--VTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLS 388
Fly 389 QLRLLHIACAAKARMRSCTL--------TRSSR--------------------DEP--------- 416
Fly 417 -------LNFRIV----GGYELRGVAIATGNAAVGIYISHV-----------------EPGSKA- 452
Fly 453 ------QDVGLKRGD-------QIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIM 504
Fly 505 QALEHGGGTAGSGSISAGSGS------FKSV-----------------------RSPRRIC---- 536
Fly 537 -------ANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTP---PVSGS 591
Fly 592 GNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSS 656
Fly 657 LNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNG 721
Fly 722 GGRLQVNYLNAHIH-RPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEV- 784
Fly 785 ------VMLTLQEFGIHD--PSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAAR--YYLK 839
Fly 840 LNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDE-LFELRSRY 903
Fly 904 GVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHG 968
Fly 969 AVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIH 1033
Fly 1034 LG--NDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSN 1096
Fly 1097 AAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECE 1161
Fly 1162 P 1162 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
PDZ-GEF | NP_609012.2 | CAP_ED | 128..237 | CDD:237999 | 20/130 (15%) |
RasGEFN | 279..400 | CDD:214571 | 28/143 (20%) | ||
PDZ_signaling | 404..494 | CDD:238492 | 30/168 (18%) | ||
DegQ | <422..494 | CDD:223343 | 18/106 (17%) | ||
PDZ_GEF_RA | 757..841 | CDD:176380 | 17/94 (18%) | ||
RasGEF | 871..1050 | CDD:279011 | 50/181 (28%) | ||
Rhomboid_SP | 1252..>1357 | CDD:289371 | |||
RASGRF2 | NP_008840.1 | PH_RasGRF1_2 | 19..158 | CDD:270081 | 12/81 (15%) |
RhoGEF | 247..428 | CDD:214619 | 38/225 (17%) | ||
PH | 480..588 | CDD:214574 | 19/108 (18%) | ||
RasGEF_N | 638..>686 | CDD:306971 | 12/57 (21%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 710..809 | 19/115 (17%) | |||
Regulates proteasomal degradation. /evidence=ECO:0000250 | 744..752 | 2/7 (29%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 829..873 | 12/65 (18%) | |||
RasGEFN | <901..972 | CDD:214571 | 14/72 (19%) | ||
RasGEF | 998..1234 | CDD:214539 | 69/302 (23%) | ||
Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250 | 1099..1128 | 9/28 (32%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2063 |
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.940 |