DRSC/TRiP Functional Genomics Resources

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Protein Alignment PDZ-GEF and RASGRF2

DIOPT Version :10

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_008840.1 Gene:RASGRF2 / 5924 HGNCID:9876 Length:1237 Species:Homo sapiens


Alignment Length:1366 Identity:249/1366 - (18%)
Similarity:451/1366 - (33%) Gaps:426/1366 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 PPTSIAGTG-------------VVVGSSTTINRPELHQKCN---------RGSHSSDTSSAYSGS 54
            ||.:.||.|             |:.|..   .:..|..:|.         ...|.:..:......
Human    79 PPRAGAGQGGVRDALDKQYYFTVLFGHE---GQKPLELRCEEEQDGKEWMEAIHQASYADILIER 140

  Fly    55 DTMASNY---ASSLEAEEIDLSGLVESVVDSDEEDLAESMDSLTVRDAVRDCLEK-DPAERSEED 115
            :.:...|   ...:|.|:|..:.|...:.|.|.|  .|.:.|..:  |:....|: .|.:.::||
Human   141 EVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTE--IERLKSEII--ALNKTKERMRPYQSNQED 201

  Fly   116 -------VEVLLEFTQGLKAFTNITLAVRRALCS----------VMVFAVVDKAGTVVMSDGEEL 163
                   ::.:..|.:|..........|:..:||          .:||       |:|.::.|.:
Human   202 EDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVF-------TMVEAESEYV 259

  Fly   164 DSWSVLINGAVEIEH--ANGSREELQMGDSFGI------LPTMDKLYHRGVMRTKCDDCQFVCIT 220
            ....:|:||.:....  |:..:..:...|...|      :..:.:::|:|:   |.....:..:.
Human   260 HQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGL---KARIANWPTLI 321

  Fly   221 QTDYYRI----QHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGH 281
            ..|.:.|    .:..:|..|.|:    :.:.|.                       |:....|..
Human   322 LADLFDILLPMLNIYQEFVRNHQ----YSLQVL-----------------------ANCKQNRDF 359

  Fly   282 VVIRGTPERLLQQLVEENSMTDPTYVEDFL------------LTHRIFIQNPQE-VTSKLLHWF- 332
                   ::||:| .|.|...:...:|.||            ..|.:....|.| |..|.|.:. 
Human   360 -------DKLLKQ-YEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAK 416

  Fly   333 ----DLEQV---DAHKTQELRDR--VTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLS 388
                :|.:|   :...|:.:|..  :.|:::...:......:........::|  ..:||.| ||
Human   417 SKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQV--PSVERGK-LS 478

  Fly   389 QLRLLHIACAAKARMRSCTL--------TRSSR--------------------DEP--------- 416
            ::||..:: ..|...|.|.|        ||||.                    :||         
Human   479 KVRLGSLS-LKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKG 542

  Fly   417 -------LNFRIV----GGYELRGVAIATGNAAVGIYISHV-----------------EPGSKA- 452
                   |:|:||    .......|.:|........::|.:                 |..||. 
Human   543 SGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVT 607

  Fly   453 ------QDVGLKRGD-------QIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIM 504
                  .|..|.:.|       .::......:.:.:.:|.||.||....|||...:..|....|.
Human   608 VPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIF 672

  Fly   505 QALEHGGGTAGSGSISAGSGS------FKSV-----------------------RSPRRIC---- 536
            .          :.::..|..|      |.|:                       :|| |:|    
Human   673 T----------TAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSP-RLCRKFS 726

  Fly   537 -------ANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTP---PVSGS 591
                   :...:.:..|..|.|..|:|          ::.::|:..........|:|   |...:
Human   727 SPPPLAVSRTSSPVRARKLSLTSPLNS----------KIGALDLTTSSSPTTTTQSPAASPPPHT 781

  Fly   592 GNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSS 656
            |.:..:..:.|      ||.::|.|....:..:.:....... ||.:|||:              
Human   782 GQIPLDLSRGL------SSPEQSPGTVEENVDNPRVDLCNKL-KRSIQKAV-------------- 825

  Fly   657 LNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNG 721
                   |.:.|..:....||.::.| :.::.|         :|.|.|........||..|.   
Human   826 -------LESAPADRAGVESSPAADT-TELSPC---------RSPSTPRHLRYRQPGGQTAD--- 870

  Fly   722 GGRLQVNYLNAHIH-RPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEV- 784
                     |||.. .|::|..:.|.:......|.:.:       .::||....|.:.|..:.| 
Human   871 ---------NAHCSVSPASAFAIATAAAGHGSPPGFNN-------TERTCDKEFIIRRTATNRVL 919

  Fly   785 ------VMLTLQEFGIHD--PSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAAR--YYLK 839
                  |....|:|.:::  ..:..:|.|..:.|..::.|.|  ....|:...:|...:  .:||
Human   920 NVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQER--KAAANILRALSQDDQDDIHLK 982

  Fly   840 LNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDE-LFELRSRY 903
            |.|..:  :.|.:..|.       |..|:|.|||.|:||.|...||.|...|::.: ..:|....
Human   983 LEDIIQ--MTDCMKAEC-------FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNE 1038

  Fly   904 GVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHG 968
            ..|.:.|.::..|.....|.|:|....::..|...:::::.:|..|:...|:|.:..|.|.|...
Human  1039 RTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRS 1103

  Fly   969 AVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIH 1033
            |:.||::||.|:..:.:.|.:.||..:.........|:.:..   ...|.:|:..:...||.||.
Human  1104 AIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKN---CNPPAVPYLGMYLTDLAFIE 1165

  Fly  1034 LG--NDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSN 1096
            .|  |.|. :||:||.|:||::..:|.:.....:.|.:       ...|                
Human  1166 EGTPNFTE-EGLVNFSKMRMISHIIREIRQFQQTSYRI-------DHQP---------------- 1206

  Fly  1097 AAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECE 1161
                                                   :|..||....::.|||.|::.||:.|
Human  1207 ---------------------------------------KVAQYLLDKDLIIDEDTLYELSLKIE 1232

  Fly  1162 P 1162
            |
Human  1233 P 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 20/130 (15%)
RasGEFN 279..400 CDD:214571 28/143 (20%)
PDZ_RapGEF2_RapGEF6-like 404..496 CDD:467237 30/170 (18%)
RA_PDZ-GEF1 759..841 CDD:340483 17/92 (18%)
RasGEF 871..1050 CDD:459872 50/181 (28%)
RASGRF2NP_008840.1 PH_RasGRF1_2 19..158 CDD:270081 12/81 (15%)
RhoGEF 247..428 CDD:214619 38/225 (17%)
PH 480..588 CDD:214574 19/108 (18%)
RasGEF_N 638..>686 CDD:459873 12/57 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..809 19/115 (17%)
Regulates proteasomal degradation. /evidence=ECO:0000250 744..752 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..873 12/65 (18%)
REM <901..972 CDD:470601 14/72 (19%)
RasGEF 998..1234 CDD:214539 69/302 (23%)
Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250 1099..1128 9/28 (32%)

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