DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and RALGDS

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_006257.1 Gene:RALGDS / 5900 HGNCID:9842 Length:914 Species:Homo sapiens


Alignment Length:485 Identity:106/485 - (21%)
Similarity:174/485 - (35%) Gaps:141/485 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   843 STEPLVPDELALEL-VRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVP 906
            |.:|..|..:..|. :.|...|.|......:|.|.||.|...|:::.....:..::..|.:.|..
Human   360 SLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKE 424

  Fly   907 ML--------SKFAELVNREMFWVVSEICAEHNIVR---RMKIVKQFIKIARHCKECRNFNSMFA 960
            .|        ::|..:.|     .|...|..:...:   |.::|:.:|::||.|:..:||:|::|
Human   425 HLAPTIRATVTQFNSVAN-----CVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYA 484

  Fly   961 IVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAE------LLAQHP-- 1017
            |:|.|...::.||::|||.:.....|:|..|.::.....|.|..|:|:..|      .|..:|  
Human   485 ILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKR 549

  Fly  1018 -------------IIPFYPIVKKDLTFIHLG-NDTRVDGLINFEKLRM---LAKEVRLLTHMCSS 1065
                         .:|:......||..:... .|.....||||||.|.   :..:::||...|::
Human   550 AQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNN 614

  Fly  1066 -----------------------PYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANA 1107
                                   .|:|...||...:|.||.|                       
Human   615 YSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTL----------------------- 656

  Fly  1108 GQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSI 1172
                  |.||:||                               ::.::|....|:...:.||| 
Human   657 ------RTKKNTA-------------------------------IVKRWSDRQAPSTELSTSGS- 683

  Fly  1173 SHGNTSHRSGGGGSISGG--AGGSSGGGGGGSSS----LNA--------GDQLSIYSHTSSSSAP 1223
            ||..:..:...|..:|.|  |...|....|.|||    :|.        |.:...:...|.||..
Human   684 SHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPE 748

  Fly  1224 NSSLSLRKRHPSSPTLSTTSSTSSTSDHQR 1253
            .|.:|......||.:.||| ..::|..|:|
Human   749 TSGISSASSSTSSSSASTT-PVAATRTHKR 777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999
RasGEFN 279..400 CDD:214571
PDZ_signaling 404..494 CDD:238492
DegQ <422..494 CDD:223343
PDZ_GEF_RA 757..841 CDD:176380
RasGEF 871..1050 CDD:279011 51/211 (24%)
Rhomboid_SP 1252..>1357 CDD:289371 1/2 (50%)
RALGDSNP_006257.1 RasGEFN 112..248 CDD:214571
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..365 2/4 (50%)
RasGEF 382..644 CDD:238087 58/266 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..689 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 728..776 12/48 (25%)
RalGDS_RA 798..883 CDD:176351
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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