DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and rasgrf2a

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_009303357.1 Gene:rasgrf2a / 558859 ZFINID:ZDB-GENE-111128-1 Length:1274 Species:Danio rerio


Alignment Length:1281 Identity:239/1281 - (18%)
Similarity:453/1281 - (35%) Gaps:346/1281 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 LEAEEIDLSGLVESVVDSDEE---------DLAESMDSLTVRDAVRDCLEKDPAERSEEDVEVLL 120
            :|.|::..:.|...:.|.|.|         .|.:|.:.:....:.:|  |:||   ..:.::::.
Zfish   151 METEKVAANQLRTQLEDQDTEIERLKAEIVVLNKSKERMLPFQSFQD--EEDP---DIKKIKMVQ 210

  Fly   121 EFTQGLKAFTNITLAVRRALCS----------VMVFAVVDKAGTVVMSDGEELDSWSVLINGAVE 175
            .|.:|........:.|:..:||          .:||.:|:       ::.|.:...|:|:|..:.
Zfish   211 SFMRGWLCRRKWKIIVQDYICSPHAESMRKRNQIVFNMVE-------AETEYVLQLSILVNCFLR 268

  Fly   176 IEH--ANGSREELQMGDSFGI------LPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRI----Q 228
            ...  |:..:..:...|...|      :..:.:::|:|:   |.....:..:...|.:.|    .
Zfish   269 PLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGL---KARIANWPTLVLADLFDILLPML 330

  Fly   229 HQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQ 293
            :..:|..|.|:    :.:.|.                       |:....|..       ::||:
Zfish   331 NIYQEFVRNHQ----YSLQVL-----------------------ANCKQNRDF-------DKLLK 361

  Fly   294 QLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDR----VTRVVL 354
            | .|.|:..:...:|.| ||:.:| |.|:.:.:       |.::.||...|..:|    ..:..|
Zfish   362 Q-YEANAACEGRMLETF-LTYPMF-QIPRYIIT-------LHELLAHTPHEHVERKSLEFAKSKL 416

  Fly   355 LWVNNHFTDFEADYEMME--------FLEVFEALLE------RKKLLSQLRLLHIACAAKARMRS 405
            ..::....|..:|.|.:.        .:|..:.||:      |:..|.||..:.....:|.|:.|
Zfish   417 EELSKMMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFVRQGSLIQLPSVEKGKLSKVRLGS 481

  Fly   406 CTLTRSSRDEPLNF--------RIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQ 462
            .||.:.:..:...|        |..|| :|.  .:..|.....|..:.:|.        |...|:
Zfish   482 LTLRKEAERQCFLFTKHFLICTRTSGG-KLH--LLKQGGTLSLIECTLIEE--------LDTSDE 535

  Fly   463 IHEVNGQSLDHVTSKRALEILTGTTH----LSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGS 523
            .:...||.|:|:..|..:|...|::.    |:.|.:.......:|.|.:::   ...:|.:::..
Zfish   536 DYNAAGQGLNHLEFKIVVEPADGSSFSVVLLAPSRQEKAAWTSDISQCIDN---IRCNGLMNSVF 597

  Fly   524 GSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPV 588
            .....|..|..|.::  |:||  .|......|....|.:...:|.:||:.||::          :
Zfish   598 EDNSKVTVPHMIKSD--ARLH--KDDVDICFSKTLNSCKVPQIRYASVERLLER----------L 648

  Fly   589 SGSGNMASNFMQQLLQS----------------------------VNNSSAKKSGGNSNSDQQDT 625
            :....::.:|:...|.:                            |...|:.:....|.......
Zfish   649 TDLRFLSIDFLNTFLHTYRIFTTAAVVMDKLADIYKKPFTSIPVRVQYHSSDRLSITSICPDYSL 713

  Fly   626 KGGFMTLAPKRRLQKALAK-------MNLLNKQNHGS---------SLNDSSDTLLNDPKSKLSA 674
            |...:.|...:.|:...|.       .:|.||....|         |:...:.:.::..|..||:
Zfish   714 KITRLALDQSKSLELFFATNQGPWSGEHLNNKSPRLSRKFSSPPPISITSRTSSPIHSRKLSLSS 778

  Fly   675 VSSC-------SSSTQSSING---------------CTVS--------------------GG--- 694
            ..||       |:||.|:.:.               ||.:                    ||   
Zfish   779 PVSCKAGALDLSTSTFSAASSPTSPYNPIICSPPPTCTKAPLDLSRGPSSPELCPSTPEEGGELP 843

  Fly   695 ------GRLYQSQSNPDLTSLNYD-------GGSDAGGNGGGRLQVNYLNAHIHRPS-------- 738
                  |:|.:|.....|.|::.|       ..||:|.....|......:....:|:        
Zfish   844 RIDAFCGKLRRSIRRAVLESVSLDKFIPETPTSSDSGEMSPSRSPSTPRHLRYRQPAGQCPDNSR 908

  Fly   739 -----AASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPS 798
                 |::.....:...|..|....:..|.|.     |..||.:..|..   :|.:....:...|
Zfish   909 CAVSPASAFAIATAAAGHSSPQGFTNPEKSYD-----KEFLIRRAATNR---VLNVLRHWVSKHS 965

  Fly   799 SNFSL-CEVSVGDGGMVKQ-RRLPDQL-QNLAERISFAARYYLKLNDSTEPLVPDELALELVRES 860
            .:|.: .|::.....:::: .|.||.| |.....::..:....:..|.::..:.|  .:::|...
Zfish   966 QDFEMNAELTTAVMALLEEVLRDPDLLPQERKAAVNILSALSQEEQDDSQLKIED--IVQMVDCP 1028

  Fly   861 NVH-FLHLNAYELAIQLTLQDFANFRQIESTEYVDE-LFELRSRYGVPMLSKFAELVNREMFWVV 923
            ... |..|:|.|||.|:||.|...||.|...|::.: ..::......|.:.|.::..|.....|.
Zfish  1029 RAECFESLSAMELAEQITLLDHIVFRNIPYEEFLGQGWMKMDKNERTPYIMKTSQHFNDMSNLVA 1093

  Fly   924 SEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLF 988
            |||.|..::..|...:.:::.:|..|:...|:|.:..|.|.|...|:.||::||.|:..:.:.|.
Zfish  1094 SEIMAHADVSSRAGSIDKWLAVADICRCLNNYNGVLEITSALNRSAIYRLKKTWAKVCKQTKALM 1158

  Fly   989 NDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLG--NDTRVDGLINFEKLRM 1051
            :.||.::.........|:.:..   ...|.:|:..:...||.||..|  |.|. :||:||.|:||
Zfish  1159 DRLQKIVSSEGRFKNLRETLKN---CNPPCVPYLGMYLTDLAFIEEGTPNFTE-EGLVNFSKMRM 1219

  Fly  1052 LAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRK 1116
            ::..:|.:.....:||.    :||:                                        
Zfish  1220 ISHIIREIRQFQQAPYR----IELQ---------------------------------------- 1240

  Fly  1117 KSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEP 1162
                   ||           |..:|....::.|||.|::.||:.||
Zfish  1241 -------PK-----------VTQFLLDKTLVMDEDTLYELSLKIEP 1268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 19/130 (15%)
RasGEFN 279..400 CDD:214571 29/138 (21%)
PDZ_signaling 404..494 CDD:238492 22/101 (22%)
DegQ <422..494 CDD:223343 17/75 (23%)
PDZ_GEF_RA 757..841 CDD:176380 15/86 (17%)
RasGEF 871..1050 CDD:279011 51/181 (28%)
Rhomboid_SP 1252..>1357 CDD:289371
rasgrf2aXP_009303357.1 PH_RasGRF1_2 19..155 CDD:270081 1/3 (33%)
PH 24..130 CDD:278594
RhoGEF 244..425 CDD:279015 39/234 (17%)
PH 478..585 CDD:214574 25/117 (21%)
PH 489..584 CDD:278594 21/105 (20%)
RasGEF_N 635..>683 CDD:279012 7/57 (12%)
REM <935..1007 CDD:295342 15/79 (19%)
RasGEF 1033..1265 CDD:238087 70/297 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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