Protein Alignment PDZ-GEF and rapgef1a

DIOPT Version :9

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: XP_005166961.1
• Gene: rapgef1a / 558635
• ZFINID: ZDB-GENE-081105-26
• Length: 1085
• Species: Danio rerio
• Alignment Length: 607
• Identity: 143/607 - (23%)
• Similarity: 223/607 - (36%)
• Gaps: 206/607 - (33%)

  Fly   542 KLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSV 606
            :::|.|||                  .||.|..|     .||..||           .|:.|.|.
Zfish   519 EVYGLSDS------------------FSSSDETL-----PPPALPP-----------KQRQLASS 549

  Fly   607 NNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTL-LNDPKS 670
            :::|...|..:|.|.|               ||:.::          |....::..|| |:...|
Zfish   550 HSASPSSSSSSSLSCQ---------------LQQCVS----------GPGPGETESTLSLSASNS 589

  Fly   671 KLSAVSSCSSSTQSSINGCTVSGGG----RLYQS-QSNPDLTSLNYD---GGSDAGGNGGGRLQV 727
            .|:...|....|..|.|.   .||.    .||.| |:|.|:|..|.|   |..|:..:
Zfish   590 SLNREGSLPVPTSESAND---EGGEGEYVNLYSSNQANGDVTLSNGDSFCGAEDSPQD------- 644

  Fly   728 NYLNAHIHRPSAA-----------STLTTNSTQSHLLPDY----------------PD------H 759
               :|..|....|           |.||:.......|.|:                ||      .
Zfish   645 ---SAIEHSKDPADREGWKQKCVDSDLTSEEVDELCLIDHDEIMSRITLKQENDDGPDVRAGSGD 706

  Fly   760 VLKVYKADQTCKYVLIYKET---------TAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVK 815
            :|.|:..:...|..::|.|.         |..:::......:      :.|||...|      :|
Zfish   707 ILLVHATETDRKDRVLYCEAFLTTYRTFLTPEDLIKKLRYRY------TRFSLSSDS------IK 759

  Fly   816 QR----------RLPDQL---------------------------------QNLAERISFAARYY 837
            ||          |:.|:|                                 :|:.:::.  .:..
Zfish   760 QRASKNTFFVLVRVVDELCLVELTEDILKQLMELVFNLLCKGELTLARVLRKNILDKVQ--QKKL 822

  Fly   838 LKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTE---YVDELFEL 899
            |:..:|.:.|....:|   .|...:|  ...::|:|.||||.|...|.:||..|   :..|..|.
Zfish   823 LQYTNSLKTLAARGVA---ARPGTLH--DFRSHEIADQLTLLDAELFYKIEIPEVLLWAKEQNEE 882

  Fly   900 RSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSG 964
            :|    |.|::|.|..|...:||.|.|..:.....|.|::.:||||.:|.::..||||..||:|.
Zfish   883 KS----PNLTQFTEHFNNMSYWVRSIIILQEKAQDREKLLLKFIKIMKHLRKLNNFNSYLAILSA 943

  Fly   965 LGHGAVSRLRQTWEKLPSKYQRLFNDLQD---LMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVK 1026
            |....:.||.  |:|..|:      .|::   |:|.|.:...||..::.   .:.|.||:..::.
Zfish   944 LDSAPIRRLE--WQKQTSE------GLEEYCTLIDSSSSFRAYRAALAD---VEPPCIPYLGLIL 997

  Fly  1027 KDLTFIHLGNDTRVDGLINFEK 1048
            :||||:||||...::|.|||.|
Zfish   998 QDLTFVHLGNPDHIEGKINFSK 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	20/141 (14%)
		RasGEF	871..1050	CDD:279011	65/184 (35%)
		Rhomboid_SP	1252..>1357	CDD:289371
rapgef1a	XP_005166961.1	RasGEFN	696..837	CDD:214571	22/154 (14%)
		RasGEF	844..1073	CDD:214539	66/193 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940