DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and sos1

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_001076462.1	Gene:	sos1 / 556286	ZFINID:	ZDB-GENE-070209-128	Length:	713	Species:	Danio rerio

Alignment Length:	835	Identity:	164/835 - (19%)
Similarity:	267/835 - (31%)	Gaps:	312/835 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   764 YKAD-QTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLA 827
            ||.| |...|::...|..:.:::.|.                      |..|:..|
Zfish   120 YKIDHQVSVYIVAVLEYISADILKLA----------------------GNYVRNIR--------- 153

  Fly   828 ERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEY 892
                   .|.:...|.|..:..|::.:::          |:..|:|.||||.:...:|.::.:|.
Zfish   154 -------HYEISQQDITVAMCADKVLMDM----------LHPIEIARQLTLLESDFYRAVQPSEL 201

  Fly   893 VDELF-----ELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKEC 952
            |..::     |:.|    |.|.:..........|:...|....|:..|:.:|.:.|:|.:..:|.
Zfish   202 VGSVWTKEDKEINS----PNLLRMIRHTTNLTLWLEKCIVETENVEERVSVVSRIIEILQVFQEL 262

  Fly   953 RNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDP--SRNMSKYRQLVSAELLAQ 1015
            .|||.:..:||.:....|.||..|:|::||:.:::..:..:|.:.  .:.::|.|.:       .
Zfish   263 NNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQRKILEEAHELSEDHYKKYLAKLRSI-------N 320

  Fly  1016 HPIIPFYPIVKKDLTFIHLGNDTRV----DGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELK 1076
            .|.:||:.|...::.....||...:    ..||||.|.|.:|:....:....:.||.|
Zfish   321 PPCVPFFGIYLTNILKTEEGNPDFLKRHGTELINFSKRRKVAEITGEIQQYQNQPYCL------- 378

  Fly  1077 GQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYL 1141
                                                      ....:.:|.||.          |
Zfish   379 ------------------------------------------RVENDIRKFFEN----------L 391

  Fly  1142 NSLKILSDE---DLLHKFSLECEPAHGST-------YSGSISHGNTSHRSGGGGSISGGAGGSS- 1195
            |.::.:.::   |.|...|||.||.:..|       ||..:.              |.|...|:
Zfish   392 NPMEDMMEKEFTDYLFNKSLEIEPRNARTLPRFAKKYSCPLK--------------SPGVRPSAV 442

  Fly  1196 --GGGGGGSSSLNAGDQLSIYS-------HTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDH 1251
              |.....:...|...::| ||       .:|::|||||     .|.|.:|..::.:||.:.|..
Zfish   443 RPGAMRHPTPLQNEPRKIS-YSRIPDSETESSAASAPNS-----PRTPLTPPPASAASTDTCSVF 501

  Fly  1252 QRRQMHNNGPKFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTP 1316
            .              |||              :|..||........|.|..|       ||
Zfish   502 D--------------SPQ--------------QPSSPFHSNSECVFAPVALP-------HG---- 527

  Fly  1317 SPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTPAPPPPLPSVDLSL 1381
                    |.:|:|:::.                |.:          .:|.|..|||:|
Zfish   528 --------PRSSSVSSMM----------------GFL----------RNDDPPVPPPVP------ 552

  Fly  1382 ESSSVTTFRDLPLRKSVTSGSISSCDSGYVHQQQHYHLQYQQQQQQNSSQHEPSPPVYTAADCRL 1446
                       |.|:..::.:.||                   ..:..|.|..|||...
Zfish   553 -----------PRRRPESAPAESS-------------------PSKMMSTHLDSPPAIP------ 581

  Fly  1447 LQQISNNAVTRNLNSPCQSTNTPP-STPTPPPNQPTAT--------IQLSAPPTAAAYMHARSQH 1502
                .....:..:.||..|...|| |.|..||.:|..|        :.|..||..     .|:..
Zfish   582 ----PRQPTSSKVYSPRYSLTDPPESPPLLPPREPVRTPDVFCSSPLHLQPPPPG-----RRAPE 637

  Fly  1503 QQLQQQQQSLAMPP------PPPPPYNVPPLGSIYSHHQGTAG-SRHLNHMHGKT 1550
            .|.....|:.:..|      |.|||  .||||........||| ..|:..:..||
Zfish   638 LQAFFPPQTPSPSPLGPRKHPEPPP--EPPLGPPVPPRLSTAGPPAHIPKLPPKT 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	11/77 (14%)
		RasGEF	871..1050	CDD:279011	47/189 (25%)
		Rhomboid_SP	1252..>1357	CDD:289371	15/104 (14%)
sos1	NP_001076462.1	Histone	58..169	CDD:278551	13/86 (15%)
		H2A	97..183	CDD:305064	16/110 (15%)
		RasGEF	174..412	CDD:238087	61/317 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030