DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and rasgrf2b

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_009300046.1 Gene:rasgrf2b / 553520 ZFINID:ZDB-GENE-060504-1 Length:1275 Species:Danio rerio


Alignment Length:906 Identity:173/906 - (19%)
Similarity:309/906 - (34%) Gaps:259/906 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 LLQQLVEENS-MTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVL 354
            |:..:.|||| :|.|..::.....|:   .:.....||.|:...:.|:.....:.|.:|:|.:..
Zfish   591 LMTSVFEENSKVTVPHMIKSDARLHK---DDVDICFSKTLNSCKVPQIRYASVERLLERLTDLRF 652

  Fly   355 LWVNNHFTDFEADYEMMEFLEVFE----ALLERKKLLSQLRLLHIACAAKARMRS---CTLTRSS 412
            |.:     ||     :..||..:.    |.:..:||....:....:...:.:..|   .::|...
Zfish   653 LSI-----DF-----LNTFLHTYRIFTTATVVMEKLADIYKKPFTSIPVRVQYHSFDRLSITSIC 707

  Fly   413 RDEPLNFRIVGGYELRGVAI--ATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVT 475
            .|..|..|.:...:.:.:.:  ||..                              |.:|.|||.
Zfish   708 PDYSLKIRKIALDQSKSLELFFATNQ------------------------------NNRSGDHVN 742

  Fly   476 SK--RALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICAN 538
            .|  |.....:....||||.:::                              ..||:.:....:
Zfish   743 DKSPRLCRKFSSPPPLSISSRTS------------------------------SPVRTRKLSLNS 777

  Fly   539 DIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLL 603
            .|....|..|.:|...|:.|:...|:             |..:||                    
Zfish   778 PIGSKVGILDLSTTSSSAASSPTSAN-------------PTISPP-------------------- 809

  Fly   604 QSVNNSSAKK----SGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTL 664
            .|.||:::|.    |.|.|.|..:.:.|.....|...|:.....|:.        .|:.      
Zfish   810 PSNNNNNSKPPLDLSRGQSPSSPEQSPGALDDNAEVPRIDALCGKLR--------RSIR------ 860

  Fly   665 LNDPKSKLSAVS-------SCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNY-DGGSDAGGNG 721
                ::.|.:||       |..:|....|:.|         :|.|.|  ..|.| ..|.....| 
Zfish   861 ----RAVLESVSLDKFIPESPQASEPGEISPC---------RSPSTP--RHLRYRQSGVQTAEN- 909

  Fly   722 GGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVM 786
             .|..|:        |::|..:.| :...|..|...::      :::||....|.:....:.|  
Zfish   910 -SRCSVS--------PASAFAIAT-AAAGHSSPPVFNN------SERTCDKEFIIRRAATNRV-- 956

  Fly   787 LTLQEFGIHDPSSNFSL-CEVSVGDGGMVKQ-----RRLPDQLQNLAERISFAARYYLKLNDSTE 845
            |.:....:...|.:|.: .|:.:|...::::     ..||.:.:..|..:|     .|..:|..:
Zfish   957 LNVLRHWVSKHSQDFEMNGELKMGVICLLEEVLRDPDLLPQERKATANILS-----ALSQDDQDD 1016

  Fly   846 PLVPDELALELVRESNVH-FLHLNAYELAIQLTLQDFANFRQIESTEYVDE-LFELRSRYGVPML 908
            ..:..|..|::....... |..|:|.|:|.|:||.|...||.|...|::.: ..:.......|.:
Zfish  1017 AQLKIEDILQMAECPKAECFESLSAMEIAEQITLLDHIVFRSIPYEEFLGQGWMKTDKTERTPYI 1081

  Fly   909 SKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRL 973
            .|.::..|.....|.|:|.:..::..|...:::::.:|..|:...|:|.:..|.|.|...|:.||
Zfish  1082 MKTSQHFNDMSNLVASQIMSHTDVGSRAGSIEKWVAVADICRCLNNYNGVLEITSALNRSAIYRL 1146

  Fly   974 RQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLG--N 1036
            ::||.|:..:.:.|.:.||..:.........|:.:..   ...|.:|:..:...||.||..|  |
Zfish  1147 KKTWAKVCKQTKALMDKLQKTVSSEGRFKNLRETLKN---CNPPCVPYLGMYLTDLAFIEEGTPN 1208

  Fly  1037 DTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGT 1101
            .|. :||:||.|:||::..:|.:.....:||.:                                
Zfish  1209 FTE-EGLVNFSKMRMISHIIREIRQFQQTPYRI-------------------------------- 1240

  Fly  1102 VIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEP 1162
                               ...||           |..||....::.|||.|:..||:.||
Zfish  1241 -------------------EHQPK-----------VTQYLLDKTLIMDEDTLYDLSLKIEP 1271

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999
RasGEFN 279..400 CDD:214571 23/113 (20%)
PDZ_signaling 404..494 CDD:238492 18/96 (19%)
DegQ <422..494 CDD:223343 13/75 (17%)
PDZ_GEF_RA 757..841 CDD:176380 14/89 (16%)
RasGEF 871..1050 CDD:279011 48/181 (27%)
Rhomboid_SP 1252..>1357 CDD:289371
rasgrf2bXP_009300046.1 PH_RasGRF1_2 19..154 CDD:270081
PH 24..129 CDD:278594
RhoGEF 243..424 CDD:279015
PH 476..584 CDD:214574
PH 476..583 CDD:278594
RasGEF_N 634..>682 CDD:279012 12/57 (21%)
REM <938..1010 CDD:295342 13/78 (17%)
RasGEF 1036..1272 CDD:214539 69/302 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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