DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and RAPGEFL1

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_057423.2	Gene:	RAPGEFL1 / 51195	HGNCID:	17428	Length:	662	Species:	Homo sapiens

Alignment Length:	762	Identity:	165/762 - (21%)
Similarity:	269/762 - (35%)	Gaps:	250/762 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 GGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDML 574
            |||..|.|..:.|..|.:..:|..|:.                                  :...
Human    37 GGGPGGGGGPAGGQRSLQRRQSVSRLL----------------------------------LPAF 67

  Fly   575 LDQPDCAPPQTPPVSGSGNMASNFMQQ---------LLQSVNNSSAKKSGG-----NSNSDQQDT 625
            |.:|...|...||....|...:...::         .|:.|........||     :|.|..:.:
Human    68 LREPPAEPGLEPPPEEEGGEPAGVAEEPGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDELS 132

  Fly   626 KGGFMTLAPKRRLQKALAKMNLLNK---QNHGSSLNDS--SDTLLNDPKSKLSAVSSCSSSTQSS 685
            .|..:|..|...|.......:|||:   :..|.:..||  ||.||:|    :....|....|:..
Human   133 PGEPLTSPPWAPLGAPERPEHLLNRVLERLAGGATRDSAASDILLDD----IVLTHSLFLPTEKF 193

  Fly   686 INGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQ------VNYLNAHIHRPSAASTLT 744
            :.                 :|.......|...|..|.||.|      :::|:.:      ...|.
Human   194 LQ-----------------ELHQYFVRAGGMEGPEGLGRKQACLAMLLHFLDTY------QGLLQ 235

  Fly   745 TNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAH--------------EVVMLTLQEFGIH 795
            ......|::.|.               |:||.|:.:.:              |.|.|.:.|.. .
Human   236 EEEGAGHIIKDL---------------YLLIMKDESLYQGLREDTLRLHQLVETVELKIPEEN-Q 284

  Fly   796 DPS-------------------------SNFSLCEVSVGDGGMVKQR-----RLPDQLQNLAERI 830
            .||                         |:...|.|.:.|...|..|     .:.|.|.::.|::
Human   285 PPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKL 349

  Fly   831 SFA--------------------------------------ARYYLKLNDSTEPLV--PDELALE 855
            .::                                      :..:....||.|.||  |:|:.:.
Human   350 QYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVS 414

  Fly   856 LVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFE-LRSRYGVPMLSKFAELVNREM 919
             ..::.:|  .:...::|..||...:..||.:...|:||.:|. .|.|.....|....:..:...
Human   415 -PGDTEIH--RVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVT 476

  Fly   920 FWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKY 984
            .||.:|:.......:|.:::|:|||||..||:.::..|.:|:|.||.:.||||||.||||||.|:
Human   477 HWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKF 541

  Fly   985 QRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKL 1049
            :.||...::|.||.||...||:::|.   .:.|:|||.|::.|||||:|.|:.|.||||:|.|||
Human   542 KNLFRKFENLTDPCRNHKSYREVISK---MKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKL 603

  Fly  1050 RMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKR 1114
            ..:|::||.:....|.|..|                   .|.||.::.
Human   604 HSVAEKVRTIRKYRSRPLCL-------------------DMEASPNHL----------------- 632

  Fly  1115 RKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECE 1161
                                 :.|||:...:::.:::||.:.|.:.|
Human   633 ---------------------QTKAYVRQFQVIDNQNLLFELSYKLE 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	19/165 (12%)
		RasGEF	871..1050	CDD:279011	72/179 (40%)
		Rhomboid_SP	1252..>1357	CDD:289371
RAPGEFL1	NP_057423.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..149		25/145 (17%)
RAPGEFL1	NP_057423.2	RasGEF	420..658	CDD:214539	89/299 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810