Protein Alignment PDZ-GEF and Rgl

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Alignment Length: 911
• Identity: 186/911 - (20%)
• Similarity: 304/911 - (33%)
• Gaps: 309/911 - (33%)

  Fly   546 RSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSS 610
            :|.:...:|..::..|||.|..|.:.|.                      ||..:|    |||::
  Fly    25 KSHTCAYQLQDLTGYNRALMPPLDNTDF----------------------SNAWRQ----VNNNT 63

  Fly   611 AKKSGG-----NSNSDQQDTKGG---------------FMT------------LAPKRRLQKALA 643
            ..:|..     .....|||.|..               .||            .|.:||.:.|.|
  Fly    64 TSQSCAYHQQRQQQQQQQDAKDSKRHYHHHTCPRQRKKSMTPVEPTHLCQKHQEAKQRRSRSASA 128

  Fly   644 KMNLLNKQNHGSSLNDSSDTLLNDPK---SKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPD 705
            |.. .|...|.....|.|..:||..:   :.|..:.:|:.:|..::             |:...|
  Fly   129 KPR-RNSSYHSYDDLDVSSAVLNAERKVVASLKYLCACTGATLRNL-------------SKKTKD 179

  Fly   706 LTSLNYDGGSDAGGNGGGRLQVN-----YL-NAHIHRPSAASTLTTNSTQSH------------- 751
            |.:.||..........|...:.|     || ....|||:..::..::...||
  Fly   180 LHAKNYTYTKPTWRLWGEEHEKNAIFTVYLKKVRYHRPTPTASNDSDDEISHLEWETVRVRFVKA 244

  Fly   752 ----------------LLPDYPDHVLKVYKADQTCKYV---LIYKETTAHEVVMLTLQE------ 791
                            |...:.:..|..|:...|.|.|   |..:....||..:..|::
  Fly   245 ATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQ 309

  Fly   792 ---------FGIHDPSSNFSLCEVSVG-DGGMVKQRRLPDQL--QNLAERISFAAR------YYL 838
                     ..||:......:..:.|. ||       .|:..  .||.:.::||.:      .::
  Fly   310 VMDPAYDPHASIHEQHKKTLVSALHVWLDG-------FPEDWHEDNLQQILAFATKRLKRSDLHI 367

  Fly   839 KLNDSTEPLVPDEL-------------------------------------ALELVRESN----- 861
            |:.:..|.|:...|                                     :.:|..:.|
  Fly   368 KVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLS 432

  Fly   862 -----------VHFL------HLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYG----V 905
                       .|||      |:.....|.|||..|...|:::...:.:...:..|...|    |
  Fly   433 PMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSETVV 497

  Fly   906 PMLSKFAELVNREMFWVVSEICAEHNIVRRMK------IVKQFIKIARHCKECRNFNSMFAIVSG 964
            ..:::|    |..:|.|||.|     ::.|:|      .:.::|.||:..:..:||:|:.||:|.
  Fly   498 ATINQF----NAVLFRVVSSI-----LIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISA 553

  Fly   965 LGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHP------------ 1017
            |...::.||.:.||.||.:...:|.:|.::.....|....|:::..|..|::|
  Fly   554 LNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQ 618

  Fly  1018 -------------IIPFYPIVKKDLTFIHLGNDTRV--DGLINFEKLR----MLAKEVRLL---- 1059
                         .||:......|||.||..|...:  :.||||:|.|    :|| :::||
  Fly   619 KLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLA-QIKLLQGAA 682

  Fly  1060 -----------THMCSS--------PYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAA 1105
                       .|..:|        .::|...||....:|..::.|.|   .|.:|..|.:.
  Fly   683 NTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPPPPAPRKSVVSTN---TSLTNTTASST--- 741

  Fly  1106 NAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSG 1170
                |:|...:|:.:..:.......:|....:.:..:|.....|.|:.|:        |.|..|.
  Fly   742 ----ASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQ--------HASLMSA 794

  Fly  1171 SISHGNTS-HRSGGGGSISG--------GAGGSSGGGG---GGSSSLNAGDQLSIYSHTSSSSAP 1223
            |.|..|.| ..|..||..||        |.|..|.|.|   |||..:||  ||...|..:..|||
  Fly   795 SSSVSNLSLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINA--QLVQPSSGTPHSAP 857

  Fly  1224 N 1224
            :
  Fly   858 D 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237
		RA_PDZ-GEF1	759..841	CDD:340483	20/108 (19%)
		RasGEF	871..1050	CDD:459872	54/215 (25%)
Rgl	NP_001261814.1	REM	246..378	CDD:100121	23/138 (17%)
		RasGEF	454..719	CDD:214539	65/274 (24%)
		RA_RalGDS_like	858..946	CDD:340449	0/1 (0%)