DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and rgl1

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_991200.2	Gene:	rgl1 / 402933	ZFINID:	ZDB-GENE-040426-1816	Length:	804	Species:	Danio rerio

Alignment Length:	769	Identity:	167/769 - (21%)
Similarity:	266/769 - (34%)	Gaps:	207/769 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   695 GRLYQSQSNPDLTSLNYDGGSDAG----GNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPD 755
            |.:|    |..|..:.....::.|    |..|.||...      |..|...|....|.::..|..
Zfish    58 GAIY----NVTLKRVQIQQAANKGARWLGAEGDRLPPG------HTVSQLETCKIRSIRAGTLER 112

  Fly   756 YPDHVLKVYKADQTCKYVLIYKET-----TAHEVVMLTLQEFG-IHDPSSNFSLCEVSVGDGGMV 814
            ..:.:|..: .|....|..|:..|     :...|:.|.|..:| ..|.....|.|:  .|:....
Zfish   113 LVETLLTAF-GDNDLTYTSIFLSTYRAFASTQSVLELLLDRYGSFEDCEGERSQCQ--TGESRKA 174

  Fly   815 KQRRLPDQL--------QNLAERISFAARYYL-----KLNDSTEPLVPDELALELVR-------E 859
            .::.|...|        ::..|..|:.:.:.:     |....:||:...:..||.:|       |
Zfish   175 VRKALASILRAWLDQCPEDFQEPPSYPSLHRVLGFLQKAMPGSEPMRRAQSLLEQLRVQASLENE 239

  Fly   860 SNVHFLHLNAYELA----IQLTLQ-DFANFR---QIESTEYVDELF------------------E 898
            :...|.::|.:.|.    :::.|| ||.:|.   ..|...|:|.|.                  :
Zfish   240 TEGGFQYINPFCLGEDEEVEIDLQEDFFSFEVDLVAEQLTYMDALLFKKVVPHHCLGSIWSQRDK 304

  Fly   899 LRSRYGVPMLSKFAELVNREMFWVVSEICAEHNI--VRRMKIVKQFIKIARHCKECRNFNSMFAI 961
            ...:...|.:.......|.....|||.|..:..|  ..|.:|::::|.||:.|:..:||:|:.||
Zfish   305 KDGKQSAPTIRATITQFNAVTACVVSTILRQRQIRPHLRARIIQRWIDIAQECRIRKNFSSLRAI 369

  Fly   962 VSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAE--------------- 1011
            ||.|....:.||::||..:.....::|.:|.|:.....|....|:|:..|
Zfish   370 VSALQSNPLYRLKRTWASVAKDSMQMFEELSDIFSDQNNYLTSRELLMREGTSKFASLDSCAKDH 434

  Fly  1012 -------------LLAQHPIIPFYPIVKKDLTFIHLGNDTRVD-GLINFEKLRM---LAKEVRLL 1059
                         :.|....||:......|||.:......:|: |||||||.|.   :..:::||
Zfish   435 QKRSQKRLQLQKDMGAMQGTIPYLGTFLTDLTMLDTALPDQVEGGLINFEKRRREFEVIAQIKLL 499

  Fly  1060 THMCSSPYDLLSILELKGQSPSNALF----SLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTA 1120
            ...|:| |.|         :|..|..    |..|.|..:|...:..|....         ..|..
Zfish   500 QSACNS-YCL---------TPDPAFLRWFKSQPQYSEEESYVLSCEVEGLG---------DNSPT 545

  Fly  1121 APNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGG 1185
            :|.|:|     .||:|:     ||..|                 |:..:.:.|....|.||...|
Zfish   546 SPKPRK-----SMVKRL-----SLLFL-----------------GNDSTNTSSPVRESPRSPPTG 583

  Fly  1186 SISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSD 1250
            |                    :|:.:...|.:||.|:|:.|..:...|.....|...|.:||.:
Zfish   584 S--------------------SGESMDSVSVSSSDSSPSESDGMTPTHSIDAHLKKLSESSSCN- 627

  Fly  1251 HQRRQMHNNGPKFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFST 1315
                .:|:......|||       .|:|.:|             .|:.|  ||.:|..:......
Zfish   628 ----SLHSMDTSSSTAS-------ASISLAS-------------PTLPG--PPCNHRRSISLTPL 666

  Fly  1316 PSPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTPA 1369
            .||    |||......|.|   :...|..|.....||....::|...|...|||
Zfish   667 MSP----TSPGFPPAYNTQ---AQDACIIRVSLEQGNGNLYKSIMLTSQDKTPA 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	18/102 (18%)
		RasGEF	871..1050	CDD:279011	56/235 (24%)
		Rhomboid_SP	1252..>1357	CDD:289371	23/104 (22%)
rgl1	NP_991200.2	REM	109..232	CDD:100121	23/125 (18%)
		RasGEF	266..535	CDD:238087	65/278 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..611		13/66 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..676		14/61 (23%)
		RalGDS_RA	684..769	CDD:176351	9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810