DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and rapgef1b

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	XP_021324455.1	Gene:	rapgef1b / 394101	ZFINID:	ZDB-GENE-040426-1001	Length:	1204	Species:	Danio rerio

Alignment Length:	662	Identity:	146/662 - (22%)
Similarity:	232/662 - (35%)	Gaps:	260/662 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 KLHGRSD--STTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQ 604
            :::|.:|  |::|.:.:.:|.....:               .||..||             :|.|
Zfish   582 EVYGLNDSYSSSDSIPASAADPHERV---------------PPPALPP-------------KLRQ 618

  Fly   605 SVNNSSAKKSGGNSNSDQQDTKGGFMTLAP----KRRLQKALAKMNLLNKQNHGSSLNDSSDTLL 665
            ..:|::......:|::        |.||.|    ...::.||           |.||:.||
Zfish   619 LASNTTTFPPSSSSSA--------FSTLPPPAGLPEEVEPAL-----------GLSLSVSS---- 660

  Fly   666 NDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYL 730
                |.||..:|.::...|...|.|.||                   ...|.||...|.|..:.|
Zfish   661 ----SFLSGHASLTTPVSSEPVGLTNSG-------------------RALDGGGVSNGSLTSSLL 702

  Fly   731 NAHIHRPSAAS---TLTTNSTQSHLLPDYPDHVLKVYKADQT--CKYVLIYKETTA-----HEVV 785
            :..:..||.:|   :|.|::::|               .|::  .:||.:|..|.|     |...
Zfish   703 SLAVCLPSESSLSDSLLTSASES---------------IDESGEGEYVNLYSSTQANGENTHRTE 752

  Fly   786 MLT----LQEFGIHDPSSNFSLC-------EVSVGDGGMVKQRRLPDQLQNLAERISFAA----- 834
            .|:    ||:...|.||||....       |.|.|....|.:..|.|. .::..||:..|
Zfish   753 SLSCDDVLQDHSPHIPSSNSKEALTKERPKEASHGHIDDVDELSLIDH-NDIMNRITLKAENDDG 816

  Fly   835 ----------------------------------RYYLKLNDSTEPL------------------ 847
                                              |.::...|..:.|
Zfish   817 PDVRAGSVDILLVHATETDRKDLVLYCEAFLTTYRTFITPEDLIKKLHHRYTRFCHSPDTFKKRV 881

  Fly   848 ----------VPDELAL-----ELVRE----------------------------------SNVH 863
                      |.|||.|     :::|:                                  .::|
Zfish   882 SKNTFFVLVRVVDELCLVELTEDILRQLMDLVFRLVCNGELSLARVLRKNILDKVEQKRLLQHMH 946

  Fly   864 FLH----------------LNAYELAIQLTLQDFANFRQIESTE---YVDELFELRSRYGVPMLS 909
            .|.                ..::|:|.||||.|...|.:||..|   :..|..|.:|    |.|:
Zfish   947 TLRPLAALGVSARPGTLHDFRSHEIADQLTLLDAELFYKIEIPEVLLWAKEQNEEKS----PNLT 1007

  Fly   910 KFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLR 974
            :|.|..|...:||.|.|..:.....|.|::.:||||.:|.::..||||..||:|.|....:.||.
Zfish  1008 QFTEHFNNMSYWVRSIIIQQEKAQDREKLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE 1072

  Fly   975 QTWEKLPSKYQRLFNDLQD---LMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGN 1036
              |:|..|:      .|::   |:|.|.:...||..: ||:  :.|.||:..::.:||||:||||
Zfish  1073 --WQKQTSE------GLEEYCTLIDSSSSFRAYRAAL-AEV--EPPCIPYLGLILQDLTFVHLGN 1126

  Fly  1037 DTRVDGLINFEK 1048
            ...::|.:||.|
Zfish  1127 PDFIEGKVNFSK 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	25/140 (18%)
		RasGEF	871..1050	CDD:279011	66/184 (36%)
		Rhomboid_SP	1252..>1357	CDD:289371
rapgef1b	XP_021324455.1	Atrophin-1	<287..538	CDD:331285
		RasGEFN	815..953	CDD:214571	11/137 (8%)
		RasGEF	963..1192	CDD:214539	66/191 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940