DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and CG5522

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	146/739 - (19%)
Similarity:	229/739 - (30%)	Gaps:	274/739 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   865 LHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRY-GVPMLSKFAELVNREMFWVVSEICA 928
            |.:.|..||.|:||.||..|.||:..|.....:..:.:: ..|.:..|.:..|...||.|.||..
  Fly   163 LRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILN 227

  Fly   929 EHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQD 993
            .....:|.:|:..|||:|:...|..|.:|:|||:|.:...::.||.:||..|..|.:..|:.|.|
  Fly   228 AEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSD 292

  Fly   994 LMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVRL 1058
            :.....|.:..|..:.:..|   |.||:..:...||.:|.|.:..: .||...::...:...:|:
  Fly   293 IFSDQDNWANLRSYLESLRL---PCIPYLGLFLTDLIYIDLAHPHK-GGLEPEQRRNKMNNILRV 353

  Fly  1059 LTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPN 1123
            :::...|.|..|.    |.::....|.|:..:...|:
  Fly   354 ISNYQQSNYKHLQ----KHEATQKYLTSIRYIEELQN---------------------------- 386

  Fly  1124 PKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGGSIS 1188
               :|||.|                     :|.||..|||..|
  Fly   387 ---IFEEDQ---------------------YKRSLNLEPASPS---------------------- 405

  Fly  1189 GGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSP--TLSTTSSTSSTSDH 1251
                      |..|||.::.:..::...|.:....|.|       |:..  ::...|.|.....|
  Fly   406 ----------GPSSSSCSSKESFNVEVVTPALGCLNLS-------PAKTIGSMRMASGTKFVPGH 453

  Fly  1252 QRRQMHNNGPKFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTP 1316
              |:..:.|.||.::|                      :||:.:.......
  Fly   454 --RKCRSLGTKFRSSS----------------------LPRNFAEKCQCCI-------------- 480

  Fly  1317 SPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSD----------TPAPP 1371
                |:.:|....::|.:|.     |  ||:.  |.|    |.|  :|||          .|:..
  Fly   481 ----VMIAPGIGTISNKRCR-----C--RRIF--GKI----ATH--NHSDGHPHHLHLELDPSQV 526

  Fly  1372 PPLPSV--DLSLESSSVTTFRDLPLRKSVTSGSISSCDSGYVHQQQHYHLQYQQQQQQNSSQHEP 1434
            .|...:  |..||.|...:..||   .|:.|.....||
  Fly   527 QPRHHLLDDSVLEHSDALSQADL---TSLESAEGIMCD--------------------------- 561

  Fly  1435 SPPVYTAADCRLLQQISNNAVTRNLNSPCQSTNTPPSTPTPPPNQPTATIQLSAPPTAAAYMH-- 1497
                :|.:||.|:.                                         |.|||.||
  Fly   562 ----FTGSDCDLMS-----------------------------------------PEAAAAMHGC 581

  Fly  1498 ---------------ARSQHQQLQQQQQSLAMPPPPP-----------PPYNVPPLGSIYSHHQG 1536
                           |..|...||....||...||..           .|..|.||...|:|...
  Fly   582 VRRKTVQKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFKREPCKVCPLDGWYAHVSD 646

  Fly  1537 TAGSRHLNHMHGKTTGPQERWFPD 1560
            ....::...:..:|.|...|:..|
  Fly   647 NTKHKNTFELCHRTLGTVYRFRTD 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380
		RasGEF	871..1050	CDD:279011	53/179 (30%)
		Rhomboid_SP	1252..>1357	CDD:289371	16/104 (15%)
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	70/296 (24%)
		PH_RalGPS1_2	578..692	CDD:270120	20/93 (22%)
		PH	578..685	CDD:278594	20/93 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467927
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940