DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and Sos

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_476597.2 Gene:Sos / 34790 FlyBaseID:FBgn0001965 Length:1596 Species:Drosophila melanogaster


Alignment Length:1840 Identity:345/1840 - (18%)
Similarity:589/1840 - (32%) Gaps:683/1840 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 GLVESVVDSDEEDLAESMDSLTVRDAVRDCLEK-----DPAERSEEDVEVLLEFTQGLKAFTNIT 133
            |.|..:.|.|..|..:..::...|......|:|     .|...::||..:.:|         .:.
  Fly    47 GGVAGLQDCDGYDFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVE---------KLC 102

  Fly   134 LAVRRALCS-VMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPT 197
            |.:...||: .:..:|.|....|..|....:|.|::           |.::|.:.......:|||
  Fly   103 LRLLAMLCAKPLPHSVQDVEEKVNKSFPAPIDQWAL-----------NEAKEVINSKKRKSVLPT 156

  Fly   198 --MDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTD 260
              :..|..:.|::.|.|                          ...:.|:|.|.|..|     .|
  Fly   157 EKVHTLLQKDVLQYKID--------------------------SSVSAFLVAVLEYIS-----AD 190

  Fly   261 SAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLV---EENSMTDP----------TYVEDFLL 312
            .....|......|...:.:..:.:....:|:|..::   |.:.:..|          ||      
  Fly   191 ILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQSEAHILPSPLSLPAQRASATY------ 249

  Fly   313 THRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADY-EMMEFLEV 376
                     :|...:|:|.....|.|.|    :..||.|..|:.:.:...:.|..: .:|:..||
  Fly   250 ---------EETVKELIHDEKQYQRDLH----MIIRVFREELVKIVSDPRELEPIFSNIMDIYEV 301

  Fly   377 FEALL-ERKKLLSQLRLLHIACAAKARMRSC-------------------TLTRSSRDEPLN--- 418
            ...|| ..:.::...:.....|..     ||                   ..:::|||...|   
  Fly   302 TVTLLGSLEDVIEMSQEQSAPCVG-----SCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLS 361

  Fly   419 -------------FRIVGGYEL-RGVAIATGNAAVGI-YISHVEPGSKAQDVGLKRGDQIHEVNG 468
                         ||....|.| :.:.:...:|.|.. ||.|::..|.:|| .::..:|:     
  Fly   362 KPGASSLTTAGHGFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQD-DIESFEQV----- 420

  Fly   469 QSLDH------------VTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEH----GGGTAGSG 517
            |.|.|            ::.:|.:.: :|.....::::..    :|:...:||    ..|...:.
  Fly   421 QGLLHPLHCDLEKVMASLSKERQVPV-SGRVRRQLAIERT----RELQMKVEHWEDKDVGQNCNE 480

  Fly   518 SISAGS----GSFKSVRSPRRICAND----IAKLHGRSDSTTDELSSVSASNRAHMVRLSS---- 570
            .|...|    ||.|.:.|.|::...|    :.|.:.:..:.       ||...|:..||..    
  Fly   481 FIREDSLSKLGSGKRIWSERKVFLFDGLMVLCKANTKKQTP-------SAGATAYDYRLKEKYFM 538

  Fly   571 --VDMLLDQPD---------CAPPQTPPVSGSGNMAS---NFMQQLLQSVNNSSAKKSGGNSNSD 621
              || :.|:||         .||...||:..:...|.   ::|..||..:..|...:   :.:|.
  Fly   539 RRVD-INDRPDSDDLKNSFELAPRMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDR---HLDSI 599

  Fly   622 QQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSI 686
            .||.:.......|...:.|              .::.||.|.::.:.:         .|:....|
  Fly   600 LQDIERKHPLRMPSPEIYK--------------FAVPDSGDNIVLEER---------ESAGVPMI 641

  Fly   687 NGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHR-PSAASTLTTNSTQS 750
            .|.|               |..|                 :..|..||:. |:...|..|     
  Fly   642 KGAT---------------LCKL-----------------IERLTYHIYADPTFVRTFLT----- 669

  Fly   751 HLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVK 815
                              |.:|.     .:..:::.|.::.|.|.|||..:. ...:.|.|||..
  Fly   670 ------------------TYRYF-----CSPQQLLQLLVERFNIPDPSLVYQ-DTGTAGAGGMGG 710

  Fly   816 ---------------QRRLPDQLQNLAERISFAARYYLK---LNDSTEPLVPDEL---------- 852
                           :|...:.:|.:..|:....|:::.   .:...:|::.::|          
  Fly   711 VGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLEHVNGK 775

  Fly   853 --------ALELVRESN------------------------------VHFLHLNAYELAIQLTLQ 879
                    .|::|:..|                              :..|.|:..|||.||||.
  Fly   776 SMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLL 840

  Fly   880 DFANFRQIESTEYVDELF-----ELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIV 939
            :|..::.::.:|.|...:     |::|    |.|.|..:.......|:...|....|...|:.|:
  Fly   841 EFEMYKNVKPSELVGSPWTKKDKEVKS----PNLLKIMKHTTNVTRWIEKSITEAENYEERLAIM 901

  Fly   940 KQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKY 1004
            ::.|::.....|..|||.:.:||:.:|..:|.|||.|::.||.:|::...:.::|.|.  ::.||
  Fly   902 QRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELSDD--HLKKY 964

  Fly  1005 RQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDG--LINFEKLRMLAKEVRLLTHMCSSPY 1067
            ::.:.:   ...|.:||:.....::..:..||...:..  ||||.|.|.:|:.:..:....:.||
  Fly   965 QERLRS---INPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQNQPY 1026

  Fly  1068 DLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQ 1132
                              .||:                   ::||            ::.||:  
  Fly  1027 ------------------CLNE-------------------ESTI------------RQFFEQ-- 1040

  Fly  1133 MVRRVKAYLNSLKILSDE---DLLHKFSLECEP-------------AHGSTYSGSI-----SHGN 1176
                    |:....|||:   |.|:..||..||             .|....|..|     :..|
  Fly  1041 --------LDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTN 1097

  Fly  1177 TSHR-SGGGGSISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSS---- 1236
            :|.: |....|::..|..||                     |::|.|..|:.||   |.||    
  Fly  1098 SSSKLSNSTSSVAAAAAASS---------------------TATSIATASAPSL---HASSIMDA 1138

  Fly  1237 PTLSTTSSTSSTSDHQRRQMHNNG----------PKFGTAS----PQAVKKMLSLSESSKIRPHQ 1287
            ||.:..::.|.|...::...||..          |:..|:|    ||..:...:..|.|...||.
  Fly  1139 PTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQNNGEVSVPAPHL 1203

  Fly  1288 PFVP------RHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSPSPCSHRR 1346
            |..|      .:.||:|                :.|...||.|||.......|..|..:|.:   
  Fly  1204 PKKPGAHVWANNNSTLA----------------SASAMDVVFSPALPEHLPPQSLPDSNPFA--- 1249

  Fly  1347 LASGGNIIPSRAIHERSHSDTPAPPPPLPSVDLS---------------LESSSVTTFRDLPLRK 1396
                              |||.|||.|||.:.:|               ..|.:.:|...:.|..
  Fly  1250 ------------------SDTEAPPSPLPKLVVSPRHETGNRSPFHGRMQNSPTHSTASTVTLTG 1296

  Fly  1397 SVTSGSISSCDSGY----VHQQQ--------HY------HLQY---------------------- 1421
            ..|||....|..|:    .||.|        |.      :::|                      
  Fly  1297 MSTSGGEEFCAGGFYFNSAHQGQPGAVPISPHVNVPMATNMEYRAVPPPLPPRRKERTESCADMA 1361

  Fly  1422 QQQQQQNSSQHEP-----SPP-----------------------VYTAADCRLLQQISNNAVTRN 1458
            |::|..::....|     |||                       .:......||...|:..:.||
  Fly  1362 QKRQAPDAPTLPPRDGELSPPPIPPRLNHSTGISYLRQSHGKSKEFVGNSSLLLPNTSSIMIRRN 1426

  Fly  1459 ---------LNSPCQSTNTPPST-------------PTPPPNQPTATIQLSAPP----------- 1490
                     .:.|.|:...|.||             |.|.|..|.|:...:..|           
  Fly  1427 SAIEKRAAATSQPNQAAAGPISTTLVTVSQAVATDEPLPLPISPAASSSTTTSPLTPAMSPMSPN 1491

  Fly  1491 --------TAAAYMHARSQHQQLQQQQQSLAMPPPPPPPYNVPPLGSIYS-HHQGTAGSRHL-NH 1545
                    |:::|.|.....||.|||...                 :||| |||..|  .|| :|
  Fly  1492 IPSHPVESTSSSYAHQLRMRQQQQQQTHP-----------------AIYSQHHQHHA--THLPHH 1537

  Fly  1546 MHGKTTGPQE------RWFP 1559
            .|...:.|.:      .:||
  Fly  1538 PHQHHSNPTQSRSSPKEFFP 1557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 18/111 (16%)
RasGEFN 279..400 CDD:214571 23/135 (17%)
PDZ_signaling 404..494 CDD:238492 24/138 (17%)
DegQ <422..494 CDD:223343 16/85 (19%)
PDZ_GEF_RA 757..841 CDD:176380 16/101 (16%)
RasGEF 871..1050 CDD:279011 50/185 (27%)
Rhomboid_SP 1252..>1357 CDD:289371 25/124 (20%)
SosNP_476597.2 Histone 90..216 CDD:278551 29/176 (16%)
H2A 155..>196 CDD:305064 12/71 (17%)
RhoGEF 249..432 CDD:238091 40/212 (19%)
PH_SOS 476..586 CDD:269963 27/117 (23%)
PH 482..587 CDD:278594 27/112 (24%)
RasGEFN 637..791 CDD:214571 31/214 (14%)
RasGEF 825..1062 CDD:238087 69/304 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467925
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
43.970

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