DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and C3G

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster

Alignment Length:	1262	Identity:	251/1262 - (19%)
Similarity:	426/1262 - (33%)	Gaps:	408/1262 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPTSIAGTGVVVGSST--------------TINRPELHQKCN----RGSHSS-----DTS----- 48
            |..|:.||||:..|:.              |....::.::.|    |||||:     |||
  Fly   473 PGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERDILEQHNVNPMRGSHSTESILRDTSPPPKP 537

  Fly    49 --------------------SAYSG-------SDTMASNYASSL---EAEEIDLSGLVESVVDSD 83
                                ||.:|       |.|..||.||.|   ::..|.|:..::  ..|:
  Fly   538 PLPNRASNPPPLPPKRRSQPSASAGTVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLD--CSSN 600

  Fly    84 EEDLAESMDSLTVR----DAVRDCLEKDPA---ERSEEDVEVLLEFTQGLKAFTNITLAVRRALC 141
            ...|...:|.|:||    |....| ..|.|   .|.|||.:   :..|.|::|..:...:...:.
  Fly   601 ISLLNYGVDRLSVRSRSPDENSQC-SFDSALNHSREEEDQQ---QQHQHLRSFPKLAAMMDEDMD 661

  Fly   142 SVMVF--AVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHR 204
            .::.:  |:.||..|.:.:.|           |...:....|...|
  Fly   662 KMVSYSAAIDDKTQTPLSTGG-----------GIAGVAGGTGGAGE------------------- 696

  Fly   205 GVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTD---SAGSGG 266
            ||......|                 ||.|:.||.:|:|||.| .|.|: ....||   .:.:..
  Fly   697 GVAAAASGD-----------------GETNSNRHSNESGFVSM-REFRT-STQTTDYSVQSSTKS 742

  Fly   267 SATGASASLNMKRGHVVIRGTPERLLQQLV---------EENSMTDPTYVEDFLLTHRIFIQNPQ 322
            |::.:..:.::.....|...:..:.:.|||         ..:|.|..|
  Fly   743 SSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCTTTT----------------- 790

  Fly   323 EVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLL 387
             .:|.....:...:|:..:.|:.:...|.             .||
  Fly   791 -TSSSTTTGYGSSEVEQLQQQQQQQTTTT-------------PAD-------------------- 821

  Fly   388 SQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVG-GYELRGVAIATGNAAVGIYISHVEPGSK 451
                 |..|...|:..|| :|||  .|.|      | |.||..|..::|      :.||  ..|:
  Fly   822 -----LAPALPPKSIQRS-SLTR--HDSP------GVGDELDEVQSSSG------WASH--RSSQ 864

  Fly   452 AQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGS 516
            ::...|::...:|.:|..  .|..|...|:......|..|......|               |||
  Fly   865 SEVAELRQLSPLHHLNHH--PHTASAGQLQQWHSKHHSLIEGPRLQL---------------AGS 912

  Fly   517 GSISAGSGSF------------KSVRSPRRICANDIAKL--HGRSDSTTDELSSVSASNRAHMVR 567
            ||.||.....            |.:.:...||:.....:  |..:....:...::|.|...:::.
  Fly   913 GSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHACNISRNISHSQTMNIMP 977

  Fly   568 LS-SVDMLLDQPDCAPPQTPPVSGSGNM-ASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFM 630
            :| .:...|:.|...||:......:.:| ||..:|.::.:....|.|.:.|.:.|
  Fly   978 MSKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSPKPTLGENGS---------- 1032

  Fly   631 TLAPKRRLQKALAKMN---------------LLNKQNHGSSLNDSSDTLLND---PKSKLSAVSS 677
            |..|..|:.....::|               :|:...:.|:::|......:.   |.:::.....
  Fly  1033 TGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSED 1097

  Fly   678 CSSSTQSSINGCTVSGGGRLYQSQSNPDLTS------------LNYDGGSDA------------- 717
            .||:....|.      ..::.:.|..|...|            .|.|...:|
  Fly  1098 ASSADNQPIT------TPQVLEEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEV 1156

  Fly   718 ----------GGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQ-TCK 771
                      ....|..::..|::|.|...|....:..|:.....:..:...:..:...:: |.:
  Fly  1157 NITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHR 1221

  Fly   772 YVLIY------KETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLA--- 827
            |...:      |:..|.|...|.::.  ::|.:|.                 .|..||.:|.
  Fly  1222 YTYFFCQVQDNKQKAAKETFALLVRV--VNDLTST-----------------DLTSQLLSLLVEF 1267

  Fly   828 --ERISFAARYYLKL--NDSTEPLVPDELALELVRESNVH------------------------- 863
              :.:.....|..||  |...|.:.       |.:|..|:
  Fly  1268 VYQLVCSGQLYLAKLLRNKFVEKVT-------LYKEPKVYGFVGELGGAGSVGGAGIAGSGGCSG 1325

  Fly   864 ---------FLHLNAYELAIQLTLQDFANFRQIESTE---YVDELFELRSRYGVPMLSKFAELVN 916
                     .|.|.:.|:|.|:||.|...|.:||..|   :..:..|.:|    |.|:||.|..|
  Fly  1326 TAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKS----PNLNKFTEHFN 1386

  Fly   917 REMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLP 981
            :..:|..|:|....:...|.|.|.:||||.:|.::..|:||..|::|.|..|.:.||.  |:|..
  Fly  1387 KMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE--WQKGI 1449

  Fly   982 SKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGN-DTRVDGLIN 1045
            ::..|.|   ..|:|.|.:...|||.::.   ...|.||:..::.:||||:|:|| |....|:||
  Fly  1450 TEEVRSF---CALIDSSSSFRAYRQALAE---TNPPCIPYIGLILQDLTFVHVGNQDYLSKGVIN 1508

  Fly  1046 FEKLRMLAKEVRLLTHM-----CSSPY 1067
            |.|   ..::..::.:|     |:.|:
  Fly  1509 FSK---RWQQYNIIDNMKRFKKCAYPF 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999	15/110 (14%)
		RasGEFN	279..400	CDD:214571	15/129 (12%)
		PDZ_signaling	404..494	CDD:238492	24/90 (27%)
		DegQ	<422..494	CDD:223343	17/72 (24%)
		PDZ_GEF_RA	757..841	CDD:176380	15/97 (15%)
		RasGEF	871..1050	CDD:279011	64/182 (35%)
		Rhomboid_SP	1252..>1357	CDD:289371
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	26/161 (16%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	69/213 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467922
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.970