DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and Rasgef1a

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_232315.7 Gene:Rasgef1a / 312664 RGDID:1305836 Length:489 Species:Rattus norvegicus


Alignment Length:493 Identity:106/493 - (21%)
Similarity:188/493 - (38%) Gaps:131/493 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   697 LYQSQSNPDLTSLNYDG--------------GSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNS 747
            |.:.::.|. ||:.:.|              |...||...|...:.:.:..         ||:.|
  Rat     3 LERQEAMPQ-TSVVFSGTLGPNCNRPVQPGMGERGGGASSGSKDLIFQDGR---------LTSGS 57

  Fly   748 TQS---HLLPD---YPDHVL--------KVY--------KADQTC-------------------- 770
            .::   ||:|.   |||...        :|:        :..|.|                    
  Rat    58 LEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFS 122

  Fly   771 -KYVLIYKETT-------AHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLA 827
             |.|.:.||.|       ..|..|..|:..     :...:.|:   .:.|.|| :.:...:|:|.
  Rat   123 TKIVQLLKEWTEAFPYDFQDEKAMAELKAI-----AHRVTQCD---EENGTVK-KAITQMIQSLL 178

  Fly   828 ERISFAARYYL-KLNDSTEPLVPDE----LALELVRESNVHFLHLNAYELAIQLTLQDFANFRQI 887
              :|.|||..| :|.:.....|.|:    .|.....:.::..:..:...||.|||..:......|
  Rat   179 --LSLAARSQLQELREKLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSI 241

  Fly   888 ESTE------YVDELFELRSRYGVP---MLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFI 943
            ...:      ::|.|...|.|..:.   .|..:....|.....|.:|:|.......|.::::.||
  Rat   242 RPEDLMQIISHMDSLDNHRCRGDMTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFI 306

  Fly   944 KIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLV 1008
            .:||.|....|||||.||:||:....|:||::||.|:.:   ..|:.|:..||||.|...||..:
  Rat   307 DVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKT---AKFDVLEHHMDPSSNFCNYRTAL 368

  Fly  1009 --------SAELLAQHPIIPFYPIVKKDLTFIH-LGNDTRVDGLINFEKLRMLAKEV-------- 1056
                    :|....:..:||.:.:..||:.|:| :..:....|.|||:|...:::::        
  Rat   369 QGATQRSQTANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPSGHINFKKFWEISRQIHEFMTWTR 433

  Fly  1057 ---------RLLTHMCSSPY---DLLSILELKGQSPSN 1082
                     ::.:::.::|.   :.|.|...:.:.|.|
  Rat   434 VECPFEKDKKIQSYLLTAPIYSEEALFIASFESEGPEN 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999
RasGEFN 279..400 CDD:214571
PDZ_signaling 404..494 CDD:238492
DegQ <422..494 CDD:223343
PDZ_GEF_RA 757..841 CDD:176380 24/128 (19%)
RasGEF 871..1050 CDD:279011 57/196 (29%)
Rhomboid_SP 1252..>1357 CDD:289371
Rasgef1aXP_232315.7 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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