DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and Rasgrp1

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	XP_038960368.1	Gene:	Rasgrp1 / 29434	RGDID:	3539	Length:	818	Species:	Rattus norvegicus

Alignment Length:	895	Identity:	185/895 - (20%)
Similarity:	313/895 - (34%)	Gaps:	235/895 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   650 KQNHGSSLNDSSDTLLNDPKSKLSAVSSCSS-STQSSINGCT----VSGGGRLYQSQSNPDLTSL 709
            |..|||...         ||.:|.|.|:.|. ..|.|:...|    :...|.|.:..|..||..
  Rat    36 KPCHGSRAG---------PKGRLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLID- 90

  Fly   710 NYDGGSDAGGN---GGGRLQVNYLNAHIHRPSAASTL--TTNSTQSHLLPDYPDHVLKVYKADQT 769
            :.....||.||   ....||| .|..|....|:|..|  ..|..:..|..:.|...||:
  Rat    91 SCIQSFDADGNLCRSNQLLQV-MLTMHRIIISSAELLQKLMNLYKDALEKNSPGICLKI------ 148

  Fly   770 CKYV--------LIYKETTAHEVVMLTLQEF-GIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQN 825
            |.:|        :::|...:   :..|::|| .:...:...|.|.:.  |...:..|   |..:.
  Rat   149 CYFVRYWITEFWIMFKMDAS---LTSTMEEFQDLVKANGEESHCHLI--DTTQINSR---DWSRK 205

  Fly   826 LAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIEST 890
            |.:||        |.|.|.:            |:.::.|.||...||:..||..:|.:||:|..:
  Rat   206 LTQRI--------KSNTSKK------------RKVSLLFDHLEPEELSEHLTYLEFKSFRRISFS 250

  Fly   891 EYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNF 955
            :|.:.|.....:.. |.:.:...|.|....||...:.:......|.::..:||.:|:...:.:||
  Rat   251 DYQNYLVNSCVKEN-PTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNF 314

  Fly   956 NSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIP 1020
            |::.|::.||.|.::|||::|...:|.:..::..::.:|:...||...||:....   ..|..||
  Rat   315 NTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGE---CTHFKIP 376

  Fly  1021 FYPIVKKDLTFIHLG-NDTRVDGLINFEKLRMLAKEVRLLTHM--CSSPYDL------LSILELK 1076
            ...:..|||..::.. .|...||.:|.:||..|...:..|..:  .:.|.|.      |..|.|.
  Rat   377 ILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQDVAPPLDANKDLVHLLTLSLD 441

  Fly  1077 GQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQ-MVRRV-KA 1139
            .....:.::.|:.....:::.|  ..:..:.....:......:..|:||.:.:..| ||..| |.
  Rat   442 LYYTEDEIYELSYAREPRNHRA--PPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKN 504

  Fly  1140 Y-LNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISGGAGGSSGGGGGGSS 1203
            | |:....:|.|: ..|.      |....:|..:.   ...|.|
  Rat   505 YDLDQDGYISQEE-FEKI------AASFPFSFCVM---DKDREG--------------------- 538

  Fly  1204 SLNAGDQLSIYSHTSSSSAPNSSLSLR-------------------------------------- 1230
             |.:.|:::.|...:||......|...
  Rat   539 -LISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNC 602

  Fly  1231 ------------KRHPSSPTLSTTSSTS----------STSD--HQRRQ---MHNNGPKFGTASP 1268
                        |:...||.:||.:.:|          .|.|  |...:   :..||.....:..
  Rat   603 HKQCKDLVVFECKKRSKSPAVSTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEVVDHSEE 667

  Fly  1269 QAVKKMLSLSESS-KIRPHQPFVPRHGST-------MAGVIPPLHHMHAAHGFSTPSPGGVVTSP 1325
            ...:.::.|..|| ||.........|.:|       :.|.:||.|.              |:|||
  Rat   668 SKDRTIMLLGVSSQKISVRLKRTVAHKTTQTESFPWVGGEMPPGHF--------------VLTSP 718

  Fly  1326 ATSA----VANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTPAPPPPLPSVDLSLESSSV 1386
            ..||    ..:...:|.|||.          ::..||..:..:.::...|.|    :|.|.   :
  Rat   719 RKSAQGALYVHSPASPCPSPA----------LVRKRAFVKWENKESLIKPKP----ELHLR---L 766

  Fly  1387 TTFRDLPLRKSVTSGSISSCDSGYVHQQQHYHLQYQQQQ----QQNSSQH 1432
            .|:::|....:..     ..|:..:..|    |:|.|:|    |...|.|
  Rat   767 RTYQELEQEVNTL-----RADNDALKIQ----LKYAQKQIESLQLGKSNH 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	18/92 (20%)
		RasGEF	871..1050	CDD:279011	47/179 (26%)
		Rhomboid_SP	1252..>1357	CDD:289371	23/119 (19%)
Rasgrp1	XP_038960368.1	RasGEFN	77..199	CDD:214571	31/134 (23%)
		RasGEF	224..460	CDD:214539	59/239 (25%)
		EF-hand_7	501..550	CDD:404394	14/80 (18%)
		C1_RASGRP1	563..617	CDD:410410	1/53 (2%)
		cc_RasGRP1_C	760..814	CDD:412086	14/64 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910