Protein Alignment PDZ-GEF and Ralgdsl1

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: NP_001099427.2
• Gene: Ralgdsl1 / 289080
• RGDID: 1308947
• Length: 803
• Species: Rattus norvegicus
• Alignment Length: 793
• Identity: 153/793 - (19%)
• Similarity: 264/793 - (33%)
• Gaps: 251/793 - (31%)

  Fly   640 KALAKMNLLNK-QNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLY----- 698
            :.::|:.|..| :|.|..|.|....:....|::.|::.......:.          |.:|
  Rat    11 QVVSKVKLSTKVENPGHWLVDDHARIWEVLKTEESSIQDWGEEVEE----------GAVYHVTLK 65

  Fly   699 ----QSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDH 759
                |..:|.....|..:|.....|               |..|...|....:.::..|....::
  Rat    66 RVQIQQAANKGARWLGVEGDQLPPG---------------HTVSQYETCKIRTIKAGTLEKLVEN 115

  Fly   760 VLKVYKADQTCKYVLIYKET-----TAHEVVMLTLQEFG------IHDPSSNFS----------- 802
            :|..: .|....|:.|:..|     :..||:.|.|..:|      ..|..|..|
  Rat   116 LLTAF-GDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTGPHWEDDGSQSSPESKAVIRNAI 179

  Fly   803 ------------------------------LCEVSVGDGGMVKQRRLPDQLQ--------NLAER 829
                                          |.::..|.....:.:.|.:|.|        .|...
  Rat   180 ASILRAWLDQCAEDFREPPHFPCLQKLLEYLKQMMPGSDPERRAQNLLEQFQKQDVDSDNGLLNT 244

  Fly   830 ISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVD 894
            |||:               |:| ..||....:......:...:|.|||..|...|:::.....:.
  Rat   245 ISFS---------------PEE-EEELESGGSAELTTFSEDLVAEQLTYMDAQLFKKVVPHHCLG 293

  Fly   895 ELFELRSR----YGVPMLSKFAELVNREMFWVVSEICAEHNI--VRRMKIVKQFIKIARHCKECR 953
            .::..|.|    :..|.:.......|.....|||.|....::  .:|.::::::|.||..|:..:
  Rat   294 CVWSRRDRKENKHLAPTIRATISQFNALTKCVVSTILGSKDLKTQQRARVIEKWINIAHECRILK 358

  Fly   954 NFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPI 1018
            ||:|:.||||.|...::.||::.|..:|.....:|.:|.::.....|     .|.|.|||.:...
  Rat   359 NFSSLRAIVSALQSNSIYRLKKAWAAVPKDRMLMFEELSEIFSDHNN-----HLTSRELLMKEGT 418

  Fly  1019 IPFYPI----------------VKKDL-----TFIHLGN--------DTRVD-----GLINFEKL 1049
            ..|..:                ::||:     |..:||.        ||.:.     |||||||.
  Rat   419 SKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKR 483

  Fly  1050 RM---LAKEVRLLTHMCSSPYDLLSILELKGQSPSNAL---FSLNQMSASQSNAAAGTVIAANAG 1108
            |.   :..:::||...|:| |.:         ||....   |...|:...:.:.|....|.|.|
  Rat   484 RREFEVIAQIKLLQSACNS-YCM---------SPDQKFIQWFQRQQLLTEEESYALSCEIEAAA- 537

  Fly  1109 QATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSIS 1173
                   ..||.:|.|:|     .||:|:     ||..|. .||:
  Rat   538 -------DASTTSPKPRK-----SMVKRL-----SLLFLG-SDLI-------------------- 564

  Fly  1174 HGNTSHRSGGGGSISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPT 1238
            .|:|..:.....:.||.:|.|.             |.:|:.|..|:.|......:.....|..|.
  Rat   565 PGSTPTKEQPKSTASGSSGESM-------------DSVSVSSCESNHSEAEEGSATPMDTPDEPQ 616

  Fly  1239 LSTTSSTSSTSDHQRRQMHNNG----------PKFGTASPQAVKKMLSLSESSKIRPHQPFVPRH 1293
            ...:.|:||.|.......:::|          |.....:|:..|:.:|::
  Rat   617 KKLSESSSSCSSIHSMDTNSSGMSSLINPLSSPPACNNNPKMHKRSVSVT--------------- 666

  Fly  1294 GSTMAGVIPPLHH 1306
             |..:.|:||:::
  Rat   667 -SITSTVLPPVYN 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237
		RA_PDZ-GEF1	759..841	CDD:340483	22/141 (16%)
		RasGEF	871..1050	CDD:459872	54/218 (25%)
Ralgdsl1	NP_001099427.2	RasGEFN	100..231	CDD:214571	18/131 (14%)
		RasGEF	263..532	CDD:238087	65/283 (23%)
		RA_RGL	682..768	CDD:340730