Protein Alignment PDZ-GEF and CG7369

DIOPT Version :9

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: NP_649415.2
• Gene: CG7369 / 2768961
• FlyBaseID: FBgn0037188
• Length: 680
• Species: Drosophila melanogaster
• Alignment Length: 969
• Identity: 194/969 - (20%)
• Similarity: 309/969 - (31%)
• Gaps: 384/969 - (39%)

  Fly   253 SIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIF 317
            |.||..:.:.|..||...|:.:||:|.....|.|.|.            |..:......:||:..
  Fly     4 SNGGLSSATNGRSGSTGSATINLNLKGHERTIVGVPG------------TGASSATTTSITHKTL 56

  Fly   318 IQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLE 382
            .....:.::...|        ||::.....|:                             ||||
  Fly    57 PDLKTQRSNSACH--------AHESLSALRRI-----------------------------ALLE 84

  Fly   383 R--KKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNF---RIVGGYELRGVAIATGNAAVGIY 442
            :  :||||.       .||::|:    |.:.:|::.|.:   |:..| .|:.:
  Fly    85 KPPEKLLSY-------GAAQSRI----LGQEAREDFLVYSEGRLHSG-PLQSL------------ 125

  Fly   443 ISHVEPGSKAQDVGLKRGDQIHEV---NGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIM 504
            |:|:.|              .||.   .|.....:.|.|            :.|:.:.| ..:|.
  Fly   126 IAHMVP--------------THEYYPDEGFIFAFLLSAR------------LFVRPHEL-LAQIS 163

  Fly   505 QALEH-------GGGT---AGSG-----SISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDEL 554
            |..||       ||..   ||.|     .:|..|.|..:.|......|:..::|..|....|:..
  Fly   164 QTWEHQQQDVGTGGDVVDDAGQGPGRTMMVSINSASPLTQRKGSAAAASHSSELEPRLQQRTNTQ 228

  Fly   555 SSVSASNRAHMVRLSSV-----------DMLLDQPDCAPPQTPPVSGS-GNMASNFMQ------- 600
            .|..     |.:||.|.           :.|:.|......:...:..| |...|..:|
  Fly   229 RSAQ-----HCIRLLSEWIEIFPYDFRDERLMQQVRILARKCVYIDNSLGKQVSRILQLLVSRLT 288

  Fly   601 ------QLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHG--SSL 657
                  :.||::::..|:       |.||.                        :..:||  :.|
  Fly   289 TLEQYEEFLQTISSEEAQ-------SQQQQ------------------------HHHHHGHHNHL 322

  Fly   658 NDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGG 722
            :::..|.|               .:.|..||  .||||......||           |.:.|:
  Fly   323 HNAFQTFL---------------GSSSHANG--ASGGGGSASGTSN-----------SSSSGH-- 357

  Fly   723 GRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVML 787
                          .|:|||..:.||...     ||.|..:.....:|.::       ||::..:
  Fly   358 --------------TSSASTSNSISTTPQ-----PDDVFGIMDMCPSCAHL-------AHQLTAI 396

  Fly   788 TLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDEL 852
            .|:...             .:|....|:               :||..|..:..|.:
  Fly   397 ELERLS-------------HIGPEEFVQ---------------AFAKDYQQQAKDGS-------- 425

  Fly   853 ALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPMLSKFAELVNR 917
                 ||:|..........     :|.|....|.:||                     :.:..||
  Fly   426 -----REANNSKCSGGGGG-----SLNDMKKTRNLES---------------------YVQWFNR 459

  Fly   918 EMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPS 982
            ..:...|||.......:|::|::.:|:.||.|....||||:.||::||....:.||::||.|:.|
  Fly   460 LSYLTASEIVKYPKKKQRVRIIEYWIETARECFNIGNFNSLMAIIAGLNLAPIGRLKKTWAKVQS 524

  Fly   983 KYQRLFNDLQDLMDPSRNMSKYRQLVSAELL--------AQHPIIPFYPIVKKDLTFIHLGNDTR 1039
               ..|:.|:..|||:.|.:.||..:.|.:.        .:..||||:.:..|||.|::.|...|
  Fly   525 ---AKFSVLEHQMDPTSNFNSYRSTLKAAMWRSEGATEERERIIIPFFSLFVKDLYFLNEGCSNR 586

  Fly  1040 V-DGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVI 1103
            : :..|||||...|||:|                :|.......|..|.
  Fly   587 LPNNHINFEKCSQLAKQV----------------MEFNEWKKVNCPFE----------------- 618

  Fly  1104 AANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEP 1162
                            ..||             |.|||.:..:| :|:.|...|.||||
  Fly   619 ----------------RLPN-------------VIAYLQNSAVL-NENTLSMASFECEP 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571	19/122 (16%)
		PDZ_signaling	404..494	CDD:238492	14/95 (15%)
		DegQ	<422..494	CDD:223343	10/74 (14%)
		PDZ_GEF_RA	757..841	CDD:176380	12/83 (14%)
		RasGEF	871..1050	CDD:279011	54/187 (29%)
		Rhomboid_SP	1252..>1357	CDD:289371
CG7369	NP_649415.2	RasGEF_N	116..261	CDD:279012	37/189 (20%)
		RasGEF	388..649	CDD:214539	87/400 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940