DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and Rapgefl1

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_001074394.1	Gene:	Rapgefl1 / 268480	MGIID:	3611446	Length:	662	Species:	Mus musculus

Alignment Length:	716	Identity:	173/716 - (24%)
Similarity:	254/716 - (35%)	Gaps:	231/716 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   511 GGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLL 575
            ||..|.|....|.|....:|..:|                           |..:.|| .:...|
Mouse    32 GGPGGGGGPGGGGGPAGGLRPLQR---------------------------RQSVSRL-LLPAFL 68

  Fly   576 DQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSSAKKSGG------------------------ 616
            .:|...|...|||...|.          :.:..|....|||
Mouse    69 REPPTEPGLEPPVEEEGG----------EPLGVSEEPGSGGPCWLQLEEVPGPGPIGSGVPLRSP 123

  Fly   617 NSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNK---QNHGSSLNDS--SDTLLNDPKSKLSAVS 676
            :|.|..:.:.|..:...|...|.......:|||:   :..|.:..||  ||.||:|    :....
Mouse   124 SSYSSDELSPGEPLASPPWAPLGAPERPEHLLNRVLERLAGGTTRDSSASDILLDD----IVLTH 184

  Fly   677 SCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAAS 741
            |....|:            :..|......:.|.|.:|....|                 |..|..
Mouse   185 SLFLPTE------------KFLQELHQYFVQSRNVEGPEGLG-----------------RKQACL 220

  Fly   742 TLTTNSTQSHLLPDY---------PDHVLKVYKADQTCKYVLIYKETTAH--------------E 783
            .|..     |.|..|         ..|::|..       |:||.|:.:.:              |
Mouse   221 ALLL-----HFLDTYQGLLQEEEGAGHIIKEL-------YLLIMKDESLYQDLREDTLRLHQLVE 273

  Fly   784 VVMLTLQEFGIHDPS-------------------------SNFSLCEVSVGDGGMVKQR-RLPDQ 822
            .|.|.:.|.. ..||                         |:...|.|.:.|...|..| ||...
Mouse   274 TVELKIPEES-QPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSAS 337

  Fly   823 LQNLAERISFAARYYLKLNDSTEPLV-PDELALELVRESNVHFL----------------HL--- 867
            :|::...::      .||..|.||.. .|.|.|..|..|....|                ||
Mouse   338 VQDILGSVT------EKLQYSEEPAEREDALILVAVASSGEKVLLQPTEDCVFTTLGINSHLFAC 396

  Fly   868 --NAYELAIQL----------------TLQDFAN---------FRQIESTEYVDELFE-LRSRYG 904
              ::||..:.|                ..:|.||         ||.:...|:||.:|. .|.|..
Mouse   397 TRDSYEALVPLPEEVQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE 461

  Fly   905 VPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGA 969
            ...|....:..:....||.:|:.......:|::::|:|||||..||:.::..|.:|:|.||.:.|
Mouse   462 TANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAA 526

  Fly   970 VSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHL 1034
            |||||.||||||.|::.||...:.|.||.||...||:::|.   .:.|:|||.|::.|||||:|.
Mouse   527 VSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISK---MKPPLIPFVPLILKDLTFLHE 588

  Fly  1035 GNDTRVDGLINFEKLRMLAKEVR---------LLTHMCSSPYDLLS---ILELKGQSPSNALFSL 1087
            |:.|.||||:|.|||..:|::||         |...|.:||:.|.:   :.:.:.....|.||.|
Mouse   589 GSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVIDNQNHLFEL 653

  Fly  1088 N 1088
            :
Mouse   654 S 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	22/123 (18%)
		RasGEF	871..1050	CDD:279011	74/204 (36%)
		Rhomboid_SP	1252..>1357	CDD:289371
Rapgefl1	NP_001074394.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..149		27/154 (18%)
Rapgefl1	NP_001074394.1	RasGEF	420..658	CDD:214539	85/238 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810