DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and efc25

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_596123.1	Gene:	efc25 / 2540248	PomBaseID:	SPBC336.03	Length:	987	Species:	Schizosaccharomyces pombe

Alignment Length:	686	Identity:	152/686 - (22%)
Similarity:	256/686 - (37%)	Gaps:	199/686 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   511 GGTAGSGSISAGSGSFKS-VRSPRRICANDIAK------------LHGRSDSTTDE-----LSSV 557
            ||...:..:||.|.:::: :..|   |..::.|            :...||...:|     .|::
pombe   352 GGKWTNNGLSAVSSAYRTRLLEP---CLPELDKCVWFLLKNCDEFIENFSDFADEEYVFEICSTI 413

  Fly   558 SASNRAHMVRLSSVDMLL----DQPDCAPPQTPPVSGSGNMASNFMQQ-----------LLQSVN 607
            ::.:.....:|.|.||.:    |..:|            ..|:||..|           ||..:.
pombe   414 TSHSEQIFNKLESWDMSIYFDKDLSEC------------EQATNFAVQSYFVTKQRCYDLLTDLV 466

  Fly   608 NSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNK---------------------- 650
            .||......:||.        |.|: |......|:|...|...
pombe   467 CSSQDLMMEHSND--------FSTM-PTMIASIAVAFQTLFENVCDFLKVRAALVDEMQELATKE 522

  Fly   651 -QNHGSSLNDSSDTLLNDP-------------KSKLSAVSSCSSST----QSSINGCTVSGG--- 694
             :|..|:.|.:.|   ::|             .|..:|||..|..|    ::|:....:...
pombe   523 FENKFSNANTAKD---DEPARQTNKGTTRISRSSDFTAVSEMSKDTLTLGRNSLQSILMLDNLLT 584

  Fly   695 GRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQ--VNYL--NAHIHRPSAASTLTTNSTQS----- 750
            .::.||.:|..                ||.|.  |:||  |.|:::....|.|.|..|.:
pombe   585 NKVVQSDNNVK----------------GGTLPALVHYLVQNVHLNKDFRHSFLLTYKTFTTPQEL 633

  Fly   751 --------HLLPDYPDHVLKVY----KADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSL 803
                    |.||. |......|    |.|.     .:.|:... .|:.|.:|::...|..:..:|
pombe   634 FTLLVILFHELPP-PGLDATAYSSWEKGDN-----FVTKKNVC-TVMNLWVQKYFFEDLKARNTL 691

  Fly   804 CEVS-----VGD--------GGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALE 855
            ..:|     :.|        |.::.     .::.||.               :.||  ||.|...
pombe   692 YLISEMRTFLRDHVVPSFHIGSVIL-----SEIDNLW---------------TEEP--PDSLTQR 734

  Fly   856 LVRESNVHFLHLNAY-----ELAIQLTLQDFANFRQIESTEYVDELFELR-SRYGVPMLSKFAEL 914
            |:......|:.||.|     |.|.|:||.:|...:||.|.|::...:..| ||..|.....|:
pombe   735 LLSSPMATFISLNVYAYTPEEFASQMTLLEFDYLKQIPSREWIFRSWVSRDSRSAVRNYINFS-- 797

  Fly   915 VNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEK 979
             |...:|:::.|..:.|...|..::..||:.|..|...:||:::.:|||.|....:.||...::.
pombe   798 -NCFTYWIINCILEKKNTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAPIYRLHAAYKL 861

  Fly   980 LPSKYQRLFNDLQDLMDPSRNMSKYRQLV-SAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDG- 1042
            :.::.....:.|:::::..:|.|.||.|: .|||    |.:||..::..|||||..||...:|.
pombe   862 VKAEDIICLSGLREIVETKKNFSTYRALLRKAEL----PCVPFLGVILSDLTFIDEGNPDVLDSS 922

  Fly  1043 --LINFEKLRMLAKEVRLLTHMCSSPYDLLSILELK 1076
              |::|.|...||..|..:....||.|::.|..:|:
pombe   923 PHLLSFNKRHRLADVVADVCRFQSSSYEMQSNTDLQ 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	15/100 (15%)
		RasGEF	871..1050	CDD:279011	55/183 (30%)
		Rhomboid_SP	1252..>1357	CDD:289371
efc25	NP_596123.1	RasGEF_N	593..700	CDD:279012	27/129 (21%)
efc25	NP_596123.1	RasGEF	755..932	CDD:279011	55/183 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940