DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and ste6

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_588316.1	Gene:	ste6 / 2538724	PomBaseID:	SPCC1442.01	Length:	911	Species:	Schizosaccharomyces pombe

Alignment Length:	304	Identity:	79/304 - (25%)
Similarity:	140/304 - (46%)	Gaps:	43/304 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 VLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQ 824
            :.|:||..:    |.:.....:.|.::.:|... :|.||:..|        ..|::.:.|..:|:
pombe   590 LFKIYKVFE----VFVVPHFASAEELLHSLSHL-LHHPSTKRS--------HKMLEGKELSQELE 641

  Fly   825 NLAERISFAARYYLKLNDSTEPLV-PDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIE 888
            :|:            |::|.:|:: .|||.|.|...           |:|.||.:.:|.:|..|.
pombe   642 DLS------------LHNSPDPIIYKDELVLLLPPR-----------EIAKQLCILEFQSFSHIS 683

  Fly   889 STEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECR 953
            ..:::.::::..:|:.....:....|.|..:.:|...|..|....||..::..||::..:.:|..
pombe   684 RIQFLTKIWDNLNRFSPKEKTSTFYLSNHLVNFVTETIVQEEEPRRRTNVLAYFIQVCDYLRELN 748

  Fly   954 NFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPI 1018
            ||.|:|:|:|.|....:.|||:||..|.||....|..|.:|.:..:|.|.||..:...:|   |.
pombe   749 NFASLFSIISALNSSPIHRLRKTWANLNSKTLASFELLNNLTEARKNFSNYRDCLENCVL---PC 810

  Fly  1019 IPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHM 1062
            :||..:...||||:..||......:|||:|   ..|..|:|..:
pombe   811 VPFLGVYFTDLTFLKTGNKDNFQNMINFDK---RTKVTRILNEI 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	14/80 (18%)
		RasGEF	871..1050	CDD:279011	54/178 (30%)
		Rhomboid_SP	1252..>1357	CDD:289371
ste6	NP_588316.1	SH3	7..55	CDD:214620
		RasGEFN	489..604	CDD:214571	4/17 (24%)
		RasGEF	659..895	CDD:214539	59/210 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940