Protein Alignment PDZ-GEF and RASGEF1A

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: NP_001269791.1
• Gene: RASGEF1A / 221002
• HGNCID: 24246
• Length: 489
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 108/489 - (22%)
• Similarity: 189/489 - (38%)
• Gaps: 124/489 - (25%)

  Fly   684 SSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNST 748
            |||.|.:.||       |..|.:       |...||.|||...:.:.:.|:...|..:.:
Human    17 SSILGPSCSG-------QVQPGM-------GERGGGAGGGSGDLIFQDGHLISGSLEALM----- 62

  Fly   749 QSHLLPD---YPDHVL--------KVY--------KADQTC---------------------KYV 773
             .||:|.   |||...        :|:        :..|.|                     |.|
Human    63 -EHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIV 126

  Fly   774 LIYKETT-------AHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERIS 831
            .:.||.|       ..|..|..|:..     :...:.|:   .:.|.|| :.:....|:|.  :|
Human   127 QLLKEWTEAFPYDFQDEKAMAELKAI-----THRVTQCD---EENGTVK-KAIAQMTQSLL--LS 180

  Fly   832 FAARYYL-KLNDSTEPLVPDELALELVR----ESNVHFLHLNAYELAIQLTLQDFANFRQI---- 887
            .|||..| :|.:...|...|:..:...:    :.::..:..:...||.|||..:......|
Human   181 LAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPED 245

  Fly   888 --ESTEYVDELFELRSRYGVP---MLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIAR 947
              :...::|.|...|.|..:.   .|..:....|.....|.:|:|.......|.::::.||.:||
Human   246 LMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVAR 310

  Fly   948 HCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVS--- 1009
            .|....|||||.||:||:....|:||::||.|:.:   ..|:.|:..||||.|...||..:.
Human   311 ECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKT---AKFDVLEHHMDPSSNFCNYRTALQGAT 372

  Fly  1010 -----AELLAQHPIIPFYPIVKKDLTFIH-LGNDTRVDGLINFEKLRMLAKEV------------ 1056
                 |....:..:||.:.:..||:.|:| :..:...:|.|||:|...:::::
Human   373 QRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECP 437

  Fly  1057 -----RLLTHMCSSPY---DLLSILELKGQSPSN 1082
                 ::.:::.::|.   :.|.:...:.:.|.|
Human   438 FEKDKKIQSYLLTAPIYSEEALFVASFESEGPEN 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237
		RA_PDZ-GEF1	759..841	CDD:340483	22/126 (17%)
		RasGEF	871..1050	CDD:459872	57/196 (29%)
RASGEF1A	NP_001269791.1	REM	57..184	CDD:100121	26/143 (18%)
		RasGEF	225..419	CDD:459872	57/196 (29%)