DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and Rgl2

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_033085.2	Gene:	Rgl2 / 19732	MGIID:	107483	Length:	778	Species:	Mus musculus

Alignment Length:	819	Identity:	179/819 - (21%)
Similarity:	279/819 - (34%)	Gaps:	241/819 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 TVSGGGRLYQSQSNPDLTSLNYDGGSDAGGN--GGGRLQVNYLNAHIHRPSAAS----------- 741
            |...||.:..|     ..|.:.:.|.|.||.  |||:.:.:      .....||
Mouse    12 TTPPGGVVLSS-----FRSRDPEEGGDPGGRAVGGGQEEED------EEEEEASVSVWDEEEDGA 65

  Fly   742 TLTTNSTQ-------SHLLPDYPDHVLKVYKADQTCKYVLIYKETTA-----------HEVVMLT 788
            |.|..|.|       :.|.|......|:....:...:::|..:...|           |.....|
Mouse    66 TFTVTSRQYRPLDPLAPLPPPRSSRRLRAGTLEALVRHLLDARTAGADMMFTPALLATHRAFTST 130

  Fly   789 LQEFGI----------HDPSSNFSLCEVSVG-----------DGGMVKQRRLPDQLQNLAERISF 832
            ...||:          |.|........|::.           |.|...:.:| |:|::...|..:
Mouse   131 PALFGLVADRLEALESHPPGELERTTGVAISVLSTWLASHPEDFGSEVKGQL-DRLESFLLRTGY 194

  Fly   833 AAR---------YYLKLNDSTEPLVPD---ELALE----------LVRESNVHFLHLNAYELAIQ 875
            |||         ....|....:|..||   .|||.          ||      ||   |..||.|
Mouse   195 AAREGVVGGSADLIRNLRARVDPRAPDLPKPLALPGDSPADPTDVLV------FL---ADHLAEQ 250

  Fly   876 LTLQDFANFRQIESTEYVDELFELRSRYG----VPMLSKFAELVNREMFWVVSEICAEHNI---- 932
            |||.|...|..:..::.:..|:..|.|.|    .|.:.......|:....|||.:....:|
Mouse   251 LTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSIGEGP 315

  Fly   933 ----VR------RMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRL 987
                ||      |.::::::|::|..|:..|||:|::|:||.|....:.|||..|.:......|:
Mouse   316 REVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGETTRDSLRV 380

  Fly   988 FNDLQDLMDPSRNMSKYRQLVSAELLAQHP-----------------IIPFYPIVKKDLTFIHLG 1035
            |:.|..:.....|.|:.|:|:..|:..|.|                 ::|:.....|||..:...
Mouse   381 FSSLCQIFSEEDNYSQSRELLMQEVKPQPPVEPHSKKAPRSGFRGGGVVPYLGTFLKDLVMLDAA 445

  Fly  1036 N-DTRVDGLINFEKLRMLAKEVRLLTHM------CSSPYDLLSILELKGQSPSNALFSLNQMSAS 1093
            : |...:|.|||:|.|   ||..:|:.:      |.. |||....:::     ..|..|..::.:
Mouse   446 SKDELENGYINFDKRR---KEFAILSELLRLQKECRG-YDLRPNSDIQ-----QWLQGLQPLTEA 501

  Fly  1094 QSNAAAGTVIAANAGQATIKRRKK-------------STAAPNPKKMFEE------------AQM 1133
            ||:..:..|.......:...|..:             |...|.|...::.            |.:
Mouse   502 QSHRVSCEVEPPGTSDSPAARTPRPTLVITQWTEVLGSVGGPTPLVSWDRPSVGGDEVPGTPAPL 566

  Fly  1134 VRRVKAYL-----NSL-KILSDEDLLHKFSLECEPAH---------------GSTYSGSISHGNT 1177
            :.|:..::     :|| ..|.....||.   ..:|.|               .|...||...|||
Mouse   567 LTRLAQHMKWPSVSSLDSALESSPSLHS---PADPGHLSPPASSPRPSRGHRRSASCGSPLSGNT 628

  Fly  1178 SHRSGGGGSISGGAGGSSGGGGGGSS-------SLNAGDQLSIYSH---TSSSSAPN-SSLSLRK 1231
                |.|.|.|.|.||  |..|.|||       .:..|:..|:|..   ||...||: .|..|:|
Mouse   629 ----GEGTSRSAGCGG--GVSGPGSSDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISRVLKK 687

  Fly  1232 RHPSSPTLSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKMLSLSESSKI------RPHQPFV 1290
            .:..|...|                     :|.........:.|::..|:.:      ..|. |:
Mouse   688 NNRDSAVAS---------------------EFELVQLLPGDRELTIPHSANVFYAMDGASHD-FL 730

  Fly  1291 PRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSA 1329
            .|.....:...|..|...:|.| :.||.||..:.|...|
Mouse   731 LRQRRRPSAATPGSHSGPSASG-TPPSEGGGGSFPRIKA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	19/124 (15%)
		RasGEF	871..1050	CDD:279011	56/214 (26%)
		Rhomboid_SP	1252..>1357	CDD:289371	16/84 (19%)
Rgl2	NP_033085.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		14/57 (25%)
		RasGEFN	90..212	CDD:214571	19/122 (16%)
		RasGEF	239..513	CDD:214539	74/291 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..524		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..564		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..647		22/74 (30%)
		RalGDS_RA	649..734	CDD:176351	18/106 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..769		10/35 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810