DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and Ralgds

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	XP_006497859.1	Gene:	Ralgds / 19730	MGIID:	107485	Length:	908	Species:	Mus musculus

Alignment Length:	501	Identity:	111/501 - (22%)
Similarity:	172/501 - (34%)	Gaps:	144/501 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   838 LKLNDSTEPLVPDELALEL----------------VRESNV----HFLHLNAYELAIQLTLQDFA 882
            |.|....||.|...|.||.                ..|:.:    |.|......:|.|.||.|..
Mouse   330 LALAPELEPAVSQSLELESAPVPTPALEPSWSLPEATENGLTEKPHLLLFPPDLVAEQFTLMDAE 394

  Fly   883 NFRQIESTEYVDELFELRSRYG----VPMLSKFAELVNREMFWVVSEICAEHNIVR--RMKIVKQ 941
            .|:::.....:..::..|.:.|    .|.:.......|.....|::....:.::..  |.::|:.
Mouse   395 LFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKAPDRARVVEH 459

  Fly   942 FIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQ 1006
            :|::||.|:..:||:|::||:|.|...|:.||::|||::.....|:|..|.::.....|.|..|:
Mouse   460 WIEVARECRALKNFSSLYAILSALQSNAIHRLKKTWEEVSRDSFRVFQKLSEIFSDENNYSLSRE 524

  Fly  1007 LVSAE------LLAQHP---------------IIPFYPIVKKDLTFIHLG-NDTRVDGLINFEKL 1049
            |:..|      .|..:|               .:|:......||..:... .|.....||||||.
Mouse   525 LLIKEGTSKFATLEMNPRRAQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR 589

  Fly  1050 RM---LAKEVRLLTHMCSS-----------------------PYDLLSILELKGQSPSNALFSLN 1088
            |.   :..:::||...|::                       .|.|...||...:|.||.|
Mouse   590 RKEFEVIAQIKLLQSACNNYSIAPEEHFGTWFRAMERLSEAESYTLSCELEPPSESASNTL---- 650

  Fly  1089 QMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLL 1153
                                     |.|||||            :|:|..........||.....
Mouse   651 -------------------------RSKKSTA------------IVKRWSDRQAPSTELSTSSSA 678

  Fly  1154 HKFS---LECEPAHGSTYSGSISHGNTSHRSGGGGSISGGAGGSSGGGGGGSSSLNA-------- 1207
            |..|   |.|.|..|   ||.|:...:.|              |:|........:|.
Mouse   679 HSKSCDQLRCSPYLG---SGDITDALSVH--------------SAGSSSSDVEEINMSFVPESPD 726

  Fly  1208 GDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQR 1253
            |.:...:...|.||...|.:|......||.:.||| ..|:|..|:|
Mouse   727 GQEKKFWESASQSSPETSGISSASSSTSSSSASTT-PVSTTRTHKR 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	1/2 (50%)
		RasGEF	871..1050	CDD:279011	50/206 (24%)
		Rhomboid_SP	1252..>1357	CDD:289371	1/2 (50%)
Ralgds	XP_006497859.1	RasGEFN	112..249	CDD:214571
		RasGEF	376..643	CDD:214539	59/266 (22%)
		RA_RalGDS	792..877	CDD:340729
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810