DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and Rasgrf2

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_036013814.1 Gene:Rasgrf2 / 19418 MGIID:109137 Length:1190 Species:Mus musculus


Alignment Length:1279 Identity:234/1279 - (18%)
Similarity:421/1279 - (32%) Gaps:427/1279 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 LEAEEIDLSGLVESVVDSDEEDLAESMDSLTVRDAVRDCLEKDPAERSEEDVEV-----LLEFTQ 124
            :|.|:|..:.|...:.|.|.| :......:...:..::.:......:.|||.::     :..|.:
Mouse   154 VETEKIATNQLRHQLEDQDTE-IERLKSEIVALNKTKERMRPYHVHQEEEDPDIKKIKKVQSFMR 217

  Fly   125 GLKAFTNITLAVRRALCS----------VMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEH- 178
            |..........|:..:||          .:||       |:|.::.|.:....:|:||.:.... 
Mouse   218 GWLCRRKWKTIVQDYICSPHAESMRKRNQIVF-------TMVEAETEYVHQLYILVNGFLRPLRM 275

  Fly   179 -ANGSREELQMGDSFGI------LPTMDKLYHRGVMRTKCD-------DCQFVCITQTDYYRIQH 229
             |:..:..:...|...|      :..:.:::|:|:.....:       |...:.:...:.|    
Mouse   276 AASSKKPPINHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIY---- 336

  Fly   230 QGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQ 294
              :|..|.|:    :.:.|.                       |:....|..       ::||:|
Mouse   337 --QEFVRNHQ----YSLQVL-----------------------ANCKQNRDF-------DKLLKQ 365

  Fly   295 LVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNN 359
             .|.|...:...:|.| ||:.:| |.|:.:.:       |.::.||...|..:|           
Mouse   366 -YEANPACEGRMLETF-LTYPMF-QIPRYIIT-------LHELLAHTPHEHVER----------- 409

  Fly   360 HFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGG 424
                     :.:||        .:.||....|::|...:....:|        ::..:...||.|
Mouse   410 ---------KSLEF--------AKSKLEELSRVMHDEVSDTENIR--------KNLAIERMIVEG 449

  Fly   425 YELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHL 489
            .:   :.:.|..       :.:..||..|...::|| ::.:|...||. :..:...:....|.|.
Mouse   450 CD---ILLDTSQ-------TFIRQGSLIQVPSVERG-KLSKVRLGSLS-LKKEGERQCFLFTKHF 502

  Fly   490 SISVKSNLLGFKEIMQALEHGGGTA-----------GSGSISAGSG------SFKSVRSPRRI-- 535
            .|..:|:  |.|  :..|:.||..:           ||.....|||      .||.|..|...  
Mouse   503 LICTRSS--GGK--LHLLKTGGVLSLIQCTLIEEPDGSDDDPKGSGHMFGHLDFKIVVEPPDAAS 563

  Fly   536 ----------------------CANDI-------------------------AKLHGRSDSTTDE 553
                                  |.::|                         |:||  .|.|...
Mouse   564 FTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLH--KDDTDIC 626

  Fly   554 LSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSS------AK 612
            .|....|.:...:|.:||:.||::          ::....::.:|:...|.:....:      ||
Mouse   627 FSKTLNSCKVPQIRYASVERLLER----------LTDLRFLSIDFLNTFLHTYRIFTTATVVLAK 681

  Fly   613 KSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTLL-----NDPKSKL 672
            .|         |......|..|.|.|:...|     ..||:...|.|.....|     :.|...:
Mouse   682 LS---------DIYKRPFTSIPVRSLELFFA-----TSQNNREHLVDGKSPRLCRKFSSPPPLAV 732

  Fly   673 SAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRP 737
            |..||...:.:.|:.....|..|.|       |||:.:                           
Mouse   733 SRTSSPVRARKLSLTSSLNSRIGAL-------DLTNSS--------------------------- 763

  Fly   738 SAASTLTTNSTQSHLLPDYPDHVLKVYKADQ-------------TCKYVLIYKE------TTAHE 783
            |::|..||..:.:...|.:...||:...||:             |....|.|::      .:||.
Mouse   764 SSSSPTTTTHSPAASPPPHTAAVLESAPADKAGDSADMSPCRSPTTPRHLRYRQPGGQVADSAHC 828

  Fly   784 VVMLTLQEFGIHDPSSNFSLCEVSVGDG---GMVKQRRLPDQL---QNLAERISFAARYYL---- 838
            .|          .|:|.|::...:.|.|   |...:|....:.   :....|:....|:::    
Mouse   829 SV----------SPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHA 883

  Fly   839 ---KLNDSTE--------------PLVPDE--------LALELVRESNVH--------------- 863
               :||:..:              .|:|.|        .||....:.::|               
Mouse   884 QDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKA 948

  Fly   864 --FLHLNAYELAIQLTLQDFANFRQIESTEYVDE-LFELRSRYGVPMLSKFAELVNREMFWVVSE 925
              |..|:|.|||.|:||.|...||.|...|::.: ..:|......|.:.|.::..|.....|.|:
Mouse   949 ECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQ 1013

  Fly   926 ICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFND 990
            |....:|..|...:::::.:|..|:...|:|.:..|.|.|...|:.||::||.|:..:.:.|.:.
Mouse  1014 IMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDK 1078

  Fly   991 LQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLG--NDTRVDGLINFEKLRMLA 1053
            ||..:.........|:.:..   ...|.:|:..:...||.||..|  |.|. :||:||.|:||::
Mouse  1079 LQKTVSSEGRFKNLRETLKN---CNPPAVPYLGMYLTDLAFIEEGTPNFTE-EGLVNFSKMRMIS 1139

  Fly  1054 KEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKS 1118
            ..:|.:.....:.|.:       .|.|                                      
Mouse  1140 HIIREIRQFQQTAYRI-------DQQP-------------------------------------- 1159

  Fly  1119 TAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEP 1162
                             :|..||....::.|||.|::.||:.||
Mouse  1160 -----------------KVIQYLLDKALVIDEDSLYELSLKIEP 1186

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 19/133 (14%)
RasGEFN 279..400 CDD:214571 24/120 (20%)
PDZ_signaling 404..494 CDD:238492 16/89 (18%)
DegQ <422..494 CDD:223343 14/71 (20%)
PDZ_GEF_RA 757..841 CDD:176380 19/115 (17%)
RasGEF 871..1050 CDD:279011 51/181 (28%)
Rhomboid_SP 1252..>1357 CDD:289371
Rasgrf2XP_036013814.1 PH_RasGRF1_2 19..158 CDD:270081 1/3 (33%)
RhoGEF 247..428 CDD:214619 43/265 (16%)
PH 480..588 CDD:214574 22/112 (20%)
RasGEF_N 638..>686 CDD:395493 11/66 (17%)
REM <853..925 CDD:413353 9/71 (13%)
RasGEF 951..1187 CDD:214539 71/302 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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