DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and Y34B4A.4

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_001024958.1	Gene:	Y34B4A.4 / 180798	WormBaseID:	WBGene00021320	Length:	877	Species:	Caenorhabditis elegans

Alignment Length:	893	Identity:	167/893 - (18%)
Similarity:	295/893 - (33%)	Gaps:	350/893 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 RKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVE 447
            ::.::|.||::.         :.|.|.:......:.|.:.          ..|..:.....||.:
Worm    47 KRSIISLLRIID---------KKCFLNQDVDVNQIKFSLQ----------EVGKLSTKYPKSHQK 92

  Fly   448 PGSKAQDVGLKRGDQIHEV------NGQSLDHVTSKRALEILTGTT------------HLSISVK 494
            ||:   :|.:|...:..|:      :.:::|::.::..|:.:...:            ...|:.|
Worm    93 PGN---EVKVKTNAEFREIETVPNPDEENIDNLLNQLNLKKVPSFSPAFPDIGDDSDDENGITTK 154

  Fly   495 SNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSA 559
            .     ||..:|.:||                      :::|..::.||....:....:..:|:.
Worm   155 Q-----KEEERAEQHG----------------------QKVCEEEVVKLPDGREIRMKKTKTVNV 192

  Fly   560 SNRAHMVRLS--SVDMLLDQPDCAPPQTPPVS---------------------GSGNMA-----S 596
            ......|.:|  |.:|            |.||                     ||.||.     .
Worm   193 KQTTKHVTISTKSANM------------PEVSRTFMNARRGFDEDEEEENTNFGSSNMRGGDPFE 245

  Fly   597 NFMQQL------LQSVNNSSAKKSG--GNSN---------------SDQQDTKGGFMTLAPKRRL 638
            .|...|      ::::...|:...|  |:|:               |::::..|..:......:|
Worm   246 RFRSMLKDKDEKIEAIEGESSSDPGTPGSSSKSKTIERTSEVSQKVSEKKEKDGRLLAEHEASKL 310

  Fly   639 QKALAKMNLLNKQ---NHGSSLND-------SSDTLLNDPKSKLSAVSS---------------- 677
            .|:    ||..||   ..|::|.|       ...||:.....:.|.|::
Worm   311 DKS----NLFAKQVDTYQGAALIDRKGEGSYEESTLVRSALPQDSQVATPPRMHVVEYMMMFGDD 371

  Fly   678 CSSSTQSSINGCTVSGGGRLYQ-----------------SQSNPDLTSLNYDGGSDAGGNGGGRL 725
            ..::....:.|.|:|...||..                 |.:....|:::.|..||.
Worm   372 KKNNENEYLKGTTISSYVRLNNNLTTHEEQFKKKIQFEFSTAGTSSTTIDLDNLSDL-------- 428

  Fly   726 QVNYLNAHIHRP----------------------------------------------------- 737
             :|..:.:..||
Worm   429 -LNQTDFNCLRPPNKFLEDTPLIVEQPKAIDWQREPTSAPPEKDLLLEHDGVDYVIFREKEGKVL 492

  Fly   738 -------SAASTLTTNSTQSHLLPDYPDHVLKVYK---------------------ADQT----- 769
                   .|.....|.||.|.||  |.:..|..::                     ||.:
Worm   493 EVRGGPKDALIVYATQSTHSSLL--YQEAFLITFRTFISSLELVNKLIKRYLYMSLADDSQSESI 555

  Fly   770 -----CKYVLIYKETTAHEV---VMLTLQEFG---IHDPSSNFSLCEVSVGDGGMVKQRRLPDQL 823
                 ...|.|..|||.:|:   ::.::..|.   |||.:..:|          .:.:.||.|::
Worm   556 ARHTFSVIVRIIDETTQYELDFDLITSVTSFVYRLIHDGNFTYS----------RILRTRLLDRI 610

  Fly   824 QNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIE 888
            ::     ||..:..|..| ..:|..|.:|            ....:.|:|.|||..|...:.:||
Worm   611 KD-----SFDIQTVLGTN-LCKPRKPHDL------------FDFKSAEIACQLTFIDSQLYHRIE 657

  Fly   889 STE---YVDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCK 950
            |.|   :..|..|.:|:    .|..|.|..|...|||.:.|..:.....|.:.:.:|:||.:|.:
Worm   658 SAELLWWAQEQNEKKSK----NLVNFTEQFNNLSFWVRTLIITQGTQKERERHMMKFVKIMKHLR 718

  Fly   951 ECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQD-------LMDPSRNMSKYRQLV 1008
            |..||||..||:|.:....::||.  |.|          :::|       :||.:::...||.|:
Worm   719 EMCNFNSYLAILSAIMSTPLARLE--WSK----------NIKDALKEHTAVMDTAQSYKNYRALL 771

  Fly  1009 SAELLAQHPIIPFYPIVKKDLTFIHLGN-DT----RVDG---LINFEK 1048
            ..   |:.|.:|:..|:.:||||:|.|| ||    |..|   :|||.|
Worm   772 QT---AKPPCVPYIGIILQDLTFVHAGNPDTIPSDRCHGAKNMINFLK 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571	3/16 (19%)
		PDZ_signaling	404..494	CDD:238492	14/107 (13%)
		DegQ	<422..494	CDD:223343	11/89 (12%)
		PDZ_GEF_RA	757..841	CDD:176380	20/120 (17%)
		RasGEF	871..1050	CDD:279011	63/196 (32%)
		Rhomboid_SP	1252..>1357	CDD:289371
Y34B4A.4	NP_001024958.1	REM	499..612	CDD:100121	25/124 (20%)
Y34B4A.4	NP_001024958.1	RasGEF	640..818	CDD:279011	63/196 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940