DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and sos-1

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_001360576.1	Gene:	sos-1 / 178846	WormBaseID:	WBGene00004947	Length:	1493	Species:	Caenorhabditis elegans

Alignment Length:	680	Identity:	147/680 - (21%)
Similarity:	249/680 - (36%)	Gaps:	138/680 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   841 NDSTEPLVPDELALELVRESNV-HF--LHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSR 902
            |:|  |...:::.....::.:| |:  |.|:..|:..||||.....:|.|:..|.|:..:....:
Worm   869 NES--PKETNQVLWHTAQKGDVDHYDLLTLHPIEIGRQLTLLHSDLYRAIQPIELVEAAWTKAEK 931

  Fly   903 Y-GVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLG 966
            : ..|.|.:..:......:||...|....::..||.:..:.:::....:|..||..:.|..|.|.
Worm   932 WRKSPQLLRLTDHSTLLTYWVSRSIVETESLEERMAMFNRVLEVMSVFEELHNFTGLVAFYSALN 996

  Fly   967 HGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTF 1031
            ...:.||:..|:.|.::.::.|:....|.:  |...:.::.:|:   ...|.|||:.....::.|
Worm   997 SSCIFRLKWCWDGLDNEKKKCFDRFNTLCE--RRWQEMQKRLSS---INPPCIPFFGHYLSNIYF 1056

  Fly  1032 IHLGNDTRVD-----GLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMS 1091
            :..||.|.|:     |....:|.:   |:                  :||...|.|:.....|:.
Worm  1057 LEQGNSTFVNKSPPHGAAGAQKQQ---KD------------------DLKASDPENSNKQFKQLV 1100

  Fly  1092 ASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDL---L 1153
            :.........||  ...|....:|...|..|..::.||........|         |:|||   |
Worm  1101 SFLKLRKISNVI--REIQIFQDQRYSLTLEPTIRQFFESINPKNDFK---------SNEDLEEYL 1154

  Fly  1154 HKFSLECEPAHGSTYSGSI--SHGNTSHRSGGGGSISGGAGGSSGGGGGGSSSLNAGDQLSIYSH 1216
            :..|||.:|....|.:..:  .|..::.||         .|.......|...|.|....|.::|.
Worm  1155 YNKSLEIQPKGLDTPTAELKPKHNASTLRS---------PGVKPPKAAGNHYSANHPIGLHLHSQ 1210

  Fly  1217 TSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQ-----------RRQMHNNGPKFGTASPQA 1270
             :|.|||::..|.....|::| ||...:..|.|.:|           |.:.....||.....|..
Worm  1211 -NSHSAPHAMSSQSSTVPNTP-LSAHETKRSLSHNQDDAPLQQFVDIRFERKGTHPKIPVLQPPP 1273

  Fly  1271 VKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVV---TSPATSAVAN 1332
            :....|.:..|......|       |....:||           .|...|::   |||.|
Worm  1274 LLPRSSRANQSNSVSLPP-------TTQAPMPP-----------APKSSGMMSTATSPTT----- 1315

  Fly  1333 VQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTPAPP----PPLPSVDLSLESS-------SV 1386
            :..|.:||       ::||   |...:|.|..:..|..|    |..||.|.|..|:       ..
Worm  1316 LTTTTTPS-------SAGG---PPPKLHPRRMTQQPMSPLAKSPLTPSRDNSSPSAFQFPVVYEA 1370

  Fly  1387 TTFRDLPLRKSV---------TSGSISSCDSGYVHQQQHYHLQYQQQQQQNSSQHEPS--PPVYT 1440
            :|...||.|.|.         ||||.||...   ..|:...:.:.:.|::.:..:.||  .|..:
Worm  1371 STAPPLPPRPSTSSDVSSSPSTSGSTSSATK---ENQEQLRVIFDRFQRRITFSNRPSFCAPSTS 1432

  Fly  1441 AADCRLLQQISNNAVTRNLNSPC--QSTNT 1468
            ::....:.::.....|.....|.  |.:||
Worm  1433 SSSTERIFRVPGATTTSTKIKPSQQQQSNT 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	147/680 (22%)
		RasGEF	871..1050	CDD:279011	41/184 (22%)
		Rhomboid_SP	1252..>1357	CDD:289371	23/118 (19%)
sos-1	NP_001360576.1	RhoGEF	248..447	CDD:383033
		PH-like	493..604	CDD:388408
		RasGEF_N	659..794	CDD:366199
		RasGEF	900..1069	CDD:366198	39/173 (23%)
		Neogenin_C	1148..1377	CDD:368988	63/272 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940