Protein Alignment PDZ-GEF and Rasgrp4

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: XP_038939950.1
• Gene: Rasgrp4 / 170668
• RGDID: 620476
• Length: 726
• Species: Rattus norvegicus
• Alignment Length: 810
• Identity: 170/810 - (20%)
• Similarity: 273/810 - (33%)
• Gaps: 202/810 - (24%)

  Fly   613 KSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTLLNDPKSKLSAVSS 677
            |:||:....|...   ..|....|.:.|.:|.:|                         |..:|.
  Rat    65 KAGGHGRPRQARR---HKTCPTPREISKVMASLN-------------------------LGVLSE 101

  Fly   678 CSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGG-NGGGRLQVNYLNAHIHRPSAAS 741
            .|.|....:..|.     |.:.|                ||. :.|..:....|..|      :.
  Rat   102 SSCSVDELLEECI-----RCFDS----------------AGSLHRGDHILKMVLTMH------SW 139

  Fly   742 TLTTNSTQSHLLPDYPDHV--LKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLC 804
            .|.::...:.||..|....  .:..:..|.| |::.|..|...|||.   ||..:....:.|
  Rat   140 VLPSSDLAARLLTSYQKAAKDARELRQLQIC-YLVRYWLTHHPEVVH---QEPQLEAIINRF--- 197

  Fly   805 EVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNA 869
            ..:|...|.:.||.|.|            |...|.......|.:.....|...|:.::.|.||..
  Rat   198 WTTVAQEGNMAQRSLGD------------ASNLLSPGGPGPPPLMSSPGLGKKRKVSLLFDHLET 250

  Fly   870 YELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVR 934
            .|||..||..:|.:|:.|...:....:.:...| |.|.|.....|.|....||...:.:.....:
  Rat   251 EELAQHLTYLEFRSFQAITPQDLRGYVLQGSVR-GCPALEGSVGLSNSVSRWVQVMVLSRPGPAQ 314

  Fly   935 RMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSR 999
            |.:::.:||::|:..::.:|||::.|:..||.|.|:|||:.:...|.....:...:|.:|:....
  Rat   315 RAQVLDKFIRVAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHN 379

  Fly  1000 NMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV-DGLINFEKLRMLAKEVRLLTHM- 1062
            |.:.||:..::....:.|::..:   .|||..::..:..|: ||.::..||..|...::.|..:
  Rat   380 NYAYYRRTWASCTDFRLPVLGVH---LKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELAALQ 441

  Fly  1063 -----CSSPYDLLSILELKGQSPSNALF----SLNQMS-ASQSNAAAGTVIAANAGQATIKRRKK 1117
                 ||:..|||.:|.|     |..||    .:.::| |.:........::.......::....
  Rat   442 RQHPPCSANEDLLHLLTL-----SLDLFYTEDEIYELSYAREPRCPKSLPLSPFKAPVVVEWAHG 501

  Fly  1118 STAAPNPKKMFEEA-QMVRRV-KAY----LNSLKILSDEDLLHKFSLECE-----PAHGSTYSGS 1171
            .|..|:...:.:.. |:|..| |.|    ..|:.:...|.|...|...|.     |.||   |||
  Rat   502 VTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLEDFEKLSANFPFACHGLHPPPRHG---SGS 563

  Fly  1172 ISHGNTSHRSGGGGSISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSS 1236
            .|.                                  ::|:.|  ...:||..|.|.|...|
  Rat   564 FSR----------------------------------EELTKY--LLHASAICSKLGLAFLH--- 589

  Fly  1237 PTLSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKMLSLSE---------------SSKIRPH 1286
             .....:....|..|......:.||.:|     ..|:.....:               ..|.||
  Rat   590 -AFQEVTFRKPTFCHSCNGFVSTGPLWG-----VTKRGYRCQDCGLCCHRHCRDQVRVECKKRP- 647

  Fly  1287 QPFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGG 1351
                    .|.....||     .|.|.:||.|     .....:...:..|.||      .|.||.
  Rat   648 --------ETKGDPGPP-----GAPGPATPLP-----PTGCGSEEGLSYTLSP------HLESGC 688

  Fly  1352 NIIPSRAIHERSHSD-----TPAPPPPLPS 1376
            ::..:....|.|||.     .|.|.|.|||
  Rat   689 HLHHAWTQTESSHSSWEPEMVPCPAPVLPS 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237
		RA_PDZ-GEF1	759..841	CDD:340483	19/83 (23%)
		RasGEF	871..1050	CDD:459872	45/179 (25%)
Rasgrp4	XP_038939950.1	REM	105..220	CDD:100121	31/160 (19%)
		RasGEF	245..480	CDD:214539	63/243 (26%)
		C1	586..647	CDD:412127	8/69 (12%)