DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZ-GEF and RASGRP4

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	NP_733749.1	Gene:	RASGRP4 / 115727	HGNCID:	18958	Length:	673	Species:	Homo sapiens

Alignment Length:	442	Identity:	103/442 - (23%)
Similarity:	172/442 - (38%)	Gaps:	83/442 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   681 STQSSINGCTVSGGGR-----LYQSQSNPD-------LTSLNYDGGSDAGGNGGGRLQVNYLNAH 733
            |.:.|...||...|||     :.:.::.|.       :.|:|....|:     ||..:...|...
Human     6 SKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSE-----GGCSEDELLEKC 65

  Fly   734 IHRPSAASTLTTNSTQSHLLPDYPDHVLKVY---------KADQTCKYVLIYKETTAHEVVMLTL 789
            |....:|.:|.           :.||:|.:.         .||...:.:..|::.|.....:..|
Human    66 IQSFDSAGSLC-----------HEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRL 119

  Fly   790 Q-------------EFGIHDPSSNFSLCEV------SVGDGGMVKQRRLPDQLQNLAERISFAAR 835
            |             |....||    .|.||      :|...|...||||.|....|:.
Human   120 QICHLVRYWLMRHPEVMHQDP----QLEEVIGRFWATVAREGNSAQRRLGDSSDLLSP------- 173

  Fly   836 YYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELR 900
                 .....||......|...|:.::.|.||...|||..||..:|.:|:.|...:....:.:..
Human   174 -----GGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGS 233

  Fly   901 SRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGL 965
            .| |.|.|.....|.|....||...:.:....::|.:::.:||.:|:...:.:|||::.|:..||
Human   234 VR-GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGL 297

  Fly   966 GHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLT 1030
            .|.|:|||:.:...|.....:...:|.:|:....|.::||:..:.....:.|::..:   .|||.
Human   298 CHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVH---LKDLV 359

  Fly  1031 FIHLGNDTRV-DGLINFEKLRMLAKEVRLLTHM------CSSPYDLLSILEL 1075
            .:|.....|: ||.::..||..|...::.|..:      ||:..|||.:|.|
Human   360 SLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380	23/111 (21%)
		RasGEF	871..1050	CDD:279011	46/179 (26%)
		Rhomboid_SP	1252..>1357	CDD:289371
RASGRP4	NP_733749.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		7/23 (30%)
		REM	57..164	CDD:100121	23/121 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..187		8/38 (21%)
		RasGEF	197..432	CDD:214539	59/219 (27%)
		C1	541..590	CDD:197519
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..621
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910