DRSC/TRiP Functional Genomics Resources

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Protein Alignment PDZ-GEF and Rapgef1

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_006497645.1 Gene:Rapgef1 / 107746 MGIID:104580 Length:1257 Species:Mus musculus


Alignment Length:614 Identity:150/614 - (24%)
Similarity:239/614 - (38%) Gaps:138/614 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   489 LSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDE 553
            ||:||.::.|.        .||         |....|:|||   .|..:.|....|   .::...
Mouse   662 LSVSVSNSFLN--------RHG---------SLPVPSYKSV---FRSYSQDFMPHH---QASVQP 703

  Fly   554 LSSVSASNRAHM--VRLS-SVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQ-----SVNNSS 610
            ....::|:..|.  |..| |.|:.:......||.|.....|.:..|:|....::     |..:||
Mouse   704 FLPPTSSSSPHFPPVHTSQSSDLAVPTVSSPPPSTVDGPLSSSQDSSFHGNPVRLPSETSFTDSS 768

  Fly   611 AKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMN---LLNKQNH-------GSSLNDSSDTLL 665
            .|.|...:..|:      :::|....:..:.||...   ...|..|       .:|..||.:...
Mouse   769 EKASSEEAGGDE------YVSLYSSGQTSEELAPCRGEPPSGKDGHPRDPSVSSASGKDSRENGE 827

  Fly   666 NDPKSKLSAVSSCSSSTQ----SSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQ 726
            ..||| |..:.|..|..:    |.|:...:.  .||...|..        |.|.|..|..|..|.
Mouse   828 RSPKS-LDGLESAQSEEEVDELSLIDHNEIM--ARLTLKQEG--------DDGPDVRGGSGDILL 881

  Fly   727 VN-----------YLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLK--VYKADQTCKYVLIYKE 778
            |:           |..|.         |||..|...     |:.::|  .|:.::...:...:|:
Mouse   882 VHATETDRKDLVLYCEAF---------LTTYRTFIS-----PEELIKKLQYRYEKFSPFADTFKK 932

  Fly   779 TTAHEVVMLTLQEFGIHDPSSNFSLCE-------------VSVGDGGMVKQRRLPDQLQNLAERI 830
            ..:.....:.::   :.|......|.|             |..|:..:.:..|     :|:.:::
Mouse   933 RVSKNTFFVLVR---VVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLR-----KNILDKV 989

  Fly   831 SFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTE---Y 892
            .  .:..|:...|.:||....:|   .|...:|..|  ::|:|.||||.|...|.:||..|   :
Mouse   990 D--QKKLLRCAHSDQPLAARGVA---ARPGTLHDFH--SHEIAEQLTLLDAELFYKIEIPEVLLW 1047

  Fly   893 VDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNS 957
            ..|..|.:|    |.|::|.|..|...:||.|.|..:.....|.:::.:||||.:|.::..||||
Mouse  1048 AKEQNEEKS----PNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNS 1108

  Fly   958 MFAIVSGLGHGAVSRL---RQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPII 1019
            ..||:|.|....:.||   |||.|.|.        :...|:|.|.:...||..:|.   .:.|.|
Mouse  1109 YLAILSALDSAPIRRLEWQRQTSEGLA--------EYCTLIDSSSSFRAYRAALSE---VEPPCI 1162

  Fly  1020 PFYPIVKKDLTFIHLGNDTRVDGLINFEK 1048
            |:..::.:||||:||||...:||.:||.|
Mouse  1163 PYLGLILQDLTFVHLGNPDYIDGKVNFSK 1191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999
RasGEFN 279..400 CDD:214571
PDZ_signaling 404..494 CDD:238492 3/4 (75%)
DegQ <422..494 CDD:223343 3/4 (75%)
PDZ_GEF_RA 757..841 CDD:176380 12/98 (12%)
RasGEF 871..1050 CDD:279011 66/184 (36%)
Rhomboid_SP 1252..>1357 CDD:289371
Rapgef1XP_006497645.1 PHA03247 <227..337 CDD:223021
PHA03307 678..>878 CDD:223039 48/222 (22%)
RasGEFN 868..1009 CDD:214571 27/164 (16%)
RasGEF 1016..1245 CDD:214539 68/193 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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