DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and RAPGEF3

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_011536054.1 Gene:RAPGEF3 / 10411 HGNCID:16629 Length:938 Species:Homo sapiens


Alignment Length:1116 Identity:264/1116 - (23%)
Similarity:405/1116 - (36%) Gaps:427/1116 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 EEDLAESMDSLTVR--DAVRD-CLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMV 145
            ||:|||::..|:.|  ||:.. .|.|.|.:|::|:::::.|....:||..:::.:|:|.|.:|::
Human   213 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLL 277

  Fly   146 FAVVDKAGTVVMSDGEELDSWSVLINGAVE-IEHANGSREELQMGDSFGILPTMDKLYHRGVMRT 209
            |....|||||:.|.|::..||.::..|:|. :.|..|....|..||.||.|..::.......:..
Human   278 FEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIIL 342

  Fly   210 KCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASAS 274
            :.|:|.|:.:.:.|:.||....|..|.|.| |:|.||:|.| |:..|||.....:.|        
Human   343 REDNCHFLRVDKQDFNRIIKDVEAKTMRLE-EHGKVVLVLE-RASQGAGPSRPPTPG-------- 397

  Fly   275 LNMKRGHVVIRGTPERLLQQLVE----ENSMTDP--TYVEDFLLTHRIFIQNPQEVTSKLLHWFD 333
               :..:.|:.||||::|:.|:|    ::|..||  |::.|||||||:|:.:.| :.:.|||.|.
Human   398 ---RNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQ-LCAALLHHFH 458

  Fly   334 LEQVDAHKTQ------ELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQL-- 390
            :|.....:.:      ..|.::.|:|..||..:.:....|.....||:....|:.|...||.|  
Human   459 VEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLR 523

  Fly   391 ---------RLLHIAC---AAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYI 443
                     ..|...|   :.:.:.|:..:...::||||                          
Human   524 EQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPL-------------------------- 562

  Fly   444 SHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALE 508
                |||..   .::.||::                                             
Human   563 ----PGSSC---AIQVGDKV--------------------------------------------- 575

  Fly   509 HGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDM 573
                                   |..||..|.:.|       |.:| .|:||.|..|..|:    
Human   576 -----------------------PYDICRPDHSVL-------TLQL-PVTASVREVMAALA---- 605

  Fly   574 LLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQD--TKGGFMTLAPKR 636
                                                            |:|  |||         
Human   606 ------------------------------------------------QEDGWTKG--------- 613

  Fly   637 RLQKALAKMNLLNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQ 701
               :.|.|:|                                             |.|       
Human   614 ---QVLVKVN---------------------------------------------SAG------- 623

  Fly   702 SNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKA 766
                          ||.|     ||          |.|....|:......|....|..|      
Human   624 --------------DAIG-----LQ----------PDARGVATSLGLNERLFVVNPQEV------ 653

  Fly   767 DQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERIS 831
                           ||::           |.                     ||||        
Human   654 ---------------HELI-----------PH---------------------PDQL-------- 663

  Fly   832 FAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQD---FANFRQIESTEYV 893
                         .|.|.....|:||          :|.:||.|||..|   |.:..|:|...||
Human   664 -------------GPTVGSAEGLDLV----------SAKDLAGQLTDHDWSLFNSIHQVELIHYV 705

  Fly   894 DELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSM 958
            .....||. .....|.:|....|...:||.:|:|.......|.:::::|||:|.|.||.:|.||.
Human   706 LGPQHLRD-VTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSF 769

  Fly   959 FAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYP 1023
            ||::.||.:.|:|||..|||:||.|.::|::.|:.|:|||.|...|| |..|:|  ..|:|||.|
Human   770 FAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYR-LALAKL--SPPVIPFMP 831

  Fly  1024 IVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHMCSS--PYDLLSILELKGQSPSNALFS 1086
            ::.||:||||.||.|.|:.||||||:||:|:..|:| |.|.|  |..|         ||..    
Human   832 LLLKDMTFIHEGNHTLVENLINFEKMRMMARAARML-HHCRSHNPVPL---------SPLR---- 882

  Fly  1087 LNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDED 1151
             :::|....::....:       :|...:..||.:|            ....||:..||::.::.
Human   883 -SRVSHLHEDSQVARI-------STCSEQSLSTRSP------------ASTWAYVQQLKVIDNQR 927

  Fly  1152 LLHKFSLECEP 1162
            .|.:.|.|.||
Human   928 ELSRLSRELEP 938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 33/109 (30%)
RasGEFN 279..400 CDD:214571 41/146 (28%)
PDZ_signaling 404..494 CDD:238492 10/89 (11%)
DegQ <422..494 CDD:223343 5/71 (7%)
PDZ_GEF_RA 757..841 CDD:176380 9/83 (11%)
RasGEF 871..1050 CDD:279011 78/181 (43%)
Rhomboid_SP 1252..>1357 CDD:289371
RAPGEF3XP_011536054.1 DEP_Epac 100..238 CDD:239884 10/24 (42%)
CAP_ED 262..371 CDD:237999 32/108 (30%)
Crp 283..>361 CDD:223736 24/77 (31%)
REM 407..526 CDD:100121 37/119 (31%)
RasGEF 673..905 CDD:238087 96/267 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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