DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and rapgef3

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_005162410.1 Gene:rapgef3 / 101886094 ZFINID:ZDB-GENE-090312-38 Length:885 Species:Danio rerio


Alignment Length:1159 Identity:252/1159 - (21%)
Similarity:406/1159 - (35%) Gaps:444/1159 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 HQKCNRGSHSSDTSSAYSGSDTMASNYASSLEAEEIDLSGLVESVVDSDEEDLAESMDSLTVR-- 97
            |.|.....|..||            .:...:|| |.||:..... .||.:::|.||: ||.::  
Zfish   138 HVKQELNFHDKDT------------QFYRFMEA-EFDLNHTTNE-KDSKDDELQESL-SLLIQMG 187

  Fly    98 -DAVRD-CLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDG 160
             ||:.. .|.|.|::|:.||:||:.|....:||..:::.:||:.|.||:||....|||||:.|.|
Zfish   188 PDALLTMILRKCPSQRTPEDLEVIYEELLHVKAVAHLSTSVRKELASVLVFESHAKAGTVLFSQG 252

  Fly   161 EELDSWSVLINGAVE-IEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDY 224
            ::..||.::..|:|. |.|..|....|..||.||.|..::.......:..:.|:|.|:.:.:.|:
Zfish   253 DKGTSWYIIWRGSVNVITHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 317

  Fly   225 YRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPE 289
            .||....|.||.|.| |:|.||:|.|               .|:...:.|.|.   :.|:.||||
Zfish   318 IRILKDVEANTVRLE-EHGKVVLVLE---------------KSSAQDTPSCNK---YTVMSGTPE 363

  Fly   290 RLLQQLVEENSM-------TDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRD 347
            ::|:.::|...:       .||. |.||||||.:|:.                            
Zfish   364 KILEHMLEAIKLETNGADFIDPC-VTDFLLTHPVFMP---------------------------- 399

  Fly   348 RVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSS 412
                                                   .|||      |||        |....
Zfish   400 ---------------------------------------CSQL------CAA--------LQHHY 411

  Fly   413 RDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSK 477
            :.||..     |.:|...|.|..                                       |.:
Zfish   412 QAEPSE-----GSDLEKAAYALN---------------------------------------TKQ 432

  Fly   478 RALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAK 542
            :.:::                                                    :|      
Zfish   433 KVVKL----------------------------------------------------VC------ 439

  Fly   543 LHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVN 607
                                 |.|.|.:: :|.|.|               :||.|:::..:.|.
Zfish   440 ---------------------HWVALFAL-LLRDDP---------------VASEFLEKFREGVM 467

  Fly   608 NSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTLLNDPKSKL 672
            ..|...|                                :|.:|     |.|...|.:.:     
Zfish   468 ADSRLSS--------------------------------MLREQ-----LRDRRKTKIME----- 490

  Fly   673 SAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRP 737
                          |||..              ||.||.              :.::.:|:   .
Zfish   491 --------------NGCHT--------------LTKLNQ--------------KFDWFSAY---E 510

  Fly   738 SAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFS 802
            .....|.:...|..:|       .:::|.|.....|::..:.:.::::...:      ||..|:.
Zfish   511 EPVGKLRSIKAQDKVL-------YEIFKPDHKAVTVMLPVDASVNDILTTLV------DPDRNYV 562

  Fly   803 LCEV-SVGDGGMVKQRRLPDQLQNLAERISFAA--RYYLKLNDSTEPLVPDELALELVRESNVHF 864
            |.:: |.||       |:..:|:..|...|...  :.:|..:...|.|.||:..|...:.:....
Zfish   563 LVKMNSSGD-------RVQLKLETTAVSASLGVNEKLFLCTSSQVEQLTPDKEQLGPEKSTMDTL 620

  Fly   865 LHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYG--VPMLSKFAELVNREMFWVVSEIC 927
            ..:.:.::|.|.|..|:..|..:...|.|..:|......|  ...|.:|....|...:|||:|:|
Zfish   621 EQICSKDMASQHTSYDWELFMAMHEVELVYYVFGREKFPGSTTANLERFVRRFNEVQYWVVTELC 685

  Fly   928 AEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQ 992
            ...::.:|..::|:|||:|...||.:|.||.||::.||.:.||.||.:|||:||:|.:|::...:
Zfish   686 LCEDLGKRAILLKKFIKMAVVLKEQKNLNSFFAVMFGLSNSAVQRLNKTWERLPNKTKRIYCAYE 750

  Fly   993 DLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVR 1057
            .|||||||...|| |..|:|  ..|.|||.|::.||:||||.||....|.|:||||:||:|:.|:
Zfish   751 RLMDPSRNHRAYR-LTIAKL--SPPYIPFMPLLLKDMTFIHEGNKNYTDKLVNFEKMRMIARTVK 812

  Fly  1058 LLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAP 1122
            .:....|.||        ...||...|                                      
Zfish   813 TVRDCRSQPY--------VPSSPQKGL-------------------------------------- 831

  Fly  1123 NPKKMFEEAQMVR---------------RVKAYLNSLKILSDEDLLHKFSLECE 1161
             .::||.:||.:|               .::.|:.:||::.::..|.:.|...|
Zfish   832 -TERMFLDAQAIRISTYSDQSLNLRSATSIRQYIQNLKVIDNQKKLTQLSRALE 884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 37/109 (34%)
RasGEFN 279..400 CDD:214571 22/127 (17%)
PDZ_signaling 404..494 CDD:238492 8/89 (9%)
DegQ <422..494 CDD:223343 5/71 (7%)
PDZ_GEF_RA 757..841 CDD:176380 15/86 (17%)
RasGEF 871..1050 CDD:279011 74/180 (41%)
Rhomboid_SP 1252..>1357 CDD:289371
rapgef3XP_005162410.1 DEP_Epac 71..198 CDD:239884 20/74 (27%)
CAP_ED 222..331 CDD:237999 36/108 (33%)
Crp 241..>321 CDD:223736 25/79 (32%)
RasGEFN 353..485 CDD:214571 49/392 (13%)
RasGEF 620..884 CDD:214539 94/313 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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