Protein Alignment PDZ-GEF and rapgef4

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: XP_031749210.1
• Gene: rapgef4 / 100497690
• XenbaseID: XB-GENE-6048644
• Length: 1033
• Species: Xenopus tropicalis
• Alignment Length: 1022
• Identity: 231/1022 - (22%)
• Similarity: 358/1022 - (35%)
• Gaps: 384/1022 - (37%)

  Fly    77 ESVVDSDEEDLAESMDSLTVRDAV------RDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLA 135
            |...:|||    |..|:|.:...:      |..|.|.|.:||.:|:|::.|....:||.::::..
 Frog   325 EEKKESDE----ELQDTLLLLSQIGPDAHMRMILRKPPGQRSADDLEIIFEELIHIKALSHLSTT 385

  Fly   136 VRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIE-HANGSREELQMGDSFGILPTMD 199
            |:|.|...::|....|||||:.:.|||..||.:::.|:|.:. :..|....|..||.||.|..::
 Frog   386 VKRELAGFLIFESHPKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVN 450

  Fly   200 KLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGS 264
            .......:..:.|:|.|:.:.:.|:.||....|.||.|.::.:..|:::.::         .|||
 Frog   451 DAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKI---------LAGS 506

  Fly   265 GGSATGASASLNMKRGHVVIRGTPERLLQQLVEE-------NSMTDPTYVEDFLLTHRIFIQNPQ 322
            .|||.|.:.|   ...:.|:.|.||:||:..:|.       |..|| |.::||:|.|.:|:.|.|
 Frog   507 QGSAQGNTQS---PYKYTVMSGNPEKLLEHFLETMRLDPSLNDATD-TALDDFILMHCVFMPNSQ 567

  Fly   323 EVTSKLLHWF-----DLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLE 382
            ...:.:.|:.     ..||.....|...:.||.|:|..|...:......|...|.|||.|
 Frog   568 LCPALMSHYHAQPSQGTEQEKLDYTLNNKRRVIRLVQQWATLYGDLLREDEVSMAFLEEF----- 627

  Fly   383 RKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVE 447
                       :::.:...|.                                .||:...:..:|
 Frog   628 -----------YVSVSDDTRT--------------------------------TAALKEQLPDLE 649

  Fly   448 PGSKAQDVGLKRGDQIHE-VNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGG 511
            ...|          ||.| ..||...|
 Frog   650 RAIK----------QISEDAKGQQKKH-------------------------------------- 666

  Fly   512 GTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLD 576
                                          |:..|..||.||
 Frog   667 ------------------------------KVLLRQFSTGDE----------------------- 678

  Fly   577 QPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKA 641
                                                                        ||||.
 Frog   679 ------------------------------------------------------------RLQKR 683

  Fly   642 LAKMNLLNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDL 706
            .|..              |||.||
 Frog   684 QAIR--------------SSDELL----------------------------------------- 693

  Fly   707 TSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCK 771
                                                                  .|||..|.|..
 Frog   694 ------------------------------------------------------FKVYCIDHTYT 704

  Fly   772 YVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGG---MVKQRRLPDQLQNLAERISFA 833
            .:.:....:..||:.....:.|..|     ||..|.:...|   ::|    |::: ::...:|..
 Frog   705 TIRVAVAASVKEVLSAVADKLGSGD-----SLILVKISSAGEKVVLK----PNEI-SVFTTLSVN 759

  Fly   834 ARYYLKLNDSTEPLVPDELALELVRESNVH------FLHLNAYELAIQLTLQDFANFRQIESTEY 892
            .|.:....|..:.|.|      |..:....      |..:::.:||.|:|:.|:..|..:...|.
 Frog   760 GRLFACPRDQFDSLTP------LPEQEGPSAGTMSTFELMSSKDLAYQMTIHDWDLFSCVHELEL 818

  Fly   893 VDELFELRS-RYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFN 956
            :...|..:: :.....|..|....|...||||:|||....:.:|::::|:|||||.||||.:|.|
 Frog   819 IYHTFGRQNFKKTTANLDLFLRRFNEIQFWVVTEICLCPQLSKRVQLLKKFIKIAAHCKEYKNLN 883

  Fly   957 SMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPF 1021
            |.||||.||.:.|||||..||||||||:::::.:.::|||||||...|| |..|:|  ..|||||
 Frog   884 SFFAIVMGLSNVAVSRLSLTWEKLPSKFKKIYAEFENLMDPSRNHRAYR-LTVAKL--DPPIIPF 945

  Fly  1022 YPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYD 1068
            .|::.||:||.|.||.|.:|.|:||||:||:|..:|.:.:..|.|::
 Frog   946 TPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTLRTIRYCRSVPFN 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999	33/109 (30%)
		RasGEFN	279..400	CDD:214571	33/132 (25%)
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237	10/92 (11%)
		RA_PDZ-GEF1	759..841	CDD:340483	17/84 (20%)
		RasGEF	871..1050	CDD:459872	83/179 (46%)
rapgef4	XP_031749210.1	CAP_ED	43..158	CDD:237999
		DEP_Epac	228..356	CDD:239884	9/34 (26%)
		CAP_ED	378..489	CDD:237999	33/110 (30%)
		RasGEF_N	521..627	CDD:459873	32/106 (30%)
		RasGEF	790..1031	CDD:214539	90/206 (44%)