Protein Alignment PDZ-GEF and rgl2

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: XP_002938730.3
• Gene: rgl2 / 100489210
• XenbaseID: XB-GENE-494220
• Length: 701
• Species: Xenopus tropicalis
• Alignment Length: 610
• Identity: 124/610 - (20%)
• Similarity: 212/610 - (34%)
• Gaps: 198/610 - (32%)

  Fly   865 LHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVP-----MLSKFAELVNREMFWVVS 924
            |...|..:|.|||..:.:.|.::...|.:..::..|.:.|.|     .:.:..:..|| :...|:
 Frog   197 LAFQAGHVAEQLTSMEASLFLRVVPYECLGSVWSRRDKVGSPWNRCQSVRETVQHFNR-LSGAVT 260

  Fly   925 EICAEHNIVR---RMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQR 986
            ..|.....::   |.:|:::::::|..|:..|||:|::||::.|...||.||::.|.:...:..|
 Frog   261 SACVRDPQLKPQQRARIIEKWVRVAEECRSLRNFSSVYAIITALQSTAVHRLKKVWAETSREILR 325

  Fly   987 LFNDLQDLMDPSRNMSKYRQLV-----------------SAELLAQHPIIPFYPIVKKDLTFIHL 1034
            .:.:::::.....|.::.|:|:                 :.|..|...::|:..:...||..:..
 Frog   326 SYQEMREVFCEKDNYARMRELLFQPHDQPEITSKRQQPRTRESRAVQGVVPYLGVFLTDLVMLDS 390

  Fly  1035 G-NDTRVDGLINFEKLRM---LAKEVRLLTHMC------SSPYDLLSILELKGQSPSNALFSLNQ 1089
            . .|...:|.:||||.|.   ...::|:|..:|      |.|..:.....|:..|.:.:.    |
 Frog   391 AIRDQLENGYLNFEKRRKEFEALSQIRILQSVCQGYRFHSDPQFITWFQRLQPISEAESY----Q 451

  Fly  1090 MSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLH 1154
            :|. .......||..:|              .|.||                  :.|....|||
 Frog   452 LSC-DIEPTQDTVTTSN--------------PPKPK------------------VVITHCTDLL- 482

  Fly  1155 KFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSS 1219
                                          .:|:...|.|                    .|..|
 Frog   483 ------------------------------AAIAAPFGPS--------------------MHVVS 497

  Fly  1220 SSAPNS-----SLSLRKRHPSSPTLSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKMLSLSE 1279
            ...|..     |||..::.||.|.|.|.||                ||.      .:|.:|:||.
 Frog   498 WDTPCDRQMALSLSPHQKSPSVPALDTQSS----------------PKL------PMKGLLALSP 540

  Fly  1280 SSKIRPHQPFVPRHGSTMAGVI-------PPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTP 1337
            .:  |.|     |..::....|       |.|.|. |.|.    ||.|   |.|...:..|:..|
 Frog   541 VA--RTH-----RRSASCGSAINASAEPHPSLDHT-AEHS----SPTG---SNAEHRIIRVRVEP 590

  Fly  1338 SPSPCSHR--RLAS--GGNIIPSRAIHERSHSDTPAPP---------------PPLPSVDLSLES 1383
            :.....::  |::|  ....:..|.:  |.|..||..|               |...:|..::.|
 Frog   591 AEENSVYKSVRISSQEKAPAVIDRIL--RKHHMTPQGPQELIQLLPEGKELVIPEKANVFYAMSS 653

  Fly  1384 SSVTTFRDLPLRKSVTSGSISSCDS 1408
            :|:    |..||...|..|.||.|:
 Frog   654 ASL----DFLLRPRKTVSSASSTDT 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237
		RA_PDZ-GEF1	759..841	CDD:340483
		RasGEF	871..1050	CDD:459872	44/204 (22%)
rgl2	XP_002938730.3	RasGEF_N	61..160	CDD:459873
		RasGEF	196..455	CDD:238087	56/263 (21%)
		Ubl1_cv_Nsp3_N-like	579..663	CDD:475130	18/89 (20%)