DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and rasgrf2

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_002942408.2 Gene:rasgrf2 / 100486502 XenbaseID:XB-GENE-483993 Length:1232 Species:Xenopus tropicalis


Alignment Length:1324 Identity:252/1324 - (19%)
Similarity:436/1324 - (32%) Gaps:424/1324 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 HSSDTSSAYSGSDTMASNY---ASSLEAEEIDLSGLVESVVDSDEEDLAESMDSLTVRDAVRDCL 104
            |.:..|......:.:...|   ...:|.|:|..:.|.:.:.|.|.|  .|.:.|..|  |:....
 Frog   125 HQASYSDVLIEREVLMQKYIHLVQIVETEKIAANQLRQQLEDQDTE--IERLKSEIV--ALNKTK 185

  Fly   105 EK-DPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSV 168
            |: .|.:.::||.:      ..:|....:...:|..||.                     ..|..
 Frog   186 ERMRPYQMNQEDED------PDIKKIKKVQSFMRGWLCR---------------------RKWKT 223

  Fly   169 LINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKC------------------DDCQ 215
            ::...:...||...|:..|:  .|.::....:..|:..:...|                  ||..
 Frog   224 IVQDYICSPHAESMRKRNQI--VFNMVEAEAEYVHQLYILVNCFLRPLRMAASSKKPPISHDDVS 286

  Fly   216 FVCI---TQTDYYRIQHQG---------------------------EENTRRHEDENGFVVMVTE 250
            .:.:   |....:.|.|||                           :|..|.|:    :.:.|. 
 Frog   287 SIFLNSETIMFLHEIFHQGLKARINNWPTLILADLFDILLPMLNIYQEFVRNHQ----YSLQVL- 346

  Fly   251 LRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHR 315
                                  |:....|..       ::||:| .|.|...:...:|.| ||:.
 Frog   347 ----------------------ANCKQNRDF-------DKLLKQ-YETNPACEGRMLETF-LTYP 380

  Fly   316 IFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDR------------VTRVVLLWVNNHFTDFE--- 365
            :| |.|:.:.:       |.::.||...|..:|            ::||    :::..:|.|   
 Frog   381 MF-QIPRYIIT-------LHELLAHTPHEHVERKSLDFAQSKLEELSRV----MHDEVSDTENIR 433

  Fly   366 --ADYEMMEFLEVFEALLE------RKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNF--- 419
              ...|.| .:|..:.||:      |:..|.|:..:.....:|.|:...:|.|....:...|   
 Frog   434 KNLSIERM-IVEGCDILLDTSQTFVRQGTLIQVPSVERGKLSKVRLGPLSLKREGERQCFLFTKH 497

  Fly   420 -----RIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRA 479
                 |..|| :|.  .:.||.....|..:.:|.....:|.  .:|      .|....|:..|..
 Frog   498 FLICTRSSGG-KLH--LLKTGGVLSLIECTLIEEPDLGEDD--TKG------TGYVFGHLDFKIV 551

  Fly   480 LEILTGTTH----LSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDI 540
            :|.:...:.    |:.|.:.......:|.|.:|:   ...:|.:|........|..|..|.::  
 Frog   552 IEPVDSPSFTVVLLAPSRQEKAAWTSDISQCVEN---IRCNGLMSNVFEENSKVTVPHMIRSD-- 611

  Fly   541 AKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQS 605
            |:||  .|......|....|.:...:|.:|||.||::          ::....::.:|:...|.:
 Frog   612 ARLH--KDDVDICFSRTLNSCKVPQIRYASVDRLLER----------LTDLRFLSIDFLNTFLHT 664

  Fly   606 VNNSSAKKSGGNSNSDQQDTKGGFMTL-------------APKRRLQKALAKMNLLN--KQNH-- 653
            ....:|                .|:.|             .|.|.|:...|....|:  |..|  
 Frog   665 YRIFTA----------------AFVVLEKLADIYKRPFTSIPVRSLELFFATSQNLSDGKSPHLC 713

  Fly   654 -------GSSLNDSSDTL------LNDP-KSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNP 704
                   ..||:.:|..:      ||.| .|::.|:...:||:.||...        ::...::|
 Frog   714 RKFSSPPPLSLSRTSSPIRARKLSLNSPLNSRIGALDLSTSSSASSPTS--------VFSPATSP 770

  Fly   705 -------------DLTSLNYDGGSDAGGNGGGRLQV-NYLNAHIHR-------------PSAAST 742
                         .|:|.....||....:...|:.: |.|...|.|             |.::.:
 Frog   771 PPTTAKVPLDLSKGLSSPEQSPGSIDENSENPRIDLCNKLRRSIRRAAVLESVSLDRTIPESSQS 835

  Fly   743 LTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIH-DPSSNFSLCEV 806
            ..|........|..|.|              |.|:.|.    |..:..:.|.. .|:|.|::...
 Frog   836 TDTAENSPCRSPSTPRH--------------LRYRPTG----VQASDNQRGCSVSPASAFAIATA 882

  Fly   807 SVGDG---GMVKQRRLPDQ------------LQNLAERIS-----FAARYYLKLNDST------- 844
            ..|.|   |.....|:.|:            |..|...:|     |...:.:|:|...       
 Frog   883 GAGHGSPPGFNNMERICDKEFIIRRAATNRVLNVLRHWVSKHAQDFELNHEIKMNVVNLLEDVLR 947

  Fly   845 EP-LVPDE--------LALELVRESNVHFL-----------------HLNAYELAIQLTLQDFAN 883
            :| |:|.|        .||....:.:.|.:                 .|:|.|||.|:||.|...
 Frog   948 DPDLLPQERKAATNILSALSQEEQDDCHLVLEDIINMSESPSSECLETLSAMELAEQITLLDHIV 1012

  Fly   884 FRQIESTEYVDELF---ELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKI 945
            ||.|...|::.:.:   :...|  .|.:.|.::..|.....|.|||....::..|...:::::.:
 Frog  1013 FRSIPYQEFLGQGWMKPDKSER--TPYIMKTSQHFNDMSNLVASEIMKHPDVPSRASSIEKWVVV 1075

  Fly   946 ARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSA 1010
            |..|:...|:|.:..|.|.|...||.||::||.|:..:.:.|.:.||..:.........|:.:..
 Frog  1076 ADICRCMHNYNGVLEITSALNRSAVYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKN 1140

  Fly  1011 ELLAQHPIIPFYPIVKKDLTFIHLG--NDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSIL 1073
               ...|.:|:..:...||.||..|  |.|. :||:||.|:||::..:|.:.....:||      
 Frog  1141 ---CNPPSVPYLGMYLTDLAFIEEGTPNFTE-EGLVNFSKMRMISHIIREIRQFQQTPY------ 1195

  Fly  1074 ELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVK 1138
                                                 .|:.:.|.|                  :
 Frog  1196 -------------------------------------RIEHQPKVT------------------Q 1205

  Fly  1139 AYLNSLKILSDEDLLHKFSLECEP 1162
            ..||..:|| |||.|::.||..||
 Frog  1206 FLLNKSRIL-DEDNLYELSLRIEP 1228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 19/156 (12%)
RasGEFN 279..400 CDD:214571 30/143 (21%)
PDZ_signaling 404..494 CDD:238492 19/101 (19%)
DegQ <422..494 CDD:223343 15/75 (20%)
PDZ_GEF_RA 757..841 CDD:176380 20/104 (19%)
RasGEF 871..1050 CDD:279011 52/183 (28%)
Rhomboid_SP 1252..>1357 CDD:289371
rasgrf2XP_002942408.2 PH_RasGRF1_2 19..154 CDD:270081 4/28 (14%)
RhoGEF 243..424 CDD:214619 35/230 (15%)
PH 488..582 CDD:365918 18/104 (17%)
RasGEF_N 634..>682 CDD:366199 11/73 (15%)
REM <896..967 CDD:383003 13/70 (19%)
RasGEF 993..1229 CDD:214539 74/304 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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