Protein Alignment PDZ-GEF and rgl3a

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: XP_073809706.1
• Gene: rgl3a / 100149956
• ZFINID: ZDB-GENE-101130-1
• Length: 785
• Species: Danio rerio
• Alignment Length: 738
• Identity: 160/738 - (21%)
• Similarity: 253/738 - (34%)
• Gaps: 248/738 - (33%)

  Fly   701 QSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLL------PDYPDH 759
            |..||.|.      |||   ..|.:|  |....:.|..||   |.:...:.|:      |||...
Zfish    82 QPPPDATE------SDA---AFGFMQ--YRTLKVRRLKAA---TLDRLVTELVNPECPDPDYMHI 132

  Fly   760 VLKVYKADQTCKYVLI-----------------YKETTAHEVVMLTLQEF--GIHDPSSNFSLCE 805
            .|..|:| .||...||                 ..:::...::.|.|.||  .:.|...:.:|..
Zfish   133 FLSTYRA-FTCTNALIELLFQREDMVTNLNNSVCVKSSLPRLIRLWLDEFHEDLRDSPDHQALRL 196

  Fly   806 VSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTE--------PLVPDELALELVRESNV 862
            :.|.....:..|||.:|...|..:.....:   ::..|.|        |...|.|..:.|:|..
Zfish   197 LCVHLRHRLCCRRLVNQADALLRKFQTEDK---QICTSAEVSASAVENPATEDNLDGQEVQEIG- 257

  Fly   863 HFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEIC 927
            ..|...|.::|.|||:.|...|.::.....:..::..|.:           ..|:.:...|....
Zfish   258 DVLDFPAQDIAEQLTILDAELFSKVVPFHCLGCIWSQRDK-----------KENQNLVSTVRATI 311

  Fly   928 AEHNIVR----------------------------RMKIVKQFIKIARHCKECRNFNSMFAIVSG 964
            |:.|:|.                            |.||::::|.:|:.|.:.|||:|:.||:|.
Zfish   312 AQFNVVTNCVITSLLCPPATSPPGSPPCHRSSPTYRAKIIEKWISVAQECHQLRNFSSLRAILSA 376

  Fly   965 LGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQH------------- 1016
            |...||.||::||..:..:...:|..|.|.. |..|.    .|::.|:|.:.
Zfish   377 LQSNAVYRLKKTWAVISRESMAVFEHLCDTF-PDENC----VLINREILVEEGNQAADVETYSAP 436

  Fly  1017 ------PI-----------IPFYPIVKKDLTFIHLGNDTRVD-GLINFEKLRMLAKEVRLLTHMC 1063
                  |.           :|:.......||.:.......|: |||||||.|   ||
Zfish   437 KSPRLSPTCKHMQSSSSGEVPYLGTYLTVLTMLDTALTDNVEGGLINFEKRR---KE-------- 490

  Fly  1064 SSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMF 1128
               :::||:              :.|:.||.::                     .|...:|
Zfish   491 ---FEILSL--------------IRQLQASCAH---------------------YTLQSHP---- 513

  Fly  1129 EEAQMVRRVKAYLNSLKILSDE---DLLHKFSLECEPAHGSTYSGS-----------ISHGNTSH 1179
                   |:.:::||...|||:   :|..:.....:|...|..|.|           :|......
Zfish   514 -------RIISWINSSMSLSDQKSYELSRELEPPVDPCPSSPNSWSHRLIAKKLNLLLSATENFS 571

  Fly  1180 RSGGGGSISGGAGGSSGGG----GGGSSSLNAG-------------DQLSIYSHTSSSSAPNS-S 1226
            |......||..:.||||..    |...||.|..             ..:|:.:.|||.:.|.| .
Zfish   572 RKTLADQISVSSSGSSGSDMEDLGRDLSSPNLSPLVYKVWSPSVSCQDISVDTPTSSPTPPPSCQ 636

  Fly  1227 LSLRKRHPSSP-TLSTTSSTSSTSDHQRRQMH--------------------NNGPKFGTASPQA 1270
            .||:...|.|| :.|::||:||.|.|||..:|                    |||        ..
Zfish   637 RSLQADLPESPSSTSSSSSSSSPSLHQRCALHPMYNKQVADSCIVRVSVEFGNNG--------NV 693

  Fly  1271 VKKMLSLSESSKIRPHQPFVPRH 1293
            .|.:|..|:....:..|..:.:|
Zfish   694 YKSILITSQDKTAQVVQRALEKH 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237
		RA_PDZ-GEF1	759..841	CDD:340483	19/100 (19%)
		RasGEF	871..1050	CDD:459872	52/237 (22%)
rgl3a	XP_073809706.1	None