DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and rapgef2

DIOPT Version :10

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_012811943.1 Gene:rapgef2 / 100145659 XenbaseID:XB-GENE-5814345 Length:1661 Species:Xenopus tropicalis


Alignment Length:1604 Identity:585/1604 - (36%)
Similarity:813/1604 - (50%) Gaps:326/1604 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LHQKCNR--GSHSSDTSSAYSGSDTMASNY-ASSLEAEEIDLSGLVESVVDS----DEEDLAESM 91
            ||.:...  .|||..:.::.|||.:::..| |:..|..::|||||.|:.|||    ||||:..:.
 Frog   195 LHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEPGDMDLSGLPETAVDSEDDDDEEDIERAS 259

  Fly    92 DSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVV 156
            |.|..||.|||||||||.:|:::|:|.||||...|.||.|:|::|||.||:|||||||::|||||
 Frog   260 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVV 324

  Fly   157 MSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQ 221
            ::||||||||||::||:||:.:.:|..|.|.||:|||:.|||:|.|.:||||||.||||||||.|
 Frog   325 LNDGEELDSWSVILNGSVEVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQ 389

  Fly   222 TDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRG 286
            .||.||.:|.|:|.::.|:| |.:|||.|.|.:...||                  ::||:||:|
 Frog   390 QDYCRILNQVEKNMQKVEEE-GEIVMVKEHRELDRTGT------------------RKGHIVIKG 435

  Fly   287 TPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTR 351
            |.|||...||||:|:.||||:||||||:|.|:.:|.||..|||.||:        ...|||:|||
 Frog   436 TSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFN--------DPSLRDKVTR 492

  Fly   352 VVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEP 416
            ||||||||||.|||.|..|..|||.||..|||:|:...||||:|||||||:.|..|||:.||:.|
 Frog   493 VVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLITLTKPSREAP 557

  Fly   417 LNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALE 481
            |.|.::||          .:...||::..|:|||||.:.||||||||.|||||:.:::...:|||
 Frog   558 LPFNLLGG----------SDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALE 612

  Fly   482 ILTGTTHLSISVKSNLLGFKEIM-QALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHG 545
            ||...||||::||:||..|||:: :.||.                 |...:|......||.|   
 Frog   613 ILRNNTHLSLTVKTNLFVFKELLARMLEE-----------------KRNSAPHLPKIGDIKK--- 657

  Fly   546 RSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSS 610
                         ||      |.|..|:.:|                         :.|.:....
 Frog   658 -------------AS------RYSIPDLAVD-------------------------VEQVIGLEK 678

  Fly   611 AKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMN---LLNKQNHGSSLNDSSDTLLNDPKSKL 672
            ..|.|      :.:|.||      :.:|:|.|.|..   |..|..:...:..|.|          
 Frog   679 VSKKG------KANTVGG------RNKLKKILDKTRISILPQKPYNDIGIGQSQD---------- 721

  Fly   673 SAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRP 737
               .|.....|:.....|:...|.|  |.|||||                       |.:| || 
 Frog   722 ---DSIVGLRQTKHMPATLPVSGTL--SSSNPDL-----------------------LQSH-HR- 756

  Fly   738 SAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFS 802
                .|..|:|     |:.||.||:|:||||..:|::|.|:|||.|||:..::||.:......:|
 Frog   757 ----ILDFNTT-----PEQPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTAVPDAYS 812

  Fly   803 LCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHL 867
            ||||||...|::|||||||||..||:||..:.|||||.|..||.|..||.|.:|:|||.:..|.|
 Frog   813 LCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQL 877

  Fly   868 NAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNI 932
            :..|:|.||::::|..||.||.|||:|:||:|:.:.|...|..|.|::|:|.|||.|||..|.|.
 Frog   878 STIEVATQLSMRNFELFRNIEPTEYIDDLFKLKMKTGCTNLKNFEEVINQETFWVASEILRETNQ 942

  Fly   933 VRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDP 997
            ::||||:|.|||||.||:||:||||||||:|||....|||||.|||||||||::||.|||||.||
 Frog   943 LKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDP 1007

  Fly   998 SRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHM 1062
            ||||:|||.:::::.| |.||||.:|::||||||:|.|||::||||:|||||||:|||:|.:..|
 Frog  1008 SRNMAKYRNVLNSQNL-QPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRM 1071

  Fly  1063 CSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTV--IAANAGQATIKRRKKSTAAPNPK 1125
            .|...|    ..|..::......||..:|...:||   ||  :|.:.|.   |:|.:.::..|.|
 Frog  1072 ASVNMD----PALMFRTRKKKWRSLGSLSQGSTNA---TVLDVAQSGGH---KKRVRRSSFLNAK 1126

  Fly  1126 KMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISGG 1190
            |::|:|||.|:||.||:.|.:..||:.|...|::||||     :.::.......|:|        
 Frog  1127 KLYEDAQMARKVKQYLSDLDLEMDEENLQTLSVQCEPA-----TNTLPKNPCEKRAG-------- 1178

  Fly  1191 AGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQRRQ 1255
                                    ...:|..||.::...:::......::......:.:.:..|:
 Frog  1179 ------------------------KPDTSPVAPRAAAQHKQQQQQQTKVNQALQVPAVALYPSRK 1219

  Fly  1256 M--HNNGPKFGTASPQAVKKMLSLSESSKIRPHQPFV---------------------PRHGSTM 1297
            .  ..:.|.||..||||:||:|||||...:..|:...                     ||.|.||
 Frog  1220 KVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQCSPRKGYTM 1284

  Fly  1298 A--GVIPPLH----------------------HMH----AAHGFSTPSPG-GVVTSPATSAVANV 1333
            |  |.:....                      |:|    ..|..|..... ||..:...:.:...
 Frog  1285 AASGTVDNFSDSGHSEISSRSSIVSNSSFDCVHLHDDRRQRHSLSIVETNLGVGRADRRAIIDAD 1349

  Fly  1334 QCT-PSPSPCSHRR-LASGGNIIPSRAIHERSHSDTPAPPPPLPSVD------LSLESSSVTTFR 1390
            ||: .|.:|.:..| |.:|..::.|.::.|.|...  .....|.:.|      .|..|.|....:
 Frog  1350 QCSLGSYAPVAETRGLYAGATVLSSPSMEELSQDQ--GDRASLDAADSGRGSWTSCSSGSHDNIQ 1412

  Fly  1391 DLPLRKS---------------------VTSGSISSCDSGYVHQQQHYHLQYQQ-----QQQQNS 1429
            .:|.::|                     .|.|.:   |.|........:.:|.|     .|.|:.
 Frog  1413 TIPHQRSWETLPFGHVHFDNTADGSGFWATGGHM---DHGIFPDHSTKYGRYSQGREPLDQAQSR 1474

  Fly  1430 SQHEPSPPVY---TAADCRLLQQISNNAVTRNLNSPCQSTNTPPST-PTPPPNQPTATIQLSAPP 1490
            :....|...:   :..|...:::.....|.....:...::.||..| |.|.|.....|...:...
 Frog  1475 ASWASSTGYWGEDSEGDTGTIKRRGGKDVALEAETSSITSMTPEETKPLPVPTHVAVTASSAKGL 1539

  Fly  1491 TAAAYMHARSQHQQLQQQQQSLAMPPPPPPPYNVPPLGSIYSHH 1534
            .......||.:.:..:        |||.||.|...|:......|
 Frog  1540 IVYCVTTARKEGRYRE--------PPPTPPGYVGIPIADFADGH 1575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 70/108 (65%)
RasGEFN 279..400 CDD:214571 72/120 (60%)
PDZ_RapGEF2_RapGEF6-like 404..496 CDD:467237 43/91 (47%)
RA_PDZ-GEF1 759..841 CDD:340483 44/81 (54%)
RasGEF 871..1050 CDD:459872 110/178 (62%)
rapgef2XP_012811943.1 CAP_ED 37..143 CDD:237999
cNMP 297..412 CDD:197516 72/115 (63%)
RasGEFN 428..541 CDD:214571 72/120 (60%)
PDZ_RapGEF2_RapGEF6-like 545..627 CDD:467237 43/91 (47%)
RA_PDZ-GEF1 769..851 CDD:340483 44/81 (54%)
RasGEF 874..1099 CDD:238087 126/229 (55%)
Blue background indicates that the domain is not in the aligned region.

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