DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and rapgef4b

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_001108368.1 Gene:rapgef4b / 100141331 ZFINID:ZDB-GENE-080219-4 Length:427 Species:Danio rerio


Alignment Length:121 Identity:41/121 - (33%)
Similarity:69/121 - (57%) Gaps:15/121 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 LEAEEIDLSGLVESVVDSD------EEDLAESMDSLTV--RDA-VRDCLEKDPAERSEEDVEVLL 120
            |:.||.|      :|:.||      ||:|.|::..|:.  .|| :|..|.|.|.:|:.||:|::.
Zfish   288 LDDEEED------AVLPSDDEKREAEEELQETLLFLSQIGPDAHMRMILRKPPGQRTAEDLEIIY 346

  Fly   121 EFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEI 176
            :....:||.::::..|:|.|..|::|....|||||:.:.|||..||.::..|:|.:
Zfish   347 DELLHIKAVSHLSNTVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIIQKGSVNV 402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 18/49 (37%)
RasGEFN 279..400 CDD:214571
PDZ_signaling 404..494 CDD:238492
DegQ <422..494 CDD:223343
PDZ_GEF_RA 757..841 CDD:176380
RasGEF 871..1050 CDD:279011
Rhomboid_SP 1252..>1357 CDD:289371
rapgef4bNP_001108368.1 CAP_ED 44..153 CDD:237999
Crp 65..>153 CDD:223736
DEP_Epac 204..332 CDD:239884 16/49 (33%)
CAP_ED 356..>406 CDD:237999 17/47 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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