Protein Alignment PDZ-GEF and ralgds

DIOPT Version :10

• Sequence 1: NP_609012.2
• Gene: PDZ-GEF / 33881
• FlyBaseID: FBgn0265778
• Length: 1573
• Species: Drosophila melanogaster
• Sequence 2: XP_012823402.1
• Gene: ralgds / 100135084
• XenbaseID: XB-GENE-987988
• Length: 856
• Species: Xenopus tropicalis
• Alignment Length: 748
• Identity: 157/748 - (20%)
• Similarity: 263/748 - (35%)
• Gaps: 244/748 - (32%)

  Fly   714 GSDAGGNGGGRLQVNYLNAHIHRPSAAS---TLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLI 775
            |...||..|.|      :..:...|..|   |....|.::..|....::::..:|.:.: .||.|
 Frog   108 GCADGGLAGLR------DTTVENDSGLSLYETCKVRSIKAGTLEKLVEYLVSAFKGNDS-TYVTI 165

  Fly   776 YKET-----TAHEVVMLTLQEFGIHDPSSNFSLCEVSVGD------------GGMVKQ-----RR 818
            :..|     |..:|:.|.|..||...|..|......||.|            |..:.|     |:
 Frog   166 FLCTYRAFATTKQVLDLLLNRFGRLHPQINGEHSHNSVDDRLELKNTISSILGAWLDQYSEDFRQ 230

  Fly   819 LPD-----QL----------QNLAER-ISFAARYYLKLNDSTEPLVPDELA--LELVRE-----S 860
            .||     ||          .:|..| .:...::..:...:.||.|.|..:  |.||.|     .
 Frog   231 APDYTCLKQLITYVRHNIPGSDLERRACNLLTQFKRQQISALEPDVVDHTSCTLRLVEEPLLSDG 295

  Fly   861 NVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPML--------SKFAELVNR 917
            ...||......||.|.|:.|...|:::.....:..::..|.:.|...|        |:|..:.|
 Frog   296 KPDFLSFRQDMLAEQFTVMDAELFKKVVPYHCLGCIWSQRDKKGKEHLAPTIRATVSQFNSVTN- 359

  Fly   918 EMFWVVSEICAEHNI--VRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKL 980
               .|:|....:.::  .:|.|:::::|::||.|:..:||:|:.||:|.|...|:.||::||:::
 Frog   360 ---CVISTCLCDRSLKPQQRAKVIERWIEVARECRILKNFSSLRAILSALQCNAIHRLKKTWDEV 421

  Fly   981 PSKYQRLFNDLQDLMDPSRNMSKYRQLV------------------------SAELLAQHPIIPF 1021
            ..:..|:|.:|.::.....|.|..|:|:                        ..|:......||:
 Frog   422 SRESYRIFMELSEIFSDENNHSLSRELLIKEGTSKFATLDINPKRAQKRQQQQREMGVMQGTIPY 486

  Fly  1022 YPIVKKDLTFIHLG-NDTRVDGLINFEKLRM---LAKEVRLLTHMCSSPYDLL----------SI 1072
            ......||..:... .|....|||||||.|.   :..:::||...|:: |..|          |:
 Frog   487 LGTFLTDLVMLDTAMKDYLESGLINFEKRRKEFEVIAQIKLLQSACNN-YSFLPDESFVEWFHSV 550

  Fly  1073 LELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKR---RKKSTAAPNP-----KKMFE 1129
            ..|......:....:..:|.|.||     .:.|......|||   |:..::.|.|     .|.|:
 Frog   551 ERLTEAESYSLSCEIEPLSESASN-----TLKAKKNTGIIKRWSDRQPPSSEPCPSVSSHSKSFD 610

  Fly  1130 EAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISGGAGGS 1194
            :                           |:|.|                |..||
 Frog   611 Q---------------------------LKCSP----------------HLCGG----------- 621

  Fly  1195 SGGGGGGSSSLNAGDQLSIYSHTSSSS-APNSSLSLRKRHPSSPTLSTTSSTSSTSDHQRRQMHN 1258
                       :..|.||:.|..|||| ....::|.   .|.||            |.|.::: .
 Frog   622 -----------DTTDSLSVTSAGSSSSDVDEINISF---VPESP------------DCQEKKV-R 659

  Fly  1259 NGPKFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGF------STPS 1317
            .||                |::..|:|.:|.||                   .||      |:..
 Frog   660 EGP----------------SQARPIQPAEPCVP-------------------EGFWESTSLSSLD 689

  Fly  1318 PGGVVTSPATSAVANVQCTPSPSPCSHRRLASG 1350
            ..|:.:..::::.::|..||..:..:|:|..||
 Frog   690 TSGIGSGSSSASSSSVSSTPVSASRTHKRSVSG 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	404..496	CDD:467237
		RA_PDZ-GEF1	759..841	CDD:340483	25/119 (21%)
		RasGEF	871..1050	CDD:459872	52/213 (24%)
ralgds	XP_012823402.1	RasGEFN	135..265	CDD:214571	27/130 (21%)
		RasGEF	299..564	CDD:238087	62/269 (23%)
		RA_RalGDS	740..825	CDD:340729