DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and rasgrp1

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_001093748.2 Gene:rasgrp1 / 100101791 XenbaseID:XB-GENE-489811 Length:811 Species:Xenopus tropicalis


Alignment Length:707 Identity:143/707 - (20%)
Similarity:233/707 - (32%) Gaps:231/707 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   785 VMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRL-PDQLQN----LAERISFAARYYL------ 838
            :|||:..|.:  ||:..           ::|.|.| .|.|||    ...||.:..||::      
 Frog   104 IMLTMHGFLL--PSTEL-----------LMKLRTLYQDALQNRSFSFCLRICYFIRYWVTELWVM 155

  Fly   839 -----KLNDSTEPLVP------DELALELV-------------------------RESNVHFLHL 867
                 ||..:.|....      :||...|:                         |:.::.|.||
 Frog   156 FKMDAKLTQAMEEFQELVRSKGEELHWRLIDTAQINSRDWSRKLTQRIKPNCSKKRKVSLLFDHL 220

  Fly   868 NAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGV-------PMLSKFAELVNREMFWVVSE 925
            ...|||..||..:|..||:|..::|        ..|.|       |.:.:...|.|....||...
 Frog   221 EPQELAEHLTYLEFKAFRRISFSDY--------QNYIVSGCVKENPTMERSIALCNGISQWVQLM 277

  Fly   926 ICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFND 990
            :.:......|.:::.:||.:|:...:.:|||::.|::.||.|.::|||:.|...:.....::.|:
 Frog   278 VLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDVNKVLNE 342

  Fly   991 LQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLG-NDTRVDGLINFEKLRMLAK 1054
            :.:|:...||...||::.:.   ..:..||...:..|||..:|.. .|...|..||..||..|..
 Frog   343 MTELLSSCRNYDNYRRVYNE---CTNFKIPILGVHLKDLIALHEAMPDFLEDSKINVPKLHSLYN 404

  Fly  1055 EVRLLTHM------CSSPYDLLSILELKGQ--SPSNALFSLNQMSASQSNAAAGT------VIAA 1105
            .:..|..:      ..:..||:.:|.|...  ...:.::.|:.....:::.|...      |:|.
 Frog   405 HINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPSKPPVVAD 469

  Fly  1106 NAGQATIKRRKKSTAAPNPKKMFEEAQ-MVRRV-KAY-LNSLKILSDED---------------- 1151
            .|...:.|        |:||.:.:..| ||..| |.| |:....:|.|:                
 Frog   470 WASGVSPK--------PDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMD 526

  Fly  1152 -----------------------------LLHKFS-------LECEPAHGSTYSGSISHGNTSHR 1180
                                         .||.|.       ..|:...|..: |.|..|.....
 Frog   527 KDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLW-GVIKQGYRCKD 590

  Fly  1181 SGGG----------------GSISGGAGGS---SG------GGGGGSSSLNAGDQLSIYSHTSSS 1220
            .|..                ..:|.|...|   ||      .||.|.::...|.:...||:    
 Frog   591 CGMNCHKQCKELVVFECKKRSKLSVGENSSMFDSGQLEVIPAGGKGQTNDCLGAEEGPYSY---- 651

  Fly  1221 SAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKMLSLSESSKIRP 1285
              ||....:.              |..:.|.....|.::..|.......|||...:.:|      
 Frog   652 --PNGDGDIH--------------TEVSKDRTIMLMGSSAQKISVRLQPAVKHRATQTE------ 694

  Fly  1286 HQPFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSPSPC 1342
            ::|                    .:.....|||....|...||   ::..:|.||||
 Frog   695 NEP--------------------QSLCLQVPSPQRSRTPGLTS---HLPISPMPSPC 728

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999
RasGEFN 279..400 CDD:214571
PDZ_signaling 404..494 CDD:238492
DegQ <422..494 CDD:223343
PDZ_GEF_RA 757..841 CDD:176380 18/71 (25%)
RasGEF 871..1050 CDD:279011 49/186 (26%)
Rhomboid_SP 1252..>1357 CDD:289371 18/91 (20%)
rasgrp1NP_001093748.2 REM 77..193 CDD:100121 23/101 (23%)
RasGEF 217..453 CDD:214539 60/246 (24%)
EF-hand_7 494..543 CDD:372618 6/48 (13%)
C1_1 558..607 CDD:365894 8/49 (16%)
BRLZ 744..799 CDD:197664
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.