DRSC/TRiP Functional Genomics Resources

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Protein Alignment PDZ-GEF and rapgef5b

DIOPT Version :10

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_001429535.1 Gene:rapgef5b / 100073343 ZFINID:ZDB-GENE-061215-2 Length:873 Species:Danio rerio


Alignment Length:980 Identity:216/980 - (22%)
Similarity:346/980 - (35%) Gaps:333/980 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   305 TYV----EDFLLTHRIFIQNPQEVTSKLLHW---FDLEQVDAHKTQELRDRVTRVVLLWV--NNH 360
            ||:    .::|:.|..|||| :|:.||:  |   .||.                 :||.|  ||.
Zfish   103 TYIGIELVEWLMDHCEFIQN-REIASKI--WNVLLDLG-----------------ILLSVEQNNI 147

  Fly   361 FTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGY 425
            |.|..:.|: ..|.|                     |.|    :||.....     :|:|     
Zfish   148 FEDSRSLYQ-FTFKE---------------------CEA----QSCDFRNQ-----VNWR----- 176

  Fly   426 ELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLS 490
                       :||.:.:..| |..:......:|..:..:....:.:.|...||||      |.:
Zfish   177 -----------SAVHLLLQLV-PHEQLCGGTQRRCKEDKQKTPDACNPVLQMRALE------HFT 223

  Fly   491 ISVKSNLLGF---KEIMQALE------HGGGTAGSGSISA------GSGS-----FKSVRSPRRI 535
            .:|::.||..   |...:::|      |...|.||.|..|      |:|:     ...:...:|:
Zfish   224 STVQNELLAALARKAQTKSMEEDSNPQHNTDTPGSSSTPAVLKQVPGAGTRDREEISRLEMVQRL 288

  Fly   536 CANDIAKLHG----------------RSDSTTDEL--SSVSASNRAHMVRLSSVDMLLDQPDCAP 582
            ..:....||.                |.:...:.|  ::|....|:|.|.|......|..|    
Zfish   289 AKDGCRLLHSPLRVNERPAEFVECICRGEDWDNPLGDAAVRVCERSHEVLLPKRTTSLKSP---- 349

  Fly   583 PQTPPVSGSGNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNL 647
                                              :|:|.....:...:..:|::.|:..|.::.|
Zfish   350 ----------------------------------SSSSSSWSRRYAAVPASPEKVLEHVLGQLRL 380

  Fly   648 LNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYD 712
            ..:|.  |..:..:|:||:|.........|.|...|:.: |...|..||:.:......|..... 
Zfish   381 DEEQK--SLQSRETDSLLDDFLLTYPVFMSTSDLCQALL-GHYCSKKGRMKEEWRESLLRKRKV- 441

  Fly   713 GGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQS-------------HLLPD---YPD--- 758
                                 :|..|..|:|.|...|.             |:|.|   :|.   
Zfish   442 ---------------------LHLLSQWSSLCTELPQDDDNTKLFLKTLYRHVLDDLYEFPPLEK 485

  Fly   759 --------------HVLKVYKADQTCKYVLIYKETTAHEVVMLTLQE--FGIHDPSSNFS--LCE 805
                          |.:..|...:..|.:.       |:   |:|:|  ..:..|.....  ||.
Zfish   486 DLKELQKLLRMQRRHTVDEYSPQRKNKALF-------HQ---LSLKESWHPMRGPERERKEVLCR 540

  Fly   806 VSVGDGGMVKQRR-----LPDQLQNLAER--------------------------------ISFA 833
            |.|.....|..|.     :.:.|:.:|||                                :|.|
Zfish   541 VYVTVDSYVSVRTHSEVCVQELLRAVAERLDCAEDDMVLMALTYPGEKVVLELDQCVFSSSLSAA 605

  Fly   834 ARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFE 898
            .|.::...|.||.:.|   ..:..::.:...|.:|.:::::.||..|::.|..|...|.|.....
Zfish   606 ERLHVFRRDLTEIMSP---FTDNGQQCSGKMLSMNTWDVSVSLTNCDWSLFSNIHEQELVYFTLS 667

  Fly   899 LRSRYG-VPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIV 962
            ..|..| ...|.:..:..|....||::|:.....:.:|:::.|:|||||.|||..||.||:|||:
Zfish   668 RDSSSGHTVALEQLLQRCNETQQWVMTEVLLCSTLCKRVQLFKKFIKIAAHCKAQRNLNSLFAII 732

  Fly   963 SGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKK 1027
            .||...|||||.|||||:|.|:::||::|:.|.|||.|...||   .|....:.|.|||.|::.|
Zfish   733 LGLNSPAVSRLTQTWEKVPGKFRKLFSELESLTDPSLNHKAYR---DAFRKMKSPKIPFLPLLLK 794

  Fly  1028 DLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSA 1092
            |:||||.||.|.:|.|:||:||.|:|..||:: ..|.:.:            ..|.||..:.|  
Zfish   795 DITFIHEGNKTFLDNLVNFDKLHMIADTVRII-RQCRTDH------------MGNLLFQKDSM-- 844

  Fly  1093 SQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFS 1157
                                                       .|:.|:|.|.::.::..|.:.|
Zfish   845 -------------------------------------------EVRTYINYLHLIDNQQTLFELS 866

  Fly  1158 LECEP 1162
            ...||
Zfish   867 HRLEP 871

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999
RasGEFN 279..400 CDD:214571 25/103 (24%)
PDZ_RapGEF2_RapGEF6-like 404..496 CDD:467237 16/91 (18%)
RA_PDZ-GEF1 759..841 CDD:340483 21/122 (17%)
RasGEF 871..1050 CDD:459872 75/179 (42%)
rapgef5bNP_001429535.1 None
Blue background indicates that the domain is not in the aligned region.

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